Buy Theo-24 Sr
Theo-24 Sr
Theo-24 Sr Properties
About Theo-24 Sr
Generic Theo-24 Sr (Theophylline) is an oral methyl-xanthine bronchodilator approved in Australia for the management of chronic obstructive pulmonary disease (COPD) and asthma when other controllers are insufficient. Each 200 mg tablet delivers the active ingredient theophylline, a compound that relaxes airway smooth muscle and improves diaphragmatic contractility. It is prescribed to adults who need sustained improvement in airflow and to those who experience exercise-induced bronchoconstriction. While the drug has a long history of use, clinicians monitor blood levels because the therapeutic window is narrow. Off-label, clinicians sometimes consider it for apnea of prematurity, but such use is strictly under specialist supervision.
What is Generic Theo-24 Sr (Theophylline)?
Generic Theo-24 Sr (Theophylline) belongs to the methyl-xanthine class of respiratory agents. It received approval from the Therapeutic Goods Administration (TGA) in the early 2000s and is listed as a prescription-only medicine (S4) in Australia. The tablet formulation provides a consistent 200 mg dose of theophylline, a compound first isolated from tea leaves and known for its bronchodilatory properties. As a generic product, it is bioequivalent to brand-name theophylline preparations, offering the same clinical effect at a lower cost.
How Theo-24 Sr Works
Theo-24 Sr exerts its effect by inhibiting phosphodiesterase-4 (PDE4), an enzyme that breaks down cyclic adenosine monophosphate (cAMP) in airway smooth-muscle cells. Elevated cAMP levels lead to relaxation of the bronchial muscles, widening the airways and reducing resistance to airflow. Additionally, theophylline antagonises adenosine receptors (A1 and A2), which diminishes bronchoconstriction and dampens inflammatory mediator release. After oral ingestion, the tablet is rapidly absorbed, reaching peak plasma concentrations within 1-2 hours. The drug’s elimination half-life averages 8-9 hours in healthy adults but can extend to 12 hours in smokers or those with hepatic impairment, reflecting metabolism primarily via CYP1A2. Because the therapeutic range (10-20 µg/mL) is narrow, clinicians often check serum levels after dose adjustments.
Why Theo-24 Sr Is Used for Respiratory Health Conditions
- Asthma uncontrolled by inhaled corticosteroids - By relaxing airway smooth muscle, Theo-24 Sr reduces the frequency of nocturnal symptoms and may decrease reliance on rescue inhalers. Guidelines list it as an add-on therapy for moderate-to-severe asthma when inhaler technique is optimal.
- Chronic obstructive pulmonary disease (COPD) - The drug improves forced expiratory volume (FEV₁) modestly and can lessen dynamic hyperinflation during exertion, offering functional benefits for patients with frequent exacerbations.
- Exercise-induced bronchoconstriction - A single dose taken 1 hour before activity can prevent the sharp fall in FEV₁ that some athletes experience, giving a pharmacologic option when inhaled pre-exercise regimens are impractical.
- Bronchiectasis with frequent sputum production - Theophylline’s mild anti-inflammatory effect may aid mucus clearance, not a first-line choice.
- Adjunct in sleep-disordered breathing (off-label) - Small trials suggest modest improvement in nocturnal ventilation, but it remains unapproved for this use in Australia.
In each scenario, the drug’s mechanism-raising intracellular cAMP and blocking adenosine-directly counters the pathophysiology of bronchoconstriction and airway hyper-responsiveness. Compared with long-acting β₂-agonists, theophylline provides a different pharmacologic pathway, which can be useful when tolerance to β-agonists develops.
Off-Label and Investigational Uses of Theo-24 Sr
Limited evidence from small randomized studies has explored theophylline in neonatal apnea and as an adjunct to opioid-induced respiratory depression. These investigations report modest reductions in apneic episodes but also highlight an increased risk of tachyarrhythmias in vulnerable infants. Because the TGA has not approved these indications, any off-label application should occur only under the direct supervision of a specialist in neonatal or respiratory medicine. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Theo-24 Sr Right for You?
Ideal candidates are adult patients with persistent asthma or COPD who remain symptomatic despite optimized inhaled therapy. The medication is especially useful for individuals who prefer oral dosing or who have contraindications to β₂-agonists. Caution is warranted in smokers, because tobacco induces CYP1A2, potentially lowering serum concentrations and necessitating higher doses. Pregnant or lactating women are generally advised against use unless the benefit clearly outweighs risk, as placental transfer occurs. Patients with severe hepatic impairment, uncontrolled cardiac arrhythmias, or a history of seizures should avoid the drug. As noted in the medication information, regular monitoring of serum theophylline levels helps maintain efficacy while minimizing toxicity.
Taking Theo-24 Sr Effectively
- Timing: Take the tablet with a full glass of water, preferably in the morning and early afternoon to avoid nighttime insomnia. Food does not markedly affect absorption, but a high-fat meal can delay peak levels by up to 30 minutes.
- Consistency: Maintain a regular schedule; missing a dose should be followed by taking it as soon as remembered unless it is within 4 hours of the next scheduled dose, in which case skip the missed one.
- Interactions: Caffeine, macrolide antibiotics (e.g., erythromycin), and fluoroquinolones (e.g., ciprofloxacin) inhibit CYP1A2 and can raise theophylline concentrations, increasing toxicity risk. Conversely, smoking, rifampicin, and carbamazepine accelerate metabolism, potentially reducing efficacy.
- Travel: When crossing time zones, adjust dosing to keep the interval between tablets close to 12 hours; avoid abrupt changes that could cause peaks or troughs.
- Hydration: Adequate fluid intake helps maintain renal clearance, especially in hot climates or during vigorous exercise.
Understanding Side Effects and How to Manage Them
Common adverse events-nausea, headache, insomnia, and tremor-arise from theophylline’s central nervous system stimulation and adenosine antagonism. Taking the medication with food may lessen gastrointestinal discomfort, while limiting caffeine intake can reduce jitteriness. Rare but serious effects such as cardiac arrhythmias, seizures, and severe hypotension usually signal serum levels above the therapeutic window. If palpitations, dizziness, or unexplained muscle twitching occur, obtain a blood draw for theophylline concentration and contact a prescriber promptly. For mild nausea, an antacid taken 30 minutes after the tablet often provides relief. Persistent insomnia may be mitigated by shifting the evening dose earlier or by using a short-acting formulation if available.
Buying Theo-24 Sr from Our Online Pharmacy
Why Choose Our Service?
Our online pharmacy streamlines access to prescription medicines for Australians living in remote areas or facing supply shortages. By partnering with licensed Australian wholesalers, we ensure that every shipment complies with TGA standards while offering competitive pricing for generic products like Theo-24 Sr.
Quality & Safety
Our pharmacy service works exclusively with suppliers that hold valid Australian Pharmacy Accreditation and meet WHO Good Manufacturing Practice guidelines. Each batch undergoes verification of batch numbers and expiry dates before dispatch, guaranteeing that you receive a product that matches the label specifications.
Pricing & Access
Generic Theo-24 Sr is typically 30-45 % less expensive than brand-name theophylline tablets. Through our platform, you can benefit from bulk-order discounts and a lifetime 10 % reduction on all reorders, making long-term therapy more affordable.
Discreet Delivery
We ship via express (approximately 7 days) or standard (up to 3 weeks) couriers, using nondescript packaging that protects privacy and product integrity. Tracking information is provided automatically, so you know exactly when your medication will arrive.
Frequently Asked Questions
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What blood level of theophylline is considered therapeutic? Serum concentrations between 10 µg/mL and 20 µg/mL achieve optimal bronchodilation while minimizing toxicity; levels above 25 µg/mL increase the risk of cardiac and neurologic side effects.
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Can I drink coffee while taking Theo-24 Sr? Caffeine is metabolised by the same CYP1A2 enzyme, so excessive intake may raise serum theophylline. Limiting coffee to one small cup per day is advisable.
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Why do smokers often need higher doses? Tobacco smoke induces CYP1A2 activity, accelerating theophylline clearance and shortening its half-life. Clinicians may increase the dose or monitor levels more frequently in regular smokers.
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Is it safe to use Theo-24 Sr with antihistamines? First-generation antihistamines (e.g., diphenhydramine) have sedative properties that can counteract theophylline-induced insomnia, but no direct pharmacokinetic interaction has been documented.
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How does theophylline differ from inhaled β₂-agonists? While β₂-agonists stimulate adrenergic receptors to relax airway muscle, theophylline raises intracellular cAMP by inhibiting phosphodiesterase and blocks adenosine receptors, offering a complementary pathway.
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Can I take Theo-24 Sr during a pregnancy? The drug crosses the placenta and has been associated with fetal tachycardia in animal studies. It is generally avoided unless the maternal benefit clearly outweighs potential fetal risk.
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What should I do if I miss a dose while traveling across time zones? Adjust the schedule so that doses remain approximately 12 hours apart; if the missed dose is within 4 hours of the next dose, skip it to avoid a high plasma peak.
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Is routine liver function testing required? Because theophylline is metabolised hepatically, baseline liver enzymes are useful before initiating therapy, especially in patients with known liver disease.
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Do I need to avoid any over-the-counter cold medicines? Decongestants containing pseudoephedrine can increase blood pressure and may exacerbate theophylline-related tachycardia. Always check labels and consult your pharmacist.
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How long does it take to feel relief after the first dose? Most adults notice improved breathing within 30 minutes, with peak effect around 1-2 hours as plasma concentrations rise.
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Will I need periodic blood tests forever? Monitoring is most critical after dose changes, when starting interacting medications, or if symptoms of toxicity appear. Stable patients often require testing only annually.
Glossary
- Phosphodiesterase-4 (PDE4)
- An enzyme that degrades cAMP; inhibition leads to increased airway smooth-muscle relaxation.
- CYP1A2
- A liver enzyme responsible for metabolising theophylline; activity can be induced or inhibited by other substances.
- Therapeutic Window
- The range of drug concentrations in blood that provides efficacy without unacceptable toxicity.
Disclaimer
The information provided about Theo-24 Sr is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Theo-24 Sr for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
