Buy Theo-24 Cr
Theo-24 Cr
Theo-24 Cr Properties
About Theo-24 Cr
Therapeutic options for chronic respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD) often include bronchodilators that relax airway smooth muscle. Generic Theo-24 Cr (Theophylline) is a methyl-xanthine derivative prescribed in Australia to improve airflow and reduce symptoms of airflow limitation. The active ingredient, theophylline, belongs to the class of phosphodiesterase inhibitors and has been used for decades as a maintenance therapy for adult patients who require additional bronchodilation beyond inhaled agents. While it is not a first-line choice in current guidelines, it remains a valuable option when inhaled medications are insufficient or unavailable.
What is Generic Theo-24 Cr (Theophylline)?
Generic Theo-24 Cr (Theophylline) is a prescription-only oral tablet containing 400 mg of theophylline anhydrous. The product is regulated by the Therapeutic Goods Administration (TGA) and listed on the Australian Medicines Handbook as a bronchodilator for the management of asthma and COPD in adults. As a generic formulation, it delivers the same active moiety as brand-named theophylline products, ensuring bioequivalence while offering a lower cost alternative for patients.
How Theo-24 Cr Works
Theo-24 Cr exerts its bronchodilatory effect through two complementary mechanisms:
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Phosphodiesterase-4 inhibition - By blocking the enzyme that degrades cyclic adenosine monophosphate (cAMP), theophylline raises intracellular cAMP levels in airway smooth-muscle cells. Elevated cAMP activates protein kinase A, which phosphorylates targets that reduce calcium-mediated contraction, leading to muscle relaxation.
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Adenosine-receptor antagonism - Theophylline competitively inhibits A1 and A2 receptors for adenosine, a molecule that normally promotes bronchoconstriction and inflammation. This antagonism diminishes reflex bronchospasm and dampens inflammatory cell activation.
Pharmacokinetic studies in Australian adult populations show that oral theophylline is absorbed within 30-60 minutes, reaching peak plasma concentrations in 2-3 hours. The drug is metabolised primarily by hepatic CYP1A2, and its elimination half-life ranges from 8 to 10 hours, which supports twice-daily dosing for stable plasma levels. Factors such as smoking, hepatic impairment, and concomitant use of CYP1A2 inhibitors (e.g., fluvoxamine) can markedly alter serum concentrations, necessitating therapeutic drug monitoring in certain patients.
Why Theo-24 Cr Is Used for Respiratory Conditions
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Asthma maintenance therapy
- Mechanistic fit: Bronchoconstriction driven by hyper-responsive airway smooth-muscle responds to cAMP-mediated relaxation.
- Guideline role: The Australian Asthma Handbook lists oral theophylline as a second-line add-on when inhaled corticosteroids and long-acting β-agonists are insufficient.
- Comparison: Compared with leukotriene modifiers, theophylline provides a more rapid bronchodilatory effect but carries a narrower therapeutic window.
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COPD exacerbation prevention
- Mechanistic fit: In COPD, chronic inflammation and smooth-muscle tone contribute to airflow limitation; phosphodiesterase inhibition mitigates both.
- Guideline role: The COPD Management Guideline recommends theophylline as an optional adjunct for patients with frequent exacerbations despite optimal inhaled therapy.
- Comparison: Oral theophylline is less potent than phosphodiesterase-4 selective agents (e.g., roflumilast) but may be preferred when cost is a primary concern.
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Bronchial hyper-responsiveness in smokers
- Mechanistic fit: Smoking induces CYP1A2 activity, lowering theophylline levels; dose adjustment restores therapeutic effect.
- Clinical benefit: Studies published in Chest demonstrate modest improvement in FEV₁ among smokers receiving theophylline as part of a combination regimen.
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Adjunct in occupational asthma
- Mechanistic fit: Theophylline’s anti-inflammatory properties attenuate responses to workplace irritants.
- Evidence: Small randomized trials show reduced symptom scores when theophylline is added to inhaled therapy for chemical-induced asthma.
Off-Label and Investigational Uses of Theo-24 Cr
Some clinicians have explored theophylline for conditions beyond its approved respiratory indications. Small pilot studies suggest potential benefit in adult obstructive sleep apnea by stabilising central respiratory drive, although the evidence remains limited and the Australian TGA has not approved such use. Another investigational avenue involves its anti-platelet activity, where in-vitro data indicate inhibition of platelet aggregation; however, clinical relevance has not been established.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Theo-24 Cr Right for You?
Theo-24 Cr suits adults who need an oral bronchodilator to complement inhaled therapies, particularly when adherence to inhalers is challenging or when cost constraints limit the use of newer agents. Ideal candidates include:
- Individuals with persistent asthma or COPD whose symptoms remain uncontrolled despite optimal inhaled regimens.
- Patients who have difficulty using inhaler devices due to dexterity issues.
- Those seeking a once- or twice-daily oral option.
Special populations require caution. In pregnancy, theophylline crosses the placenta and should be used only when the benefit outweighs potential risk. Elderly patients often have reduced hepatic clearance, increasing the risk of toxicity. Renal impairment has a modest effect, but dose reduction is advisable if creatinine clearance falls below 30 mL/min. Concomitant use of CYP1A2 inhibitors (e.g., cimetidine, fluoroquinolones) can raise serum levels, necessitating dose adjustments or alternative therapy.
Taking Theo-24 Cr Effectively
- Timing: Administer the tablet with a full glass of water, preferably in the morning and early evening to maintain steady plasma concentrations.
- Food interactions: High-fat meals can delay absorption; taking the drug on an empty stomach reduces variability.
- Missed dose: If a dose is forgotten within 4 hours, take it as soon as remembered; otherwise skip and resume the regular schedule-do not double-dose.
- Travel considerations: When crossing time zones, maintain the original dosing interval as closely as possible; temporary adjustments may be needed under medical guidance.
- Therapeutic monitoring: Serum theophylline levels should be checked after the first week of therapy and after any change in dose or interacting medication. Target concentrations typically range from 10-20 µg/mL for therapeutic effect while minimizing toxicity.
Understanding Side Effects and How to Manage Them
Theophylline’s narrow therapeutic index explains why side effects correlate with plasma concentration.
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Common, dose-related effects
- Nausea, vomiting, abdominal discomfort: Likely arise from direct gastric irritation and central nervous system stimulation. Taking the tablet with food (if tolerated) or using a gastro-protective agent can mitigate discomfort.
- Insomnia and tremor: Result from adenosine antagonism in the CNS. Administering the evening dose earlier (e.g., before 6 pm) reduces sleep disturbance.
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Cardiovascular concerns
- Palpitations, tachycardia: Elevated cAMP in cardiac tissue increases heart rate. If these symptoms emerge, an ECG and serum level assessment are warranted; dose reduction may be needed.
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Neurologic manifestations
- Headache, dizziness, seizures: High concentrations disrupt neuronal ion channels. Prompt measurement of serum theophylline is essential; severe toxicity (levels >30 µg/mL) requires emergency care.
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Serious, though rare, reactions
- Hypersensitivity rash, bronchospasm: May indicate an allergic mechanism unrelated to the drug’s bronchodilatory pathway. Discontinue immediately and seek medical attention.
Patients should report any new or worsening symptoms to their prescriber. Adjustments based on therapeutic drug monitoring often resolve mild adverse effects without compromising efficacy.
Buying Theo-24 Cr from Our Online Pharmacy
Why Choose Our Service?
Accessing Theo-24 Cr through traditional Australian pharmacies can be hindered by stock shortages or high out-of-pocket costs. Our online pharmacy offers a streamlined ordering process that delivers the medication directly to your door, preserving privacy and ensuring you receive a genuine, TGA-approved product.
Quality & Safety
We partner with licensed international wholesalers who meet stringent WHO Good Manufacturing Practice standards. Every batch is verified against the Australian Register of Therapeutic Goods before shipment, guaranteeing authenticity.
Pricing & Access
Because Theo-24 Cr is a generic formulation, it is priced significantly lower than brand-named equivalents. Our platform provides a lifetime 10 % discount on all reorders, making long-term maintenance therapy financially sustainable. If you prefer alternative oral methyl-xanthines, we list comparable options such as sustained-release theophylline tablets.
Discreet Delivery
Orders are packaged in unbranded, tamper-evident containers. Express shipping typically arrives within 7 days, while standard delivery takes up to three weeks, both with tracking to ensure timely receipt.
Frequently Asked Questions
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What is the optimal dosing schedule for Theo-24 Cr? The standard regimen for adults is 400 mg taken twice daily, spaced 12 hours apart, but dosing may be individualized based on serum theophylline levels and patient tolerance.
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Can I take Theo-24 Cr with other asthma inhalers? Yes, theophylline is intended as an add-on therapy and can be used alongside inhaled corticosteroids, long-acting β-agonists, or anticholinergics without known pharmacodynamic conflicts.
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How quickly will I feel relief after the first dose? Clinical data show onset of bronchodilation within 30-60 minutes, with maximal effect observed after 2-3 hours.
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Is smoking likely to reduce the effectiveness of Theo-24 Cr? Smoking induces hepatic CYP1A2, accelerating theophylline clearance and potentially lowering plasma concentrations; dose adjustments or smoking cessation are advised.
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Will Theo-24 Cr interact with caffeine? Both substances inhibit adenosine receptors; excessive caffeine can augment theophylline-related side effects such as insomnia or palpitations, so moderate intake is recommended.
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Do I need regular blood tests while on Theo-24 Cr? Therapeutic drug monitoring is recommended after initiating therapy, after dose changes, and when interacting drugs are started, to maintain serum levels within the therapeutic window.
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Can Theo-24 Cr be used during a COPD flare-up? It may be added temporarily to enhance bronchodilation during exacerbations, but patients should follow their physician’s acute-exacerbation plan, which often includes short-acting bronchodilators and steroids.
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Is Theo-24 Cr safe for people with heart disease? Caution is advised because theophylline can increase heart rate and precipitate arrhythmias; patients with uncontrolled cardiac conditions should discuss alternatives with their clinician.
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How does Theo-24 Cr compare to roflumilast? Roflumilast selectively inhibits phosphodiesterase-4 and offers anti-inflammatory benefits with a more favorable safety profile, but it is considerably more expensive. Theo-24 Cr provides broader bronchodilation at lower cost, albeit with a higher risk of systemic side effects.
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What should I do if I miss a dose for more than 8 hours? Skip the missed dose and resume your regular schedule; do not double-dose, as this raises the risk of toxicity.
Glossary
- Phosphodiesterase-4 (PDE-4)
- An enzyme that breaks down cyclic AMP; inhibition raises intracellular cAMP, leading to smooth-muscle relaxation and anti-inflammatory effects.
- Therapeutic drug monitoring (TDM)
- Measurement of drug concentrations in blood to ensure efficacy while avoiding toxicity, especially important for medications with narrow therapeutic windows.
- Adenosine receptor antagonism
- Blocking adenosine receptors reduces bronchoconstriction and inflammatory signaling, contributing to bronchodilation.
Disclaimer
The information presented about Theo-24 Cr is intended for general educational purposes and does not replace personalized medical advice. Any off-label application of the medication should be undertaken only under the direct supervision of a qualified healthcare professional. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy provides a convenient access route for individuals who may encounter limited availability through conventional pharmacies or who seek cost-effective generic alternatives. Always discuss any medication changes, including initiation, dose adjustments, or discontinuation, with your doctor.
