Buy Seroflo Inhaler
Seroflo Inhaler

$34.00
Category
Asthma & Breathing
Active Ingredients
Fluticasone Propionate, Salmeterol Xinafoate
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Prescription
Issued on site / Included
Availability
In Stock
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Seroflo Inhaler Properties

Primary Category
Respiratory Health
Pharmacological Class
Corticosteroid, Long‑Acting Beta‑Agonist
Minor Side Effects
Throat irritation , Cough , Hoarseness
Dosage Forms
Inhaler
Administration Route
Inhalation
Mechanism of Action
Reduces airway inflammation and relaxes airway muscles, making breathing easier during asthma or COPD attacks.
Prescription Status
Rx
Patient Summary
Helps prevent asthma attacks and control COPD symptoms by delivering medication directly to the lungs.
Onset Time
Within minutes
Duration
12 to 24 hours
Storage Instructions
Store at room temperature, protect from moisture
Age Restrictions
Not for use in children under 5
Pregnancy Use
Consult doctor before use during pregnancy

About Seroflo Inhaler

Generic Seroflo Inhaler (Fluticasone Propionate, Salmeterol Xinafoate) combines an inhaled corticosteroid with a long-acting β₂-agonist to control chronic airway inflammation and provide sustained bronchodilation. In Australia it is prescribed for moderate-to-severe asthma and for chronic obstructive pulmonary disease (COPD) when a single inhaler can simplify therapy. The two available strengths-25 µg/125 µg and 25 µg/250 µg per actuation-allow clinicians to tailor the anti-inflammatory and bronchodilatory components to each patient’s severity and response. While the product is approved for these indications, clinicians sometimes explore additional uses under specialist supervision.

Table of Contents

What is Generic Seroflo Inhaler (Fluticasone Propionate, Salmeterol Xinafoate)?

Generic Seroflo Inhaler (Fluticasone Propionate, Salmeterol Xinafoate) is a fixed-dose combination inhalation therapy classified as an inhaled corticosteroid/long-acting β₂-agonist (ICS/LABA). The Therapeutic Goods Administration (TGA) approved the formulation for routine asthma management in 2008 and later extended its indication to COPD. The device delivers a metered dose of both agents with each puff, ensuring consistent drug delivery to the lower respiratory tract. As a prescription-only medication in Australia, it requires a health-care professional’s endorsement before dispensing.

How Seroflo Inhaler Works

Fluticasone propionate is a potent glucocorticoid that binds to intracellular glucocorticoid receptors, altering gene transcription to suppress pro-inflammatory cytokines, reduce eosinophil migration, and stabilize airway epithelium. By dampening the inflammatory cascade, it prevents the swelling and mucus hypersecretion that narrow bronchioles.

Salmeterol xinafoate, a LABA, activates β₂-adrenergic receptors on bronchial smooth muscle. This triggers a rise in intracellular cyclic adenosine monophosphate (cAMP), leading to relaxation of the smooth muscle fibers and prolonged bronchodilation lasting up to 12 hours. The dual action provides both immediate symptom relief (via bronchodilation) and long-term control (via anti-inflammation).

Pharmacokinetically, fluticasone exhibits low systemic bioavailability (<1 %) after inhalation because of extensive first-pass metabolism, limiting systemic side-effects. Salmeterol reaches peak plasma concentrations within 30 minutes, yet its therapeutic effect persists due to strong receptor affinity and slow dissociation. Both agents are cleared primarily through hepatic metabolism (CYP3A4 for fluticasone, CYP2D6 for salmeterol), with renal excretion accounting for a minor fraction.

Why Seroflo Inhaler Is Used for Respiratory Health Conditions

  • Asthma, moderate-to-severe - The anti-inflammatory action of fluticasone reduces airway hyper-responsiveness, while salmeterol maintains open airways throughout the day, decreasing the need for rescue bronchodilators. Global and Australian asthma guidelines place an ICS/LABA combination as a step-3 or step-4 therapy when low-dose inhaled steroids alone are insufficient.
  • COPD, maintenance therapy - In COPD, chronic inflammation and airflow limitation coexist. The combination improves lung function (FEV₁) and lowers exacerbation rates, aligning with the National Asthma Council Australia’s recommendation for patients with frequent symptoms or a history of exacerbations.
  • Reduction of oral steroid dependence - By delivering potent local anti-inflammation, the inhaler often replaces systemic corticosteroids, reducing risks such as osteoporosis and glucose intolerance.
  • Convenient once-daily dosing - Both strengths are designed for twice-daily administration, simplifying adherence compared with separate inhalers for steroid and bronchodilator.
  • Cost-effectiveness in the long term - Although the upfront price exceeds that of a single-agent inhaler, the reduction in emergency visits and oral steroid courses yields overall health-system savings.

Off-Label and Investigational Uses of Seroflo Inhaler

Research in adult populations with bronchiectasis has examined the addition of an ICS/LABA combination to standard airway clearance regimens. A double-blind, placebo-controlled trial reported modest improvements in sputum volume and quality, though the study did not achieve statistical significance for primary endpoints. In pediatric pulmonology, limited case series have explored low-dose fluticasone/salmeterol for allergic rhinitis resistant to intranasal steroids, noting symptomatic relief but also raising concerns about growth suppression.

Off-label use should only be considered under the supervision of a qualified healthcare provider.

Is Seroflo Inhaler Right for You?

Patients who experience persistent wheeze, nighttime awakenings, or frequent rescue inhaler use despite low-dose inhaled steroids are typical candidates. Elderly individuals benefit from the once-daily regimen, yet clinicians must assess cardiac comorbidities because β₂-agonists can provoke tachycardia or arrhythmias in susceptible hearts. Pregnant or breastfeeding women should discuss potential risks; fluticasone’s low systemic absorption generally renders it safe, but salmeterol warrants caution. Those with severe hepatic impairment may require dose adjustments because metabolism is reduced. Always verify that no hypersensitivity to either component exists before initiating therapy.

Taking Seroflo Inhaler Effectively

  • Prime the device - Before first use, release three actuations into the air to ensure consistent spray.
  • Inhalation technique - Exhale fully, place the mouthpiece between lips, and inhale slowly and deeply while simultaneously activating the inhaler. Hold breath for about 10 seconds to maximize deposition in the lower airways.
  • Timing - Administer one puff twice daily, ideally 12 hours apart, such as morning and evening. Consistency improves bronchodilator coverage and anti-inflammatory control.
  • Missed dose - If a dose is forgotten, take it as soon as remembered unless the next scheduled dose is within two hours; then skip the missed dose to avoid double-dosing.
  • Travel considerations - Carry the inhaler in hand luggage, keep it upright, and avoid extreme temperatures. A small spacer can be useful for patients who struggle with coordination.

Understanding Side Effects and How to Manage Them

  • Oropharyngeal candidiasis - Fluticasone can suppress local immunity, fostering fungal overgrowth. Rinse the mouth with water and spit after each use; consider using a spacer to reduce oropharyngeal deposition.
  • Hoarseness or dysphonia - Local steroid exposure may irritate vocal cords. Voice rest and proper inhalation technique mitigate this effect.
  • Tremor, palpitations, or increased heart rate - Salmeterol’s β₂-agonist action can stimulate cardiac tissue. If symptoms persist, assess dosing schedule and evaluate for underlying arrhythmias.
  • Headache or musculoskeletal pain - Often transient; adequate hydration and balanced electrolytes help.
  • Serious reactions - Signs of hypersensitivity (rash, swelling, difficulty breathing) or adrenal suppression (severe fatigue, hypotension) warrant immediate medical attention.

Most side effects are mild and manageable with the strategies above, but promptly consulting a health-care professional is essential for any concerning symptom.

Buying Seroflo Inhaler from Our Online Pharmacy

Why Choose Our Service?

Access to prescription inhalers can be challenging in remote Australian regions. Our online pharmacy bridges that gap, delivering Seroflo Inhaler directly to your doorstep while maintaining full regulatory compliance.

Quality & Safety

We partner with licensed international pharmacies that adhere to TGA-mandated quality standards and WHO-good manufacturing practices, ensuring each inhaler meets potency and sterility criteria.

Pricing & Access

Because Seroflo Inhaler is available as a generic, the cost per device is substantially lower than brand-only options. Our platform offers a lifetime 10 % discount on all reorders, and bulk-purchase programmes further reduce out-of-pocket expenses.

Discreet Delivery

Orders are packaged in unmarked, protective envelopes. Express shipping typically arrives within 7 days, while standard delivery takes up to 3 weeks, both with tracking for peace of mind.

Frequently Asked Questions

  • How quickly will I notice symptom relief after the first inhalation? Bronchodilation from salmeterol begins within minutes, while the anti-inflammatory impact of fluticasone may take several days to manifest fully. Most patients report improved breathing within one to two weeks of consistent use.

  • Can I use Seroflo Inhaler alongside a rescue short-acting bronchodilator? Yes, a short-acting β₂-agonist (e.g., salbutamol) can be employed for acute symptom spikes. The combination does not cause harmful drug interactions when used as directed.

  • Is it safe to use this inhaler during an asthma attack? During an acute exacerbation, the inhaler’s long-acting component does not replace an immediate-action rescue inhaler. Continue using a rapid-onset bronchodilator for emergency relief.

  • What distinguishes the 25/125 µg from the 25/250 µg strength? Both contain the same corticosteroid dose; the latter provides a higher LABA dose, offering stronger bronchodilation for patients with more severe airflow limitation. Your clinician will select the appropriate strength based on lung function tests.

  • Do I need to clean the inhaler regularly? Minimal maintenance is required. Rinse the mouthpiece with warm water weekly and allow it to air-dry. Do not submerge the device or use harsh detergents, as this can damage the valve mechanism.

  • Can I switch from a separate ICS and LABA inhaler to Seroflo Inhaler? Transitioning to a fixed-dose combination simplifies dosing and improves adherence, provided the total daily doses of each component remain equivalent. A physician will verify dose equivalence before conversion.

  • Is there any risk of tolerance developing to the LABA component? Tolerance to β₂-agonists is uncommon when used as part of an ICS/LABA regimen, because the anti-inflammatory steroid mitigates receptor down-regulation. Nonetheless, regular review of symptom control is advisable.

  • What should I do if I accidentally inhale too many puffs? An overdose may cause pronounced tachycardia, tremor, or hypokalemia. Seek medical attention promptly; symptomatic treatment may involve beta-blockers or electrolyte correction.

  • Are there any dietary restrictions while using Seroflo Inhaler? No specific food interactions exist. However, maintaining a balanced diet supports overall lung health and may reduce systemic inflammation.

  • Can I use this inhaler if I have a known allergy to lactose? Some inhaler formulations contain lactose as a carrier. If you have a severe lactose intolerance or allergy, discuss alternative delivery systems with your prescriber.

Glossary

Glucocorticoid receptor
A cytoplasmic protein that, upon binding a corticosteroid, translocates to the nucleus and modulates gene expression to suppress inflammation.
β₂-adrenergic receptor
A G-protein-coupled receptor on airway smooth muscle that, when activated, raises intracellular cAMP, leading to muscle relaxation and bronchodilation.
cAMP (cyclic adenosine monophosphate)
A secondary messenger that mediates the bronchodilatory effects of β₂-agonists by promoting smooth-muscle relaxation.
First-pass metabolism
The rapid hepatic processing of a drug after absorption, which reduces the amount reaching systemic circulation.
Spacer
An attachment for inhalers that creates a reservoir of aerosol, allowing larger particles to deposit in the lungs and reducing oropharyngeal deposition.

Disclaimer

The information presented about Seroflo Inhaler is intended for general educational purposes and does not substitute professional medical advice. Any off-label application must occur under the direct supervision of a qualified healthcare provider. Readers are responsible for assessing the relevance of this content to their personal health circumstances. Our online pharmacy provides a convenient access pathway for individuals who may face limited availability through traditional dispensing channels or who seek affordable generic options. Always consult a qualified clinician before initiating, altering, or discontinuing any medication.

External Resources about Seroflo Inhaler

Information Prepared By

Sarah Jones
Patient Advocate & Health Writer
Tosin (Olalekan) Olaluwoye, MD, PhD
Postdoctoral Fellow (Men's Health Equity) & Medical Doctor