Buy Fluticasone + Salmeterol
Fluticasone + Salmeterol
Fluticasone + Salmeterol Properties
About Fluticasone + Salmeterol
Fluticasone + Salmeterol is a fixed-dose inhaler that combines an inhaled corticosteroid with a long-acting β2-agonist. It is prescribed for the chronic management of asthma and chronic obstructive pulmonary disease (COPD) in adults. The inhaler delivers either 250 µg fluticasone and 50 µg salmeterol or 500 µg fluticasone and 50 µg salmeterol per actuation, providing anti-inflammatory protection alongside sustained bronchodilation. In Australia the product is listed on the Pharmaceutical Benefits Scheme (PBS) and is a Schedule 4 prescription medication.
What is Generic Fluticasone + Salmeterol?
Generic Fluticasone + Salmeterol belongs to the combination inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) class. It received TGA registration for maintenance therapy of asthma and COPD after clinical trials demonstrated improved lung function and reduced exacerbations compared with either component alone. The product is marketed in metered-dose inhaler (MDI) form, with two strength options: 250/50 µg and 500/50 µg. It is intended for twice-daily use and is not suitable as a rescue inhaler.
How Fluticasone + Salmeterol Works
Fluticasone propionate, the corticosteroid component, binds to glucocorticoid receptors in airway epithelial cells. This interaction modulates gene transcription, suppressing the synthesis of pro-inflammatory cytokines (IL-4, IL-5, TNF-α) and reducing eosinophilic infiltration. The result is decreased airway edema, mucus hypersecretion, and hyper-responsiveness.
Salmeterol xinafoate, the long-acting β2-agonist, selectively stimulates β2-adrenergic receptors on airway smooth-muscle cells. Activation increases intracellular cyclic AMP, which relaxes smooth muscle and keeps the bronchi open for up to 12 hours. Because salmeterol’s binding is prolonged, it maintains bronchodilation while fluticasone addresses the underlying inflammation.
Pharmacokinetically, fluticasone has a high first-pass hepatic metabolism, limiting systemic exposure; its pulmonary bioavailability is roughly 20 %. Salmeterol is also extensively metabolised by CYP3A4, with an oral bioavailability of <5 %. The inhaled route delivers therapeutic concentrations directly to the lungs, achieving rapid onset (within minutes for bronchodilation) and sustained anti-inflammatory action over several hours.
Why Fluticasone + Salmeterol is Used for Respiratory Conditions
- Asthma maintenance - The dual action reduces chronic inflammation and prevents bronchoconstriction, leading to fewer nighttime symptoms and a lower need for oral corticosteroids. Guidelines such as GINA place high-dose ICS/LABA combinations as step 4-5 therapy for patients uncontrolled on medium-dose inhaled steroids alone.
- COPD management - Salmeterol improves expiratory flow, while fluticasone curtails the inflammatory component common in COPD exacerbations. The GOLD strategy recommends a LABA/ICS for patients with a history of exacerbations and an eosinophilic phenotype (blood eosinophils ≥300 µL⁻¹).
- Reduced exacerbations - Large-scale RCTs (e.g., the TORCH and FLAME studies) showed that the combination lowered the annual rate of severe exacerbations compared with monotherapy, translating into fewer hospital admissions.
- Convenient dosing - Twice-daily inhalation aligns with patients' routine (morning and evening), enhancing adherence relative to more frequent dosing schedules.
- Dose flexibility - The 250/50 µg option suits patients requiring lower corticosteroid exposure, while the 500/50 µg strength benefits those needing stronger anti-inflammatory control without increasing the LABA dose.
- Safety profile - By delivering the drugs directly to the lungs, systemic side effects such as adrenal suppression or tachycardia are minimized compared with oral agents.
Off-Label and Investigational Uses of Fluticasone + Salmeterol
Evidence from small pilot studies suggests potential benefit in bronchiectasis patients with chronic bacterial colonisation, where inflammation and airway obstruction coexist. A phase II trial reported modest improvements in sputum volume and quality-of-life scores, but the combination remains unapproved for this indication in Australia. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Fluticasone + Salmeterol Right for You?
The inhaler is most appropriate for adults whose asthma or COPD is not adequately controlled with a single inhaled corticosteroid or a short-acting bronchodilator. Ideal candidates:
- Require maintenance therapy and have experienced two or more exacerbations in the past year.
- Demonstrate an eosinophilic phenotype (blood eosinophils ≥300 µL⁻¹) in COPD, which predicts a better response to the steroid component.
- Are able to use a metered-dose inhaler correctly; correct technique ensures optimal drug deposition and reduces oropharyngeal side effects.
Patients with uncontrolled hypertension, recent myocardial infarction, or known hypersensitivity to either ingredient should discuss alternatives with their clinician. Pregnant or breastfeeding women can use the inhaler when the therapeutic benefit outweighs potential risk, but this decision must be individualized.
Taking Fluticasone + Salmeterol Effectively
- Timing - Inhale one puff in the morning and one in the evening, preferably after meals to minimise local irritation.
- Inhaler technique - Shake the canister, exhale fully, place the mouthpiece between teeth, seal lips, and press the canister while breathing in slowly and deeply. Hold breath for 10 seconds before exhaling.
- Rinse after use - Rinse the mouth with water and spit out to reduce the risk of oropharyngeal candidiasis, a known side effect of inhaled corticosteroids.
- Missed dose - If a dose is missed, take it as soon as remembered unless it is within 2 hours of the next scheduled dose; then skip the missed dose and continue the regular schedule. Do not double-dose.
- Travel - Keep the inhaler in its original container, protect it from extreme temperatures, and carry a spare canister for long trips.
Understanding Side Effects and How to Manage Them
- Oral thrush (candidiasis) - Caused by local immunosuppression from fluticasone. Prevent by rinsing mouth after each use; treat with topical antifungal lozenges if symptoms appear.
- Hoarseness or dysphonia - Irritation of vocal cords; use a spacer device and practice proper inhalation technique to reduce deposition in the throat.
- Headache or mild tremor - Linked to systemic β2-agonist activity; usually transient and diminishes with continued use. If persistent, discuss dose adjustment.
- Increased heart rate or palpitations - Result from salmeterol’s systemic absorption; rare at prescribed inhaled doses but warrants medical review if symptomatic.
- Paradoxical bronchospasm - Very uncommon; if wheezing worsens immediately after inhalation, seek urgent care.
Serious adverse events such as adrenal suppression, severe arrhythmias, or allergic reactions are rare but require immediate medical attention.
Buying Fluticasone + Salmeterol from Our Online Pharmacy
Why Choose Our Service?
Accessing maintenance inhalers can be challenging, especially in remote areas. Our online pharmacy streamlines the process, offering a discreet, secure portal where you can obtain your prescribed inhaler without unnecessary delays.
Quality & Safety
We partner with licensed international pharmacies that adhere to Australian Therapeutic Goods Administration (TGA) standards. All stock is sourced from GMP-certified manufacturers, and each batch undergoes rigorous quality checks before shipment.
Pricing & Access
Our platform negotiates bulk purchasing rates, allowing us to pass on savings of up to 30 % compared with retail pharmacy prices. Generic Fluticasone + Salmeterol is eligible for PBS rebates where applicable, further reducing out-of-pocket costs. A lifetime 10 % discount applies to all repeat orders placed through our service.
Discreet Delivery
Orders are packaged in neutral, tamper-evident boxes. Express shipping typically arrives within 7 days, while standard delivery takes about 3 weeks. Tracking information is provided for every shipment, ensuring you know exactly when your medication will arrive.
Frequently Asked Questions
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How quickly will I feel relief after using Fluticasone + Salmeterol? The bronchodilator component begins working within minutes, smoothing the airways. Full anti-inflammatory benefits develop over several days of consistent use.
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Can I use a spacer with this inhaler? Yes. A spacer can improve lung deposition and reduce oropharyngeal deposition, which may lessen local side effects such as thrush.
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Is there a risk of dependence on the inhaler? The medication is not habit-forming. However, it is intended for maintenance therapy, not rescue relief. Over-reliance on a rescue inhaler (e.g., salbutamol) while neglecting maintenance dosing can lead to poorer control.
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What should I do if I forget to rinse my mouth after each dose? If you notice symptoms of oral candidiasis (white patches, soreness), rinse vigorously now and maintain the habit moving forward. An over-the-counter antifungal can be used while you arrange a review with your doctor.
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How does this combination differ from using separate inhalers for steroids and LABA? Combining the drugs in a single device ensures synchronized delivery, improves adherence, and eliminates the need for coordinating two separate inhalers. The pharmacokinetic profiles remain the same as when the agents are administered together but with greater convenience.
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Are there any foods or beverages I should avoid? No specific dietary restrictions exist. However, avoid consuming large amounts of caffeine if you are sensitive to β2-agonist-induced tremor.
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Can I switch between the 250/50 µg and 500/50 µg strengths without a new prescription? Dose adjustments should be made under medical supervision to ensure optimal control and to monitor for side effects.
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Is this inhaler suitable for elderly patients? Yes, provided they can master the inhaler technique or use a spacer. Age-related decreases in lung elasticity may affect drug deposition, so periodic review of technique is advisable.
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What monitoring is required while on this therapy? Routine assessment includes lung function testing (spirometry) every 3-6 months, review of symptom control, and checking for side effects such as oral thrush or hoarseness.
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Can I use Fluticasone + Salmeterol during a pregnancy flare-up? Inhaled corticosteroids are generally considered low-risk in pregnancy, and the benefits of maintaining asthma control often outweigh potential risks. Discuss any dosage changes with your obstetrician.
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How does the drug interact with other common medications? Systemic β2-agonists may enhance the effects of sympathomimetic drugs (e.g., decongestants) and may increase heart rate when combined with certain anti-arrhythmics. Fluticasone is metabolised by CYP3A4; strong inhibitors (ketoconazole, clarithromycin) could modestly raise systemic exposure, though clinical significance is low with inhaled dosing.
Glossary
- Glucocorticoid receptor
- A cellular protein that, when bound by corticosteroids, regulates gene transcription to suppress inflammation.
- β2-adrenergic receptor
- A receptor on airway smooth-muscle cells; activation causes muscle relaxation and bronchodilation.
- GOLD strategy
- Global Initiative for Chronic Obstructive Lung Disease guidelines that classify COPD severity and recommend treatments.
- Spirometry
- A pulmonary function test measuring airflow obstruction and reversibility, essential for monitoring inhaled therapy effectiveness.
- PBS
- Pharmaceutical Benefits Scheme, the Australian government program that subsidises prescription medicines for eligible patients.
Disclaimer
The information provided about Fluticasone + Salmeterol is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy offers access to Fluticasone + Salmeterol for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
