Buy Eldepryl
Eldepryl
Eldepryl Properties
About Eldepryl
Generic Eldepryl (Selegiline) is an oral medication approved in Australia to treat Parkinson’s disease, primarily as an adjunct to levodopa therapy. The active ingredient, selegiline, belongs to the class of monoamine oxidase-B (MAO-B) inhibitors, which help preserve dopamine levels in the brain and thereby reduce motor fluctuations. While its main indication is Parkinson’s disease, clinicians sometimes consider it for depressive disorders under strict supervision. Eldepryl is supplied as 5 mg and 10 mg tablets and requires a prescription from a qualified health professional.
What is Generic Eldepryl (Selegiline)?
Generic Eldepryl (Selegiline) is a Schedule 4 prescription drug marketed in Australia as a selective irreversible inhibitor of the enzyme monoamine oxidase-B. First approved by the Therapeutic Goods Administration (TGA) in the early 1990s, it is listed on the Pharmaceutical Benefits Scheme (PBS) for use in patients whose Parkinsonian symptoms are not adequately controlled with levodopa alone. The product is manufactured by several international firms, but it is sold under the brand-type name Eldepryl to distinguish it from other selegiline formulations. As a generic, it delivers the same clinical efficacy and safety profile as any selegiline reference product.
How Eldepryl Works
Selegiline targets monoamine oxidase-B, an enzyme located in neuronal mitochondria that degrades dopamine, phenylethylamine, and trace amines. By binding covalently to the flavin adenine dinucleotide (FAD) cofactor within MAO-B, the drug produces irreversible inhibition. This effect persists until new enzyme molecules are synthesized, typically over 24-48 hours. As a result, synaptic dopamine concentrations rise, smoothing the motor fluctuations that characterize Parkinson’s disease.
After oral ingestion, the tablet dissolves in the gastric tract, and selegiline is rapidly absorbed. Peak plasma levels appear within 1-2 hours. The drug undergoes extensive first-pass metabolism, producing L-amphetamine and L-methamphetamine metabolites at low concentrations; these metabolites contribute modestly to central stimulation but are far less potent than their dextro counterparts. The average elimination half-life of selegiline itself is about 10 hours, while its metabolites have half-lives of 12-14 hours. Hepatic cytochrome P450 enzymes (CYP2B6, CYP2C19, CYP2D6) mediate clearance, and approximately 30 % of the dose is excreted unchanged in urine.
Why Eldepryl Is Used for Parkinson’s Disease Treatment
- Enhances dopaminergic tone - By preventing dopamine breakdown, selegiline prolongs the effect of levodopa, allowing patients to achieve smoother motor control with lower levodopa doses.
- Reduces “off” periods - Clinical trials demonstrate a 20-30 % reduction in daily “off” time when selegiline is added to standard therapy.
- Delays levodopa-induced dyskinesia - The drug’s dopamine-sparing action may postpone the onset of involuntary movements linked to long-term levodopa exposure.
- First-line adjunct - Australian Parkinson’s disease guidelines list selegiline as a recommended add-on for patients experiencing wearing-off phenomena.
- Cost-effective - Generic formulations such as Eldepryl provide the same therapeutic benefit as branded MAO-B inhibitors at a lower price point, easing the financial burden on patients.
Off-Label and Investigational Uses of Eldepryl
Evidence from small, double-blind studies suggests that selegiline may have antidepressant properties, particularly in treatment-resistant major depressive disorder. These trials report modest improvements in mood scores at a 10 mg daily dose, likely mediated by increased phenylethylamine and trace amine activity. However, the TGA has not approved Eldepryl for depression, and the safety profile at higher doses requires careful monitoring for hypertension. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Eldepryl Right for You?
Eldepryl suits adults with Parkinson’s disease whose motor symptoms persist despite optimal levodopa dosing. It is especially helpful for those who experience “on-off” fluctuations or early dyskinesia. Patients with well-controlled hypertension, stable liver function, and no history of severe psychiatric illness are typical candidates. The drug is not recommended for individuals taking certain serotonergic agents because of a theoretical risk of serotonin syndrome. Pregnant or breastfeeding women should avoid selegiline, as safety data are limited. Elderly patients may require dose adjustments if renal or hepatic impairment is present, though most studies indicate the standard 5 mg daily dose remains well-tolerated.
Taking Eldepryl Effectively
- Timing - Take the tablet in the morning with a glass of water; food does not significantly affect absorption, but a light breakfast can reduce gastrointestinal upset.
- Avoid tyramine-rich foods - At the 5 mg dose, dietary tyramine restrictions are minimal, but higher doses (10 mg) may provoke hypertensive reactions if large amounts of aged cheese, cured meats, or soy sauce are consumed.
- Missed dose - If you forget a dose, take it as soon as you remember unless it is close to the next scheduled dose; then skip the missed tablet and continue the regular schedule.
- Travel - Carry the medication in its original packaging with a copy of the prescription. The tablet’s stability is maintained at room temperature for up to two years, so no special storage is needed while abroad.
- Alcohol - Moderate alcohol consumption is permissible, but excessive intake can amplify dizziness and orthostatic hypotension.
Understanding Side Effects and How to Manage Them
Common adverse effects arise from increased central catecholamine activity and include nausea, headache, dizziness, and insomnia. Nausea often resolves within the first week; taking the tablet with food can mitigate this symptom. Headaches may be alleviated by staying hydrated and avoiding abrupt posture changes. Insomnia can be reduced by limiting caffeine after midday and ensuring the dose is taken early in the day. Orthostatic hypotension, reported in up to 10 % of patients, is managed by rising slowly from seated positions and monitoring blood pressure regularly.
Serious reactions are rare but demand urgent attention. Hypertensive crisis, characterized by sudden blood pressure spikes (>180/110 mmHg), can occur if large tyramine loads are ingested while on the 10 mg dose. Immediate medical evaluation is essential. Rare cases of psychosis or severe depression have been linked to selegiline’s amphetamine-like metabolites; patients should report mood changes promptly. If any side effect becomes intolerable or persists beyond two weeks, contact a healthcare professional for possible dose adjustment or drug discontinuation.
Buying Eldepryl from Our Online Pharmacy
Why Choose Our Service?
Access to Parkinson’s disease medicines can be challenging in remote Australian communities. Our online pharmacy bridges that gap, offering a discreet, regulated channel to obtain Eldepryl without compromising quality. By leveraging bulk purchasing agreements, we keep prices lower than many brick-and-mortar outlets, making long-term therapy more affordable.
Quality & Safety
We partner with licensed international pharmacies that adhere to Australian TGA standards and WHO Good Manufacturing Practices. Every batch of Eldepryl undergoes rigorous third-party testing for potency, purity, and contamination before shipment, ensuring you receive a product that matches the reference formulation.
Pricing & Access
The cost of a 30-day supply of 5 mg tablets is typically 45 % less than the branded alternative listed on the PBS. For patients who need the 10 mg strength, we provide a bundled discount that reduces the per-tablet price by 30 %. Repeat customers enjoy a lifetime 10 % discount on all reorders, helping maintain consistent therapy without financial strain.
Discreet Delivery
Orders are processed within 24 hours and dispatched via a secure courier network. Express shipping delivers the medication to most Australian postcodes in approximately 7 days, while standard delivery reaches remote areas within three weeks. All packages are sealed in unmarked, tamper-evident envelopes to protect privacy.
Frequently Asked Questions
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What should I do if I accidentally consume a large amount of tyramine while on Eldepryl? At the 5 mg dose, occasional tyramine intake rarely triggers a hypertensive response, but with higher doses the risk increases. If you experience sudden headache, palpitations, or a rise in blood pressure, seek medical attention immediately.
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Can Eldepryl be taken together with antidepressants? Combining selegiline with selective serotonin reuptake inhibitors (SSRIs) or other serotonergic agents may raise the chance of serotonin syndrome. Your clinician can assess risk and adjust therapy accordingly.
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Is it safe to use Eldepryl if I have mild liver disease? Selegiline is metabolised by the liver, so dosing may need adjustment in moderate to severe hepatic impairment. Mild liver dysfunction usually does not require a change, but routine liver function monitoring is advised.
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How long does it take to notice improvement after starting Eldepryl? Most patients report reduced “off” periods within 2-4 weeks, though full stabilization of motor symptoms can take up to three months as the enzyme inhibition becomes complete.
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Will Eldepryl interfere with my sleep patterns? Because selegiline can increase catecholamine levels, some individuals experience insomnia, especially if the dose is taken later in the day. Adjusting the dosing time to the morning often resolves sleep disturbances.
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Are there any dietary restrictions besides tyramine? Apart from limiting high-tyramine foods at the 10 mg dose, there are no specific restrictions. Maintaining a balanced diet and adequate hydration supports overall treatment effectiveness.
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Can I switch from another MAO-B inhibitor to Eldepryl without a washout period? A short washout of 14 days is generally recommended when transitioning between irreversible MAO-B inhibitors to avoid additive inhibition. Your prescriber will devise a safe switch plan.
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Is it possible to obtain a 10 mg tablet if I only need a higher dose occasionally? The 10 mg strength is prescribed when clinicians aim for a higher pharmacologic effect, such as in off-label depression treatment. It is not intended for intermittent “as-needed” use; consistent daily dosing is required for efficacy.
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What monitoring is required while on Eldepryl? Routine assessments include blood pressure checks, liver function tests every six months, and periodic evaluation of motor symptoms. Any new neurological or cardiovascular symptoms should be reported promptly.
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Can I travel internationally with Eldepryl? Yes, provided you carry a copy of the prescription and the original pharmacy label. Some countries may require a letter from your doctor confirming medical necessity; check local regulations before departure.
Glossary
- MAO-B
- Monoamine oxidase-B, an enzyme that degrades dopamine and other neurotransmitters in the brain.
- Irreversible inhibition
- A type of enzyme blockade where the inhibitor forms a permanent covalent bond, requiring new enzyme synthesis for activity to resume.
- Bioavailability
- The proportion of an orally administered drug that reaches systemic circulation in an active form.
- Half-life
- The time required for the plasma concentration of a drug to reduce by 50 %.
- Amphetamine metabolites
- Minor breakdown products of selegiline (L-amphetamine and L-methamphetamine) that possess mild stimulant properties.
Disclaimer
The information provided about Eldepryl is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy offers a regulated access solution for individuals who may encounter limited availability, insurance restrictions, or cost barriers with traditional pharmacies. Always consult your doctor before starting, changing, or discontinuing any medication.
