Buy Azilsartan
Azilsartan
Azilsartan Properties
About Azilsartan
Generic Azilsartan is an oral antihypertensive pill approved in Australia for the management of high blood pressure. As a member of the angiotensin II receptor blocker (ARB) class, it works by interrupting the renin-angiotensin-aldosterone system, helping to relax blood vessels and lower systemic pressure. The medication is typically supplied in 40 mg tablets, with combination strengths such as 40 mg/12.5 mg when paired with a thiazide diuretic. While its primary indication is hypertension, clinicians may consider it for certain cardiovascular risk-reduction strategies when standard therapies are insufficient.
What is Generic Azilsartan?
Generic Azilsartan is a synthetic compound that selectively blocks the angiotensin II type 1 (AT₁) receptor. It received TGA approval in 2015 and is listed on the Australian Pharmaceutical Benefits Scheme (PBS) for patients with hypertension who have not achieved target blood pressure with other ARBs or ACE inhibitors. The drug is marketed as a solid oral tablet, available in monotherapy doses of 40 mg and in fixed-dose combinations that incorporate a low-dose thiazide diuretic (12.5 mg). Being a generic product, it delivers the same therapeutic effect as branded versions such as Edarbi, while offering a more affordable option for Australians.
How Azilsartan Works
Azilsartan belongs to the ARB family, which antagonizes the AT₁ receptor located on vascular smooth-muscle cells, adrenal cortex, and renal tubular epithelium. By preventing angiotensin II from binding, the drug blocks a cascade that ordinarily triggers vasoconstriction, sodium retention, and sympathetic activation. The result is three-fold:
- Vasodilation: Smooth-muscle relaxation reduces peripheral resistance.
- Natriuresis: Inhibition of aldosterone release lowers sodium and water reabsorption, decreasing plasma volume.
- Neuro-horm dampening: Reduced sympathetic outflow limits heart rate and contractility.
Pharmacokinetically, azilsartan is rapidly absorbed after oral administration, reaching peak plasma concentrations within 1-2 hours. It is extensively metabolised to an active carboxylate metabolite, which contributes to its prolonged antihypertensive effect lasting up to 24 hours. Elimination occurs primarily via the feces (≈55 %) and urine (≈30 %), with a terminal half-life of about 11 hours, supporting once-daily dosing.
Why Azilsartan is Used for Cardiovascular Health Conditions
- Essential hypertension: By lowering systemic vascular resistance, azilsartan achieves clinically meaningful reductions in systolic and diastolic pressure, often exceeding those of older ARBs. Guidelines from the National Heart Foundation place it as a viable first-line option for patients requiring potent blood-pressure control.
- Resistant hypertension: When added to a thiazide diuretic (12.5 mg), the combination exploits complementary mechanisms-vascular relaxation and volume depletion-addressing cases unresponsive to monotherapy.
- Renoprotection in diabetic patients: Although not PBS-listed for this purpose, studies show ARBs reduce albuminuria and slow progression of diabetic nephropathy, a benefit attributable to reduced intraglomerular pressure.
- Heart-failure risk reduction: By attenuating afterload and neuro-hormonal activation, azilsartan may lower the incidence of heart-failure events in high-risk hypertensive cohorts, aligning with evidence supporting ARB class effects.
These uses reflect azilsartan’s ability to target the underlying pathophysiology of elevated blood pressure and its downstream cardiovascular complications.
Off-Label and Investigational Uses of Azilsartan
Limited data suggest azilsartan may improve outcomes in chronic kidney disease and in patients with left-ventricular hypertrophy, but such applications have not been approved by the TGA. Small pilot trials have reported modest reductions in proteinuria and regression of ventricular wall thickness. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Azilsartan Right for You?
Azilsartan is most appropriate for adults with primary hypertension who require robust blood-pressure lowering or who have not tolerated ACE inhibitors due to cough. It is suitable for elderly patients because its once-daily schedule simplifies adherence, and the drug’s pharmacokinetic profile does not demand dose adjustment in mild to moderate renal impairment. Pregnant or breastfeeding women should avoid azilsartan, as ARBs are contraindicated in the second and third trimesters. Patients with severe hepatic dysfunction may need close monitoring, although the medication is primarily excreted via the bile. As noted in the medication information, individuals with known hypersensitivity to azilsartan or other ARBs should not use this product.
Taking Azilsartan Effectively
Take azilsartan tablet whole, preferably at the same time each morning, with or without food. Consistency enhances steady plasma levels and maximises blood-pressure control. If a dose is missed and the next scheduled dose is >12 hours away, take the missed tablet immediately; otherwise, skip it and resume the regular schedule. Avoid excessive salt intake, as high dietary sodium can blunt the antihypertensive effect. When using the 40 mg/12.5 mg combination, maintain adequate hydration to support the diuretic component. Travel across time zones? Adjust the dosing time gradually to preserve a 24-hour interval, and keep a short supply in your hand luggage to prevent interruptions.
Understanding Side Effects and How to Manage Them
Common adverse events-headache, dizziness, and mild fatigue-often stem from the initial vasodilatory response and usually resolve within the first two weeks. To mitigate dizziness, rise slowly from sitting or lying positions and consider monitoring blood pressure at home during the titration phase. Elevated potassium (hyperkalaemia) can occur because ARBs reduce aldosterone-mediated potassium excretion; routine serum potassium checks are advisable, especially in patients taking potassium-sparing diuretics or supplements. Rare but serious reactions include angio-edema and acute renal impairment; these are linked to an idiosyncratic hypersensitivity or abrupt hemodynamic changes. Seek immediate medical attention if you develop swelling of the face, tongue, or difficulty breathing, or if urine output markedly declines.
Buying Azilsartan from Our Online Pharmacy
Why Choose Our Service?
Our online pharmacy bridges the gap between prescription requirements and convenient access, ensuring Australians can obtain azilsartan without unnecessary delays.
Quality & Safety
We partner with licensed international pharmacies that operate under strict regulatory frameworks, guaranteeing that every tablet meets WHO-approved Good Manufacturing Practice standards.
Pricing & Access
Because azilsartan is available as a generic, our platform offers it at a fraction of the branded price. You also benefit from a lifetime 10 % discount on all reorders, making long-term therapy more affordable.
Discreet Delivery
Orders are dispatched in neutral packaging, with express shipping arriving in approximately 7 days and standard shipping within 3 weeks. Tracking information is provided for every shipment.
Frequently Asked Questions
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How quickly will I see a drop in my blood pressure? Most patients notice a modest reduction within one week, with the full antihypertensive effect typically achieved after 2-4 weeks of consistent dosing.
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Can I take azilsartan with other blood-pressure medicines? Azilsartan is often combined with calcium-channel blockers or thiazide diuretics to enhance control; however, dosage adjustments may be necessary to avoid excessive hypotension.
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Is there a risk of cough with azilsartan? Unlike ACE inhibitors, azilsartan does not increase bradykinin levels, so the characteristic dry cough is uncommon.
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What monitoring is required while on azilsartan? Baseline and periodic checks of blood pressure, serum potassium, and renal function are recommended, especially in patients with chronic kidney disease.
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Can I use azilsartan if I have heart failure? Although not specifically approved for heart failure in Australia, the drug’s ARB class effects can be beneficial; any use should be guided by a cardiologist.
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Will alcohol interfere with azilsartan? Moderate alcohol consumption does not directly affect the drug’s metabolism, but excessive intake may elevate blood-pressure variability and counteract treatment goals.
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Does azilsartan interact with over-the-counter supplements? Potassium-rich supplements, licorice extracts, and non-steroidal anti-inflammatory drugs can increase the risk of hyperkalaemia or renal impairment; discuss any supplement use with your prescriber.
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Is a dose change ever necessary? Dose escalation from 40 mg to the combination tablet (40 mg/12.5 mg) is common when target pressure is not reached after 2 weeks of monotherapy.
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Can I store azilsartan in the bathroom cabinet? Keep the tablets in a cool, dry place away from direct sunlight; the bathroom environment may introduce humidity that degrades potency.
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What should I do if I forget a dose? If the missed dose is less than 12 hours away from the next scheduled dose, skip it and continue as planned; otherwise, take it as soon as you remember.
GlossAngiotensin II receptor blocker (ARB)
: A class of drugs that inhibit the AT₁ receptor, preventing angiotensin II-induced vasoconstriction and aldosterone release.
- Natriuresis
- The excretion of sodium in the urine, which helps lower blood volume and blood pressure.
- Hyperkalaemia
- An elevated serum potassium level that can cause cardiac arrhythmias; a known risk with ARBs.
- Pharmacokinetics
- The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body.
- in-angiotensin-aldosterone system (RAAS)
- A hormonal cascade that regulates blood pressure, fluid balance, and electrolyte homeostasis.
Disclaimer
The information provided about azilsartan is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to azilsartan for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
