Buy Cyproterone acetate and ethinylestradiol
Cyproterone acetate and ethinylestradiol
Cyproterone acetate and ethinylestradiol Properties
About Cyproterone acetate and ethinylestradiol
Generic Cyproterone acetate and ethinylestradiol is a fixed-dose oral combination that pairs a potent antiandrogenic progestogen with a synthetic estrogen. In Australia it is listed under the therapeutic class of combined oral contraceptives and is also approved for managing androgen-dependent skin conditions such as severe acne and hirsutism. The formulation delivers 2 mg of cyproterone acetate and .035 mg of ethinylestradiol per tablet, providing both contraceptive protection and hormonal regulation for patients with hormonal disorders.
What is Generic Cyproterone acetate and ethinylestradiol?
Generic Cyproterone acetate and ethinylestradiol belongs to the combined oral contraceptive (COC) group and is classified as a prescription-only medicine by the Therapeutic Goods Administration (TGA). The product contains cyproterone acetate, a first-generation progestogen with strong antiandrogen activity, and ethinylestradiol, a synthetic estrogen that stabilises the endometrial cycle. In many markets the same fixed-dose combination is marketed under the brand name Diane-35; Australian prescribers may also encounter it as a generic supplied by various manufacturers. As a generic, it must demonstrate bio-equivalence to the reference listed drug, ensuring comparable efficacy and safety at a lower cost.
How Cyproterone acetate and ethinylestradiol Works
Cyproterone acetate binds to androgen receptors, blocking the action of dihydrotestosterone (DHT) and testosterone in target tissues such as skin and sebaceous glands. This antagonism reduces sebum production, slowing the formation of acne lesions and diminishing unwanted hair growth. Simultaneously, cyproterone exerts progestogenic activity that suppresses the hypothalamic-pituitary-gonadal axis, decreasing luteinising hormone (LH) and follicle-stimulating hormone (FSH) release, which curtails ovarian androgen output.
Ethinylestradiol, the estrogen component, provides negative feedback to the pituitary, further lowering LH and FSH levels. It also stabilises the endometrium, preventing breakthrough bleeding that can accompany pure antiandrogen therapy. Pharmacokinetic data show rapid absorption after oral intake, with peak plasma concentrations reached within 1-2 hours. Cyproterone acetate undergoes hepatic metabolism via CYP3A4, while ethinylestradiol is largely metabolised by CYP2C9 and conjugated to glucuronides. The combined half-life supports once-daily dosing, and steady-state concentrations are achieved after about 7 days of regular intake.
Why Cyproterone acetate and ethinylestradiol is Used for Hormonal Disorders, Acne, and Hair Growth Conditions
- Severe Acne Vulgaris - By blocking androgen receptors in sebaceous glands, the combination reduces sebum output, addressing a primary driver of inflammatory acne. Guidelines from the Australian Medicines Handbook place it as a second-line oral therapy after topical agents and oral antibiotics have failed.
- Hirsutism (excessive facial or body hair) - Antiandrogenic activity diminishes hair-follicle stimulation, leading to slower hair growth and, over several months, visible reduction in hair density. It is recommended when mechanical or laser hair removal are insufficient.
- Polycystic Ovary Syndrome (PCOS) with hyperandrogenism - The drug normalises androgen levels while providing reliable contraception, making it a dual-purpose option for women seeking both cycle regulation and symptom control.
- Endometriosis-related pain - The estrogen component stabilises the endometrium, and the progestogenic effect induces decidualisation, which can alleviate dysmenorrhoea in selected patients.
- Contraception - The ethinylestradiol component ensures ovulation suppression, offering pregnancy protection alongside the antiandrogenic benefits.
Compared with other COCs that contain levonorgestrel or drospirenone, cyproterone acetate delivers markedly stronger antiandrogen effects, making it the preferred choice when androgen blockade is a therapeutic goal.
Off-Label and Investigational Uses of Cyproterone acetate and ethinylestradiol
Clinical case series and small open-label trials have explored this combination for gender-affirming hormone therapy in transgender women, showing reductions in facial hair growth and improvements in skin texture. However, the TGA has not approved it for this indication, and robust randomized controlled trials are lacking.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Cyproterone acetate and ethinylestradiol Right for You?
Patients who need reliable contraception and present with clinically significant androgen excess are typical candidates. The medication is generally well-tolerated in women aged 18-45 who are non-smokers or light smokers. Those with a history of thrombo-embolic disease, uncontrolled hypertension, or liver dysfunction are advised against its use, as noted in the product information. Pregnant or breastfeeding women should not start therapy, and caution is required in individuals with migraine with aura. Elderly patients are rarely prescribed this combination because the risk-benefit balance shifts toward higher thrombotic risk.
Taking Cyproterone acetate and ethinylestradiol Effectively
- Timing: Take one tablet at the same time each day, preferably with food to minimise gastrointestinal upset.
- Food & Drink Interactions: Grapefruit juice can inhibit CYP3A4 and modestly increase cyproterone levels; avoid large amounts.
- Missed Dose: If a dose is missed within 12 hours, take it immediately; otherwise skip the missed tablet and continue the regular schedule. Do not double-dose.
- Travel: Carry a short-term supply in hand luggage; the tablets are stable at room temperature for up to 24 months when stored in the original blister.
- Lifestyle Integration: Combine the regimen with a low-glycemic diet and regular skin-care routine to maximise acne improvement.
Understanding Side Effects and How to Manage Them
The most common adverse events-weight gain, breast tenderness, and mild nausea- stem from the estrogen component’s fluid-retaining properties and hepatic metabolism. To reduce bloating, limit sodium intake and stay hydrated. Breast tenderness often subsides after the first menstrual cycle; wearing a supportive bra can provide comfort.
Serious but less frequent risks include venous thrombo-embolism (VTE) and hepatic dysfunction. VTE is linked to estrogen-induced changes in clotting factors; patients should seek immediate medical attention for unexplained leg swelling, chest pain, or shortness of breath. Liver enzyme monitoring is advisable for individuals with pre-existing hepatic disease.
If severe mood changes or visual disturbances occur, discontinue the medication and contact a healthcare professional promptly, as these may signal rare hormonal imbalances.
Buying Cyproterone acetate and ethinylestradiol from Our Online Pharmacy
Why Choose Our Service?
Our online pharmacy bridges the gap for Australian patients who encounter limited stock or high co-payment costs at local pharmacies. By ordering through our platform, you gain discreet, fast access to a quality-assured generic product at a price often 30 % lower than brand-name equivalents.
Quality & Safety
We partner with licensed international pharmacies that comply with TGA-registered Good Manufacturing Practice (GMP) standards. Every batch undergoes third-party testing for potency, purity, and packaging integrity before dispatch.
Pricing & Access
A 28-day pack of 2 mg/.035 mg tablets is priced competitively, with a Lifetime 10 % discount on all reorders. For patients seeking alternatives, we also stock other combined oral contraceptives such as levonorgestrel/ethinylestradiol tablets.
Discreet Delivery
Orders are shipped in unmarked packaging; express delivery arrives in approximately 7 days, while standard delivery takes up to 3 weeks. All shipments are tracked, ensuring you know exactly when your medication will arrive.
Frequently Asked Questions
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Is Cyproterone acetate and ethinylestradiol suitable for men with acne? The formulation is approved only for women; its hormonal effects can cause feminisation in men, so it is not recommended.
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Can I use this medication while taking antibiotics? Certain antibiotics, such as rifampicin, can lower ethinylestradiol concentrations, potentially reducing contraceptive efficacy. Discuss any concurrent medication with your prescriber.
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Will the antiandrogen effect appear immediately? Clinical improvement in acne or hirsutism typically begins within 4-6 weeks, with maximal benefit observed after 3-6 months of continuous therapy.
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How does this combination compare to drospirenone-based pills for acne? Drospirenone offers mild anti-androgenic activity, but cyproterone acetate provides a stronger blockade, making it more effective for severe androgen-driven skin disease.
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Is it safe to take this pill if I smoke socially? Smoking increases VTE risk, especially in women over 35. Light, occasional smoking (<5 cigarettes/day) is generally considered acceptable, but cessation is advised.
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What should I do if I experience breakthrough bleeding? Missed or delayed tablets are the most common cause. Take the missed dose as soon as possible and continue the schedule; if bleeding persists beyond two cycles, consult a healthcare professional.
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Can I use this medication to delay menstruation? Skipping the active pills in a pack can postpone withdrawal bleeding, but the antiandrogen benefits are best maintained with uninterrupted daily dosing.
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Does the medication interact with herbal supplements like St John’s wort? St John’s wort induces CYP3A4 and may reduce cyproterone levels, potentially diminishing efficacy. It is advisable to avoid concurrent use.
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Is there a risk of weight gain specific to the antiandrogen component? Weight changes are largely attributable to the estrogen component’s fluid retention; cyproterone acetate itself does not directly promote adipose tissue accumulation.
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Will this pill affect my cholesterol profile? Ethinylestradiol can raise triglycerides modestly, while cyproterone may increase HDL. Routine lipid monitoring is recommended for patients with an existing dyslipidaemia.
Glossary
- Antiandrogen
- A substance that blocks the actions of male hormones (androgens) at their receptor sites, reducing effects such as sebum production and hair growth.
- CYP3A4
- A liver enzyme responsible for metabolising many drugs; inhibition or induction can alter drug plasma levels.
- Negative feedback
- A hormonal control mechanism where increased hormone levels signal the hypothalamus or pituitary gland to reduce further hormone release.
Disclaimer
The information provided about Cyproterone acetate and ethinylestradiol is intended for general educational purposes and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy offers access to this medication for individuals who may face limited availability through traditional channels or who seek more affordable generic options. Always consult your doctor before starting, changing, or discontinuing any medication.
