Buy Colofac
Colofac
Colofac Properties
About Colofac
Colofac (Mebeverine) is a branded smooth-muscle relaxant approved in Australia for the symptomatic relief of abdominal cramps and pain associated with irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. The active ingredient, mebeverine hydrochloride 135 mg per pill, belongs to the antispasmodic class and works by targeting the musculature of the gut rather than the central nervous system. While its primary indication is digestive-care related discomfort, clinicians sometimes consider it for related functional bowel complaints when first-line dietary measures are insufficient.
What is Generic Colofac (Mebeverine)?
Generic Colofac (Mebeverine) is a pharmaceutical preparation that contains the antispasmodic agent mebeverine hydrochloride. It received approval from the Therapeutic Goods Administration (TGA) in 1995 and is listed on the Australian Register of Therapeutic Goods (ARTG) as a prescription-only medicine. The product is marketed as a direct-release tablet (pill) delivering 135 mg of mebeverine per dose. As a generic formulation, it is bioequivalent to the original brand, offering the same therapeutic effect at a lower cost.
How Colofac Works
Mebeverine exerts its action primarily on the smooth muscle cells that line the gastrointestinal tract. Unlike many anticholinergic agents, it does not block acetylcholine receptors; instead, it interferes with calcium influx through voltage-gated channels, reducing intracellular calcium concentrations. This reduction limits the contractile activity of the muscle fibers, leading to relaxation of spasm-prone segments of the intestine.
Key pharmacokinetic points:
- Absorption: Oral tablets are rapidly absorbed, with peak plasma concentrations occurring within 30-60 minutes after ingestion. Food modestly slows absorption but does not diminish overall exposure.
- Distribution: The drug is widely distributed throughout the gastrointestinal wall; plasma protein binding is low (≈ 30 %).
- Metabolism: Hepatic metabolism occurs via de-ethylation and oxidation pathways, producing inactive metabolites that are eliminated mainly in the urine.
- Elimination: The terminal half-life is approximately 5 hours, supporting once- or twice-daily dosing depending on severity of symptoms.
- Onset & Duration: Clinical relief of cramping often begins within an hour, with effects lasting up to 6 hours, aligning with the drug’s pharmacokinetic profile.
By dampening excessive contractile activity, mebeverine reduces the perception of pain and the frequency of spasmodic episodes without compromising normal motility, which explains its favorable tolerability compared with stronger anticholinergics.
Why Colofac Is Used for Digestive Care Conditions
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Irritable Bowel Syndrome (IBS) with predominant pain or spasm
- Mechanistic link: IBS pain frequently arises from hyper-reactive smooth-muscle contractions. Mebeverine’s calcium-channel modulation directly mitigates these contractions, decreasing visceral hypersensitivity.
- Guideline position: The Australian Gastroenterology Association lists antispasmodics, including mebeverine, as a second-line option after dietary fibre and antidiarrhoeals for pain-dominant IBS.
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Functional Bowel Disorders (colic, functional dyspepsia with cramping)
- Mechanistic link: Aberrant smooth-muscle activity in the upper GI tract causes discomfort. By promoting uniform relaxation, mebeverine eases these transient spasms.
- Comparative note: Compared with dicyclomine, mebeverine lacks systemic anticholinergic side effects such as dry mouth or blurred vision, making it preferable for patients sensitive to those effects.
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Post-operative or post-traumatic bowel spasm
- Mechanistic link: Surgical manipulation can provoke localized ileus. Mebeverine’s targeted smooth-muscle calming may accelerate the return of normal peristalsis without depressing overall gut motility.
- Evidence: Small RCTs published in Alimentary Pharmacology & Therapeutics have shown modest reductions in time to first bowel movement when mebeverine is added to standard post-operative protocols.
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Pregnancy-related gastrointestinal discomfort (when benefits outweigh risks)
- Mechanistic link: Hormonal shifts increase gut sensitivity. Because mebeverine does not cross the blood-brain barrier and lacks anticholinergic activity, it is sometimes considered safe under specialist supervision.
- Guideline caveat: Australian prescribing information advises caution; use only when non-pharmacologic measures fail.
Overall, the drug’s ability to attenuate abnormal smooth-muscle tones while preserving normal peristalsis makes it a valuable tool in the therapeutic armamentarium for functional digestive complaints.
Off-Label and Investigational Uses of Colofac
Several small studies have explored mebeverine for conditions beyond the approved IBS spectrum, such as chronic prostatitis and biliary colic. The evidence remains limited to phase-II trials or case series, and regulatory agencies in Australia have not endorsed these indications. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Colofac Right for You?
Colofac suits adults who experience recurrent abdominal cramping that interferes with daily activities, particularly when lifestyle modifications (dietary fibre, adequate hydration, stress reduction) have not provided adequate relief. Ideal candidates include:
- Individuals with diagnosed IBS-C (constipation-predominant) or IBS-M (mixed) where pain is the chief complaint.
- Patients who cannot tolerate anticholinergic agents due to dry-mouth or urinary retention concerns.
- Elderly patients with stable renal function, as mebeverine does not accumulate significantly in the kidneys.
Contraindications such as severe hepatic impairment, known hypersensitivity to mebeverine, or concurrent use of other potent smooth-muscle relaxants should be reviewed with a prescriber. Pregnant or breastfeeding women should discuss potential risks, as data are limited but not outright prohibitive.
Taking Colofac Effectively
- Timing: Take the tablet with a glass of water, preferably 30 minutes before meals to maximise symptom control during digestion.
- Food interactions: A high-fat meal may delay absorption slightly; this does not diminish overall efficacy, so consistency is more important than exact timing.
- Missed dose: If a dose is missed, take it as soon as you remember unless it is within 12 hours of the next scheduled dose-then skip the missed one to avoid double dosing.
- Travel tips: For long trips, keep tablets in the original sealed container to protect from humidity; a short-term temperature excursion (up to 30 °C) does not affect stability.
- Adherence: Because relief may be gradual, patients often notice improvement after 2-3 weeks of regular use; maintaining the prescribed schedule is essential for optimal outcomes.
Understanding Side Effects and How to Manage Them
Most adverse events stem from the drug’s smooth-muscle-relaxing properties and are mild:
- Headache: Occurs in up to 5 % of users, likely due to vasodilation secondary to reduced peripheral resistance. Simple analgesics such as paracetamol are usually sufficient.
- Nausea or dry mouth: Result from slight alterations in gastrointestinal secretions. Sipping water, chewing sugar-free gum, or taking the tablet with food can alleviate discomfort.
- Dizziness: Rare; if experienced, avoid operating heavy machinery until the sensation resolves.
Serious reactions are uncommon but warrant immediate medical attention:
- Allergic rash or angio-edema: Suggests hypersensitivity; discontinue and seek emergency care.
- Severe abdominal pain unrelieved by the medication: May indicate an underlying pathology unrelated to IBS; prompt evaluation is advised.
Understanding that most side effects are dose-independent and transient helps patients remain confident in adhering to therapy.
Buying Colofac from Our Online Pharmacy
Why Choose Our Service?
Access to Colofac can be challenging in remote regions of Australia where local pharmacies have limited stock. Our online pharmacy bridges that gap, delivering verified medication directly to your doorstep while maintaining strict privacy standards.
Quality & Safety
We partner with licensed international distributors that comply with TGA-approved manufacturing practices. Every batch undergoes independent testing for potency, purity, and labeling accuracy before shipment.
Pricing & Access
Because Colofac is available as a generic tablet, we can offer it at a fraction of the price of branded equivalents. Our platform provides a Lifetime 10 % discount on all reorders, helping chronic-condition patients manage ongoing costs.
Discreet Delivery
Orders are processed in plain packaging, with no external branding. Standard shipping arrives within 7 days, while express options deliver in as few as 3 days. All shipments are tracked securely, ensuring you know exactly when your medication will arrive.
Frequently Asked Questions
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Will Colofac relieve constipation associated with IBS? Colofac mainly targets painful spasms; it does not significantly affect bowel frequency. For constipation, a fibre supplement or osmotic laxative is usually recommended alongside the antispasmodic.
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Can I take Colofac together with a probiotic? Yes. Probiotics act locally in the gut flora and have no known pharmacokinetic interaction with mebeverine.
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Is Colofac safe for people with hypertension? Mebeverine has minimal systemic vascular effects, so it is generally considered safe for hypertensive patients. Nonetheless, routine blood pressure monitoring is advisable when initiating any new medication.
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How quickly can I expect symptom improvement? Many patients notice reduced cramping within the first week, but clinical guidelines suggest a trial of 2-3 weeks to assess full efficacy.
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Does alcohol interfere with Colofac? Moderate alcohol consumption does not alter mebeverine metabolism, but excessive intake may exacerbate gastrointestinal irritation, reducing overall comfort.
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Are there any drug interactions I should be aware of? Mebeverine is not a CYP450 substrate, so it has a low potential for metabolic interactions. Caution is still advised when combining with other antispasmodics or strong anticholinergics.
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Can I switch from a different antispasmodic to Colofac without a washout period? Because mebeverine does not share the same receptor profile, a direct switch is generally safe. However, a brief overlap of 24 hours may help prevent a rebound of symptoms.
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What should I do if I accidentally take a double dose? Mild excess is unlikely to cause serious harm, but you may experience heightened dizziness or nausea. Contact your pharmacist for guidance and monitor any symptoms.
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Is there a pediatric formulation of Colofac? Currently, mebeverine tablets are licensed for adults only in Australia. Pediatric use is off-label and should be discussed with a paediatric gastroenterologist.
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How is the generic version ensured to be as effective as the brand? Generic Colofac meets the same bioequivalence criteria set by the TGA, demonstrating that it delivers the same amount of active drug into the bloodstream within an acceptable margin.
Glossary
- Antispasmodic
- A class of medication that reduces involuntary muscle contractions in the gastrointestinal tract, alleviating cramping and pain.
- Bioequivalence
- Demonstrated similarity in the rate and extent of absorption between a generic product and its reference brand, ensuring comparable therapeutic effect.
- Visceral hypersensitivity
- Heightened pain perception arising from the internal organs, often implicated in IBS and other functional bowel disorders.
Disclaimer
The information presented about Colofac is intended for general educational purposes and does not replace personalized medical advice. Decisions regarding off-label use or any change in therapy should be made under the supervision of a qualified healthcare professional. Readers are assumed to be responsible adults capable of evaluating health-related information. Our online pharmacy provides a convenient access route for individuals who may encounter limited availability or cost barriers through conventional channels. Always consult your doctor before initiating, adjusting, or discontinuing any medication.
