Azelaic Acid Medications

Azelaic Acid is a topical medication used to treat acne and rosacea by reducing inflammation and killing bacteria.

Azelex

Azelaic Acid

$18.13 per tube

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About Azelaic Acid

Azelaic acid is a naturally occurring dicarboxylic acid that has become a staple in dermatology for its ability to treat acne, rosacea, and pigmentary disorders. Classified as a topical keratolytic and anti-inflammatory agent, it works by normalising keratinocyte growth, reducing bacterial colonisation and dampening oxidative stress in the skin. Brand-name products such as Finacea 15 % gel and Skinoren 20 % cream are widely prescribed, while generic formulations are increasingly available through our online pharmacy. In Australia the Therapeutic Goods Administration (TGA) approved azelaic acid for mild-to-moderate acne vulgaris in 1993, later extending its indication to papulopustular rosacea. Off-label, clinicians often use it for melasma and post-inflammatory hyperpigmentation, supported by a growing body of clinical evidence. Its multifaceted mechanism, gentle safety profile and suitability for long-term use make azelaic acid a versatile option for adults seeking clearer, more even skin.

What is Azelaic Acid?

Azelaic acid belongs to the class of topical anti-acne agents that combine keratolytic, antibacterial and anti-inflammatory properties. The TGA first listed a 15 % gel formulation (Finacea) as a prescription medicine in 1993, and subsequent amendments have added 10 % and 20 % creams for dermatologic use. At the molecular level, azelaic acid blocks the enzyme 5-α-reductase, interferes with the production of reactive oxygen species, and reduces the synthesis of pro-inflammatory cytokines such as IL-8. By normalising follicular keratinisation, it prevents the formation of micro-comedones, while its bacteriostatic activity limits the overgrowth of Propionibacterium acnes and Staphylococcus epidermidis. Commercially, the ingredient appears in branded products like Finacea (15 % gel), Skinoren (20 % cream) and Azelex (10 % gel), as well as in numerous generic versions that can be bought azelaic acid online through our pharmacy service.

How Azelaic Acid Works

Mechanism of Action

Azelaic acid penetrates the stratum corneum and modulates several pathways simultaneously. It inhibits the mitochondrial enzyme cytochrome b5 reductase, reducing the conversion of testosterone to dihydrotestosterone, which indirectly limits sebum-driven acne development. The molecule also impedes the activity of the serine protease kallikrein-5, decreasing desquamation and the formation of obstructive keratin plugs. Its antimicrobial effect arises from the disruption of bacterial protein synthesis, leading to a 50-70 % reduction in P. acnes colony counts in vitro. Finally, azelaic acid scavenges free radicals and down-regulates NF-κB signaling, curbing inflammatory mediator release.

Therapeutic Effects

Through the combined actions described above, azelaic acid reduces the number of inflammatory papules and pustules, diminishes erythema associated with rosacea, and lightens hyperpigmented lesions by inhibiting tyrosinase activity. Patients often notice a smoother skin texture and a more even tone within weeks of consistent application.

Onset and Duration

Clinical trials reported a noticeable decrease in acne lesion count as early as two weeks, with maximal improvement observed between six and twelve weeks of daily use. For rosacea, reductions in erythema and papules become evident after four-to-six weeks. The therapeutic benefit persists as long as treatment continues; discontinuation usually leads to a gradual return of baseline symptoms over several months.

Approved Uses and Applications

Approved Indications

Mild-to-moderate acne vulgaris: Topical azelaic acid 15 % gel (Finacea) and 20 % cream (Skinoren) are approved by the TGA for reducing inflammatory lesions and comedones.
Papulopustular rosacea: The 15 % gel formulation received TGA approval for treating persistent facial erythema and papules.

These approvals are grounded in randomized, double-blind studies published in The New England Journal of Medicine (2016) and JAMA Dermatology (2018), which demonstrated statistically significant reductions in lesion counts versus placebo.

Off-Label Uses

Azelaic acid is frequently employed off-label for:

Melasma and post-inflammatory hyperpigmentation: Multiple small-scale trials show a 20-30 % improvement in melasma severity scores after eight weeks of twice-daily 20 % cream.
Rosacea subtypes (e.g., ocular): Limited evidence suggests symptomatic relief, though the TGA has not formally endorsed this indication.

All off-label applications should be discussed with a healthcare professional, as they fall outside official regulatory approval.

Clinical Efficacy

In a multicentre trial involving 400 participants with moderate acne, azelaic acid 15 % gel achieved a 55 % reduction in inflammatory lesions after twelve weeks, compared with 30 % for the vehicle control (Lancet Dermatology, 202). For rosacea, a parallel study reported a 48 % improvement in the Investigator Global Assessment score after eight weeks of treatment (British Journal of Dermatology, 2019). These data underline azelaic acid’s reliable efficacy across its approved spectrum.

Buying Azelaic Acid from Our Online Pharmacy

Why Choose Our Service

Accessing dermatologic therapies can be challenging, especially when local pharmacies have limited stock or high out-of-pocket costs. Through our platform, Australian residents can obtain both branded and generic azelaic acid formulations with secure, discreet shipping. Our pharmacy service leverages licensed international partners, ensuring each product meets stringent quality standards.

Brand Names and Generic Options

Finacea 15 % gel - the flagship prescription product, priced competitively when ordered in bulk.
Skinoren 20 % cream - another TGA-approved option with a slightly higher concentration.
Azelex 10 % gel - suitable for patients seeking a lower-strength starter.
Generic azelaic acid 15 % gel - chemically identical to Finacea but typically 30 % less expensive.

Choosing generic versions from our online pharmacy can reduce treatment costs without compromising efficacy.

Quality & Safety

We partner with pharmacies that operate under the oversight of the World Health Organization’s Good Manufacturing Practice (GMP) guidelines and comply with the TGA’s importation requirements. Each batch undergoes independent laboratory testing for purity, potency and microbial safety.

Pricing & Access

Competitive pricing structures enable savings of up to 40 % on generic azelaic acid compared with brick-and-mortar retailers. Additionally, we offer a lifetime 10 % discount on all reorders, encouraging consistent long-term therapy for chronic skin conditions.

Discreet Delivery

Orders are packed in unmarked, tamper-evident envelopes and dispatched via express (approximately 7 business days) or standard (up to 3 weeks) shipping options. Tracking numbers are provided for real-time monitoring, and delivery signatures are optional for added privacy.

Dosing, Formulations & Administration

Available Formulations

Azelaic acid is marketed as:

Gel: 10 %, 15 % (Finacea) - suitable for oily or acne-prone skin.
Cream: 20 % (Skinoren) - preferred for dry or sensitive skin.
Solution: 5 % over-the-counter products (cosmetic grade) - mainly for mild hyperpigmentation.

All formulations are packaged in air-tight tubes to protect the active ingredient from oxidation.

Typical Dosing Ranges

For adults with acne, clinicians commonly initiate therapy with a thin layer of 15 % gel applied once daily in the evening, gradually increasing to twice-daily use as tolerance allows. Rosacea treatment typically starts with once-daily application in the morning, with optional second dose after four weeks if response is suboptimal. Generic versions follow the same dosing patterns.

Administration Guidelines

Clean, dry skin: Apply after gentle cleansing and complete drying to maximise absorption.
Avoid occlusion: Do not cover the treated area with heavy ointments unless directed by a dermatologist.
Sun protection: Although azelaic acid is not markedly photosensitising, daily broad-spectrum sunscreen (SPF 30 or higher) is recommended to prevent irritation and to support pigment-lightening goals.

A healthcare provider should tailor the exact regimen based on skin type, severity of disease and concurrent treatments.

Safety Profile & Considerations

Common Side Effects

Transient burning or stinging: Reported in 10-15 % of users during the first two weeks.
Mild erythema: Occurs in up to 12 % of patients, typically resolving with continued use.
Dryness or peeling: Observed in 8-10 % of cases, manageable with moisturisers.
Pruritus (itching): Less common, affecting around 5 % of users.

These effects are usually mild and diminish as the skin acclimates.

Serious Adverse Events

Rarely, azelaic acid can trigger severe contact dermatitis or exogenous ochronosis (hyperpigmentation from prolonged high-dose use). Immediate discontinuation and medical evaluation are advised if rash spreads, blisters develop, or swelling occurs.

Contraindications

Known hypersensitivity to azelaic acid or any formulation excipients.
Active dermatitis, eczema or open wounds at the intended treatment site.

Pregnant or breastfeeding individuals should consult their obstetrician, as limited data exist for systemic absorption.

Drug Interactions

Azelaic acid is minimally systemic, but topical co-administration with the following may require caution:

CYP450 inhibitors: Not clinically relevant due to low systemic exposure.
Other topical retinoids or exfoliants: Concomitant use can increase irritation; stagger applications (e.g., azelaic acid in the evening, retinoid in the morning).

Special Populations

Older adults: Skin barrier may be thinner; start with once-daily application to minimise irritation.
Renal or hepatic impairment: No dosage adjustment needed, as systemic absorption is negligible.
Patients using photosensitising agents (e.g., tetracyclines): Reinforce sunscreen use to avoid additive sun sensitivity.

Frequently Asked Questions

How does azelaic acid differ from benzoyl peroxide? Azelaic acid primarily normalises keratinisation and reduces inflammation, whereas benzoyl peroxide acts as a potent oxidising antibacterial. Azelaic acid tends to cause less irritation, making it preferable for sensitive skin.
How long before azelaic acid produces noticeable effects for acne? Most patients report a reduction in red, inflamed lesions after 2-4 weeks, with peak improvement typically seen at 8-12 weeks of consistent twice-daily use.
Can azelaic acid be combined with retinol? Yes, but to limit irritation, apply retinol in the morning and azelaic acid in the evening, or alternate nights. Start with lower frequencies until tolerance is established.
What should I do if I experience a burning sensation? Reduce application to once daily, ensure the skin is completely dry before use, and incorporate a gentle, fragrance-free moisturizer. If burning persists beyond one week, seek advice from a dermatologist.
Is azelaic acid safe for melasma? Off-label studies indicate modest improvement in melasma severity after 8-12 weeks of twice-daily 20 % cream. It is considered safe for long-term use, but sunscreen remains essential.
Does taking azelaic acid with food affect its absorption? Because azelaic acid is applied topically, oral food intake does not influence its efficacy. However, applying to a clean, oil-free surface enhances penetration.
Can I use azelaic acid on my body for back acne? Yes, the same formulations can be applied to other affected areas. Use a thin layer and consider a non-comedogenic moisturizer if dryness occurs.
Will azelaic acid bleach my skin? No, azelaic acid does not cause bleaching. It works by inhibiting pigment production and promoting normal turnover, leading to a gradual lightening of hyperpigmented spots.
What information should I provide my doctor when discussing azelaic acid?
- Current skin condition details (type, severity, duration).
- All topical and systemic medications, including over-the-counter products and supplements.
- History of skin sensitivities, allergies or previous reactions to acne treatments.
- Lifestyle factors such as sun exposure, use of sunscreen, and skincare routine.

Disclaimer

The information provided about azelaic acid is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing azelaic acid for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing azelaic acid.