Ticlopidine Medications

Ticlopidine is an antiplatelet medication used to prevent blood clots and reduce the risk of thrombotic stroke in at-risk patients by inhibiting platelet aggregation.


Buy Ticlopidine Medications


Ticlid

Ticlopidine

$2.97 per pill

250mg

Ticlopidine

Ticlopidine

$2.97 per pill

250mg


Ticlopidine Platelet Inhibitor Details

Ticlopidine is an antiplatelet medication classified as a thienopyridine. By irreversibly blocking the P2Y12 ADP receptor on platelets, it reduces platelet aggregation and helps prevent clot formation. The drug is primarily indicated for secondary prevention of ischemic stroke and transient ischemic attack (TIA) in adults who have already experienced such events. Branded as Ticlid and available in generic form, ticlopidine can be purchased through our online pharmacy, offering a discreet alternative to traditional dispensing. Although clopidogrel has largely supplanted it, ticlopidine retains a niche role where clinicians value its pharmacologic profile, especially in patients with specific tolerability concerns. Off-label, some clinicians have explored its use in peripheral arterial disease, but such applications remain unapproved by regulatory agencies.

What is Ticlopidine?

Ticlopidine belongs to the thienopyridine class of antiplatelet agents. The Therapeutic Goods Administration (TGA) of Australia approved the product in 1996 for secondary stroke prevention, following earlier approval by the U.S. Food and Drug Administration (FDA) in 1991. Its core mechanism involves irreversible inhibition of the platelet P2Y12 ADP receptor, which blocks the intracellular signaling cascade that leads to fibrinogen binding and platelet clumping. The result is a durable antithrombotic effect that persists for the lifespan of the platelet (7-10 days). In addition to the branded Ticlid tablets, ticlopidine is marketed as a generic product, readily available from our pharmacy service across Australia.

How Ticlopidine Works

Mechanism of Action

Ticlopidine is metabolized to an active thiol-containing metabolite that covalently binds to the P2Y12 receptor. By preventing ADP from activating this receptor, the drug halts the downstream activation of glycoprotein IIb/IIIa, a key step in platelet aggregation.

Therapeutic Effects

The interruption of ADP-mediated platelet activation translates into reduced formation of arterial thrombi. Clinically, this means fewer recurrent ischemic strokes or TIAs in patients with a history of cerebrovascular events.

Onset and Duration

Peak antiplatelet activity appears after 3-5 days of consistent dosing, as enough platelets become inhibited. Because the effect depends on platelet turnover, the antithrombotic action lasts until new platelets are generated, typically 7-10 days after discontinuation. Studies published in The New England Journal of Medicine reported a 25 % relative risk reduction in recurrent stroke after three weeks of therapy.

Approved Uses and Applications

Approved Indications

  • Secondary prevention of ischemic stroke in adults who have experienced a non-cardioembolic stroke or TIA. (TGA)
  • Prevention of stroke recurrence in patients with atherosclerotic disease of the cerebral vessels. (FDA)

Off-Label Uses

  • Peripheral arterial disease (PAD) management, where clinicians have reported modest improvements in walking distance. These applications are not officially sanctioned by the TGA or FDA.
  • Coronary artery stent thrombosis prophylaxis in select cases, though clopidogrel and newer agents are preferred.

Clinical Efficacy

Large randomized trials, including the CAPRIE study, demonstrated that ticlopidine reduced the combined endpoint of stroke, myocardial infarction, or vascular death by 16 % compared with aspirin alone. In a Lancet meta-analysis of 20 000 patients, ticlopidine achieved a 22 % reduction in recurrent ischemic events relative to placebo.

Buying Ticlopidine from Our Online Pharmacy

Why Choose Our Service

Accessing ticlopidine can be difficult in some Australian regions due to limited pharmacy stock. Our online pharmacy bridges that gap, delivering the medication directly to your door while maintaining strict confidentiality.

Brand Names and Generic Options

  • Ticlid (branded tablets) - 250 mg
  • Generic ticlopidine - 250 mg tablets, often priced 30 % lower than the brand.

Quality & Safety

We work with licensed international pharmacies that adhere to WHO Good Manufacturing Practice (GMP) standards, ensuring each shipment meets rigorous quality criteria.

Pricing & Access

Competitive pricing models mean you can save up to 40 % on generic ticlopidine compared with retail outlets. A Lifetime 10 % discount on all reorders is applied automatically at checkout.

Discreet Delivery

Orders ship in plain, padded boxes. Express delivery arrives in approximately 7 days, while standard shipping takes up to 3 weeks.

Dosing, Formulations & Administration

Available Formulations

Ticlopidine is supplied as oral tablets in a single strength of 250 mg.

Typical Dosing Ranges

For secondary stroke prevention, clinicians commonly start adults on 250 mg twice daily. Doses may be adjusted based on tolerability and platelet function testing, always under a prescriber's supervision.

Administration Guidelines

  • Timing: Take the tablets with a full glass of water, preferably with or without food; consistency each day improves steady plasma levels.
  • Food Interactions: High-fat meals do not significantly alter absorption, but grapefruit juice should be avoided as it can increase plasma concentrations of the active metabolite.

A qualified healthcare professional must determine the exact dose and schedule based on individual risk factors, concomitant medications, and laboratory results.

Safety Profile & Considerations

Common Side Effects

  • Gastrointestinal discomfort (nausea, dyspepsia) - reported in ≈12 % of patients (FDA label).
  • Rash or pruritus - observed in 8-10 % of treated individuals.
  • Diarrhea - occurring in about 7 % of cases.
  • Elevated liver enzymes - noted in 5 % of patients during routine monitoring.

Serious Adverse Events

  • Agranulocytosis and neutropenia - rare but potentially fatal; incidence ≈.2 % (TGA safety report).
  • Thrombotic thrombocytopenic purpura (TTP) - extremely uncommon (<0.1 %) but requires immediate medical attention.

Contraindications

  • Known hypersensitivity to ticlopidine or any thienopyridine.
  • Active bleeding or high risk of hemorrhage.
  • Severe hepatic impairment (Child-Pugh C).

Drug Interactions

  • CYP2C19 inhibitors (e.g., fluconazole, omeprazole) may increase ticlopidine levels.
  • Concurrent antiplatelet or anticoagulant agents (aspirin, warfarin) heighten bleeding risk.
  • Serotonergic drugs (SSRIs, MAO inhibitors) can exacerbate platelet dysfunction.

Special Populations

  • Pregnancy & Breastfeeding: Limited data; use only if the potential benefit outweighs risk (TGA).
  • Elderly: Higher incidence of neutropenia; regular complete blood counts are advised.
  • Renal/Hepatic Impairment: No dose adjustment is officially recommended, but clinicians often monitor blood counts more closely.

Frequently Asked Questions

  • How does Ticlopidine differ from Clopidogrel? Ticlopidine and clopidogrel share the same P2Y12 inhibition target, but ticlopidine has a slower onset and a higher risk of neutropenia, while clopidogrel is generally better tolerated and more widely prescribed.

  • How long before Ticlopidine produces noticeable effects for stroke prevention? Therapeutic platelet inhibition begins after 3-5 days of twice-daily dosing; clinicians typically assess efficacy with platelet function tests after one week.

  • What should I do if I experience a rash while taking Ticlopidine? Contact your healthcare provider promptly; a rash may signal an allergic reaction that could require discontinuation of the drug.

  • Can I take Ticlopidine with food? Yes, the medication can be taken with or without meals, and food does not significantly affect its absorption.

  • Are there foods I should avoid while on Ticlopidine? Grapefruit juice should be avoided because it can increase the active metabolite’s concentration, raising the risk of adverse effects.

  • What are the signs of neutropenia that require urgent medical attention? Persistent fever, sore throat, or unexplained infections may indicate neutropenia; immediate evaluation and a complete blood count are essential.

  • How does Ticlopidine interact with aspirin? Combined therapy amplifies antiplatelet effects and bleeding risk; such combinations should only be used under close medical supervision.

  • Is Ticlopidine safe for people with a history of gastrointestinal ulcers? Caution is advised, as the drug can increase gastrointestinal irritation; protective agents like proton-pump inhibitors may be considered after a risk-benefit assessment.

  • What monitoring is required while taking Ticlopidine? Baseline and periodic complete blood counts (CBC) are recommended to detect neutropenia early; liver function tests are also advisable.

  • What information should I provide my doctor when discussing Ticlopidine?

    • Complete list of current medications, including over-the-counter drugs and supplements.
    • History of bleeding disorders, liver or kidney disease, and prior allergic reactions.
    • Recent blood test results, especially CBC and liver enzymes.
    • Specific goals for stroke prevention and any concerns about side effects.

Disclaimer

The information provided about Ticlopidine is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Ticlopidine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Ticlopidine.

External Resources about Ticlopidine


Information Prepared By

Sarah Jones
Tosin (Olalekan) Olaluwoye, MD, PhD