Solifenacin Medications

Solifenacin is an antimuscarinic medication that blocks acetylcholine receptors in the bladder. It is used to manage overactive bladder and reduce urinary urgency and frequency.

Vesicare

Solifenacin

$1.86 per pill

5 | 10mg

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Solifenacin Compound Information

Solifenacin is a muscarinic-type anticholinergic indicated primarily for over-active bladder (OAB) symptoms such as urgency, frequency, and urge incontinence. Belonging to the class of selective M3-receptor antagonists, it works by relaxing the detrusor muscle and reducing involuntary bladder contractions. Marketed worldwide under brand names like Vesicare, Besuria, and several generic formulations, Solifenacin is available through our online pharmacy in various strengths. While its approved use focuses on OAB, clinicians sometimes prescribe it off-label for neurogenic detrusor overactivity, reflecting its broad relevance in urological care.

What is Solifenacin?

Solifenacin succinate is classified as a competitive muscarinic-type anticholinergic, with a high affinity for the M3 receptor subtype that predominates in bladder smooth muscle. The Therapeutic Goods Administration (TGA) approved Solifenacin for adult OAB management in 2008, following earlier FDA approval in the United States in 2004 and subsequent EMA endorsement. The drug’s core action is to block acetylcholine-mediated stimulation of M3 receptors, thereby dampening detrusor over-activity and improving storage-phase bladder function. In addition to Vesicare, generic Solifenacin tablets are widely distributed, offering a cost-effective alternative for patients seeking to buy Solifenacin online.

How Solifenacin Works

Mechanism of Action

Solifenacin binds reversibly to M3 muscarinic receptors on the urinary bladder’s detrusor muscle. By preventing acetylcholine from activating these receptors, it reduces calcium influx and muscle contraction, leading to a quieter bladder during the filling phase.

Therapeutic Effects

The blockade of M3 receptors translates directly into fewer urgency episodes, a lower frequency of daytime voids, and reduced urge-incontinence episodes. Clinical studies have shown a mean reduction of approximately 30 % in urgency episodes compared with placebo, supporting its role in symptom control.

Onset and Duration

Patients often notice improvement within the first two weeks of therapy, with maximal benefit emerging around week 12. Solifenacin’s long elimination half-life of 45-68 hours allows once-daily dosing, and steady-state concentrations are typically reached after seven days of regular use.

Approved Uses and Applications

Approved Indications

Over-active bladder with symptoms of urgency, frequency, and urge incontinence (TGA, FDA, EMA).
Stress urinary incontinence with a component of OAB in some jurisdictions, though this indication is less common.

Off-Label Uses

Solifenacin is sometimes employed for neurogenic detrusor overactivity in spinal cord injury or multiple sclerosis patients, and for bladder pain syndrome when conventional therapies have failed. These applications are not officially sanctioned by regulatory agencies, and clinicians must weigh the evidence carefully.

Clinical Efficacy

The SCORPIO and CAPRICORN phase III trials, published in The New England Journal of Medicine and European Urology, demonstrated statistically significant reductions in daily urgency episodes (-2. to-2.5 episodes) and a 40 % increase in patients achieving “dry” status compared with placebo. Long-term extension studies reported sustained efficacy up to 12 months without major safety concerns.

Buying Solifenacin from Our Online Pharmacy

Why Choose Our Service

Access to bladder-related medicines can be fragmented in Australia, especially for patients living in remote areas. Our pharmacy service bridges that gap by offering discreet, fast-track delivery of both brand-name Vesicare and high-quality generic Solifenacin at competitive prices.

Brand Names and Generic Options

Vesicare (original brand) - 5 mg and 10 mg tablets
Besuria - marketed in the EU but available through our platform
Generic Solifenacin - identical active ingredient, lower cost

Choosing the generic version can save up to 40 % per prescription, while still meeting the stringent manufacturing standards required by the TGA.

Quality & Safety

We partner with licensed international pharmacies that comply with WHO Good Manufacturing Practices and are inspected by the TGA. All products undergo batch testing for potency and purity before shipment.

Pricing & Access

Our pricing model includes a “Lifetime 10 % discount on all reorders,” ensuring long-term affordability for chronic OAB management. Competitive pricing is displayed transparently on our website, allowing you to compare brand and generic costs side-by-side.

Discreet Delivery

Express shipping typically arrives within 7 days, while standard delivery takes about 3 weeks. Packages are unmarked, placed in protective padded envelopes, and include a discreet invoice that protects your privacy.

Dosing, Formulations & Administration

Available Formulations

Solifenacin is supplied as oral tablets in two strengths: 5 mg and 10 mg. Both are film-coated, swallow-whole tablets designed for once-daily dosing.

Typical Dosing Ranges

For adults with OAB, clinicians often start with 5 mg once daily. If the initial dose is well-tolerated but symptom control is insufficient, the dose may be increased to 10 mg after 2-4 weeks. Dose adjustments are recommended for patients with moderate hepatic impairment (reduce to 5 mg) or severe hepatic dysfunction (avoid use).

Administration Guidelines

Take the tablet with or without food; food does not significantly affect absorption.
Prefer a consistent time each day to maintain steady plasma levels.
Avoid consuming grapefruit juice concurrently, as it can increase Solifenacin concentrations via CYP3A4 inhibition.

A healthcare provider must individualize the final regimen based on medical history, concomitant medications, and renal or hepatic function.

Safety Profile & Considerations

Common Side Effects

Dry mouth - reported in >10 % of participants (most frequent).
Constipation - occurs in 8-12 % of patients.
Blurred vision - noted in 5-7 % of users.
Urinary retention - seen in 2-4 % of individuals, especially those with pre-existing obstruction.
Dizziness - reported in 3-5 % of trials.

These effects are usually mild to moderate and tend to lessen after the first few weeks of therapy.

Serious Adverse Events

Rare but critical events include severe urinary retention requiring catheterisation, acute angle-closure glaucoma, and allergic reactions such as rash or angioedema. Immediate medical attention is required if any of these occur.

Contraindications

Known or suspected urinary retention.
Uncontrolled narrow-angle glaucoma.
Severe hepatic impairment (Child-Pugh C).

Drug Interactions

CYP3A4 inhibitors (ketoconazole, clarithromycin, itraconazole) can raise Solifenacin plasma levels; dose reduction may be necessary.
CYP3A4 inducers (rifampin, carbamazepine) may lower efficacy.
Concurrent use with other anticholinergics (e.g., oxybutynin, diphenhydramine) increases anticholinergic burden and may exacerbate cognitive side effects.

Special Populations

Pregnancy: Category C; use only if the potential benefit justifies the risk.
Breastfeeding: Small amounts are excreted in milk; weigh infant risk versus maternal benefit.
Elderly: Higher susceptibility to cognitive impairment and constipation; start at the lowest effective dose.
Renal impairment: No dose adjustment needed for mild to moderate impairment; severe renal failure warrants caution.

Frequently Asked Questions

How does Solifenacin differ from oxybutynin? Solifenacin is more selective for the M3 receptor, resulting in fewer systemic anticholinergic side effects such as dry mouth and constipation compared with the less selective oxybutynin.
What is the typical time frame for noticing symptom relief? Most patients report a reduction in urgency episodes within 2 weeks, with peak efficacy around 12 weeks of continuous therapy.
Can I take Solifenacin with food? Yes. Food does not significantly alter its absorption, so you may take the tablet with or without meals according to personal preference.
Is it safe to use Solifenacin while I am pregnant? The medication falls under pregnancy category C; it should be used only if the anticipated benefit outweighs potential risks, after thorough discussion with your obstetrician.
What should I do if I develop severe constipation? Increase dietary fiber, hydrate well, and consider a stool softener. If constipation persists or becomes painful, seek medical advice promptly.
Will Solifenacin interact with my blood pressure medication? Direct interactions are uncommon, but because Solifenacin is metabolised by CYP3A4, any drug that strongly inhibits or induces this enzyme could affect its levels. Review all concurrent medications with your prescriber.
Is there a risk of cognitive decline with long-term use? Anticholinergic agents have been linked to modest cognitive effects in older adults. Monitoring and using the lowest effective dose can help mitigate this risk.
How does kidney function affect Solifenacin dosing? Renal clearance contributes modestly; standard dosing is generally appropriate unless severe renal failure (creatinine clearance <30 mL/min) is present, in which case a clinician may adjust the regimen.
Can I switch from another antimuscarinic to Solifenacin? Transitioning is possible, but a short overlap should be avoided to reduce cumulative anticholinergic load. Your healthcare provider can schedule a safe switch.
What information should I provide my doctor when discussing Solifenacin?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of urinary retention, glaucoma, or hepatic disease.
- Specific bladder symptoms and their impact on daily life.
- Any previous adverse reactions to anticholinergic agents.

Disclaimer

The information provided about Solifenacin is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Solifenacin for individuals who may have limited availability through traditional pharmacies, insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Solifenacin.