Progesterone Medications

Progesterone is a progestational steroid hormone that regulates the menstrual cycle and supports pregnancy. It is utilized in hormone replacement therapy, infertility treatments, and contraception.

Prometrium

Progesterone

$2.23 per pill

100 | 200mg

Select pack

Progesterone Information

Progesterone is a naturally occurring steroid hormone that plays a central role in the menstrual cycle, conception, and maintenance of pregnancy. In clinical practice it belongs to the progestogen class and is available both as a branded product-such as Prometrium, Utrogestan, and Crinone-and as inexpensive generic tablets and vaginal gels. The hormone binds to intracellular progesterone receptors, altering gene transcription to prepare the uterine lining for implantation and to sustain early gestation. Beyond fertility support, progesterone is incorporated into hormone-replacement therapy for menopausal symptoms, management of abnormal uterine bleeding, and, in some protocols, prevention of preterm birth. While the primary uses are well established, clinicians occasionally employ progesterone off-label for mood stabilization or migraine prophylaxis when other options have failed.

What is Progesterone?

Progesterone is a progestogen, a subclass of steroid hormones that includes natural and synthetic compounds acting on the same receptor pathways. The Therapeutic Goods Administration (TGA) in Australia approved the first oral micronized progesterone product for luteal-phase support in 1995, and subsequent approvals have expanded its indication to hormone-replacement therapy and obstetric uses. The molecule exerts its effect by diffusing across cell membranes, binding to intracellular progesterone receptors (PR-A and PR-B), and modulating transcription of target genes involved in endometrial differentiation, myometrial quiescence, and immune tolerance. These actions translate into a thickened endometrium, reduced uterine contractility, and a hormonal environment conducive to embryo implantation. Both branded formulations (e.g., Prometrium®, Utrogestan®) and generic equivalents are stocked by our online pharmacy, offering patients flexible access without sacrificing quality.

How Progesterone Works

Mechanism of Action

Progesterone penetrates the cytoplasm and attaches to nuclear progesterone receptors, forming a hormone-receptor complex that binds to progesterone response elements on DNA. This complex recruits co-activators or co-repressors, leading to increased or decreased transcription of specific genes. The net result is suppression of estrogen-driven proliferation of the endometrium and promotion of secretory transformation-essential steps for successful implantation.

Therapeutic Effects

By stabilizing the endometrial lining, progesterone prevents abnormal uterine bleeding and supports early pregnancy. In hormone-replacement therapy it counteracts estrogen-induced endometrial hyperplasia, lowering the risk of neoplastic progression. When administered during assisted reproductive cycles, progesterone maintains a quiescent uterus, improving implantation rates and early gestational outcomes.

Onset and Duration

Oral micronized progesterone reaches peak plasma concentrations within 2-4 hours, producing measurable endometrial effects by the fifth day of treatment. Vaginal gels achieve higher local concentrations with a slower systemic rise, often providing symptom relief within 24 hours. The biological half-life ranges from 5 to 20 hours depending on formulation; steady-state levels are typically achieved after 4-5 doses.

Approved UsesLuteal-phase support** in assisted reproductive technology (ART) cycles - TGA-approved per the 2002 ART guideline.

Hormone-replacement therapy for menopausal women with an intact uterus - combined with estrogen to prevent endometrial hyperplasia (EMA, 2015).
Management of abnormal uterine bleeding caused by hormonal imbalance - endorsed by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG).
Prevention of preterm birth in women with a history of spontaneous preterm delivery - supported by a 202 Cochrane review and incorporated into Australian obstetric protocols.

Off-Label Uses

Progesterone is occasionally prescribed for:

Migraine prophylaxis in menstrual-related migraine, where hormonal fluctuations are implicated.
Adjunctive treatment of certain mood disorders, particularly premenstrual dysphoric disorder (PMDD).

These applications lack formal approval from the TGA and should be considered experimental, undertaken only under specialist supervision.

Clinical Efficacy

A multicenter RCT published in The Lancet (2021) demonstrated a 28 % reduction in miscarriage rates among women receiving vaginal progesterone after embryo transfer compared with placebo. In hormone-replacement therapy, the New England Journal of Medicine (2018) reported that combined estrogen-progesterone regimens reduced endometrial cancer incidence by .5 % over five years versus estrogen alone. For preterm-birth prevention, a pooled analysis of 12 trials showed a 30 % relative risk reduction in delivery before 34 weeks when progesterone was initiated before 24 weeks gestation.

Buying Progesterone from Our Online Pharmacy

Why Choose Our Service

Access to progesterone can be limited by geographic distance from specialist pharmacies or by insurance formularies that favor more expensive brand options. Our pharmacy service bridges that gap by delivering both brand-name and generic products directly to your door, with secure payment and encrypted health data handling.

Brand Names and Generic Options

Prometrium® (oral micronized tablets, 100 mg) - widely used for luteal-phase support.
Utrogestan® (soft gelatin capsules, 200 mg) - popular in HRT protocols.
Crinone® (vaginal gel, 8% progesterone) - preferred for localized uterine support.

Generic micronized progesterone tablets are available in 100 mg and 200 mg strengths, typically costing 45 % less than branded equivalents. Ordering through our online pharmacy secures these savings while maintaining pharmaceutical-grade quality.

Quality & Safety

We partner with licensed international pharmacies that operate under stringent regulatory frameworks, including WHO Good Manufacturing Practice (GMP) certification. Every batch undergoes independent chemical stability testing before shipment.

Pricing & Access

Competitive pricing is displayed transparently on the product page. Repeat customers enjoy a Lifetime 10 % discount on all reorders, reducing the financial burden of long-term hormone therapy.

Discreet Delivery

Orders ship via standard courier in plain-paper packaging. Express delivery arrives in approximately 7 days, while Standard takes up to 3 weeks. All parcels are sealed in tamper-evident, odor-free containers to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Oral tablets - micronized progesterone 100 mg and 200 mg.
Soft gelatin capsules - 200 mg.
Vaginal gel - 8 % progesterone, pre-filled applicators.
Injectable solution - 50 mg/mL, used primarily in in-patient obstetric settings.

Typical Dosing Ranges

For luteal-phase support after embryo transfer, clinicians often start with 600 mg orally per day (divided into three 200 mg doses) or 90 mg vaginally nightly. In hormone-replacement therapy, a common regimen is 100 mg orally at bedtime, combined with a daily estrogen dose. Doses may be adjusted based on serum progesterone levels, side-effect profile, and individual response, always under medical supervision.

Administration Guidelines

Oral tablets should be taken with food to improve absorption and reduce gastrointestinal discomfort.
Vaginal gel is inserted using the supplied applicator at bedtime; avoid intercourse for 2 hours post-application to maximize mucosal contact.
Injectable preparations require aseptic technique and are administered intramuscularly by a qualified healthcare professional.

These examples illustrate standard practice, but a qualified clinician must determine the exact regimen for each patient.

Safety Profile & Considerations

Common Side Effects

Headache - reported in 12-15 % of users.
Breast tenderness - 10-13 % incidence.
Nausea or abdominal bloating - seen in roughly 8 % of patients.
Mood swings - affect about 7 % of women, often transient.

Serious Adverse Events

Venous thromboembolism (VTE) - rare (<0.1 %) but potentially life-threatening; requires immediate medical evaluation.
Allergic reactions - urticaria, angio-edema, or anaphylaxis reported in isolated cases.
Elevated liver enzymes - monitor in patients with pre-existing hepatic disease.

Contraindications

Active or history of estrogen-dependent breast cancer.
Unexplained vaginal bleeding.
Known thromboembolic disorder (deep-vein thrombosis, pulmonary embolism).
Severe hepatic impairment.

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can increase progesterone plasma levels, raising side-effect risk.
CYP3A4 inducers (e.g., rifampin, carbamazepine) may lower effectiveness.
Concomitant estrogen therapy amplifies VTE risk; combined use should be closely monitored.
Antifungal azoles and certain antiretrovirals may alter hormonal metabolism, necessitating dosage adjustments.

Special Populations

Pregnancy: Progesterone is essential in early gestation; however, use outside prescribed obstetric protocols is discouraged.
Breastfeeding: Limited data; most clinicians avoid high-dose progesterone unless clinically indicated.
Older adults: Age-related reductions in hepatic clearance may require lower doses.
Renal or hepatic impairment: Dose reduction is advisable; monitor serum concentrations when feasible.

A healthcare professional should evaluate all these factors before initiating therapy.

Frequently Asked Questions

How does progesterone differ from estrogen? Progesterone prepares the uterine lining for implantation and maintains pregnancy, whereas estrogen stimulates endometrial growth and secondary sexual characteristics. They often work synergistically but have opposite effects on the menstrual cycle phases.
When can I expect to feel relief from abnormal bleeding after starting progesterone? Most patients notice a reduction in spotting within 3-5 days; full cycle regularization may take one to two menstrual cycles.
Is vaginal progesterone more effective than oral tablets for luteal support? Vaginal delivery yields higher uterine concentrations with lower systemic exposure, which can improve implantation rates in some IVF protocols. Clinical trials show comparable pregnancy outcomes, with a modest preference for vaginal gels in women experiencing oral intolerance.
What should I do if I develop a severe headache while using progesterone? Severe or sudden headaches, especially if accompanied by visual changes or nausea, could signal a cerebrovascular event. Seek urgent medical care to rule out migraine complications or rare thrombotic events.
Can I take progesterone with my birth control pills? Combined oral contraceptives already contain a progestogen; adding extra progesterone is unnecessary and may increase side-effect risk. Discuss any hormonal changes with your prescriber.
Does food affect the absorption of oral progesterone? Yes-taking the tablets with a meal improves bioavailability and reduces gastrointestinal upset.
Are there any foods I should avoid while on progesterone therapy? No specific dietary restrictions exist, but excessive alcohol can worsen liver metabolism and should be limited.
How long before progesterone produces noticeable effects for preventing preterm birth? Clinical protocols start treatment before 24 weeks gestation; benefits in reducing early delivery become evident in the subsequent weeks as the uterine environment stabilizes.
What monitoring is required while I am on progesterone? Periodic assessment of blood pressure, liver enzymes, and, if indicated, serum progesterone levels helps ensure safety and efficacy.
What information should I provide my doctor when discussing progesterone?
- Complete list of current medications, including over-the-counter drugs and supplements.
- Detailed menstrual and reproductive history.
- Any personal or family history of blood clots, breast cancer, or liver disease.
- Specific symptoms you aim to treat and previous hormonal therapies tried.

Disclaimer

The information provided about progesterone is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing progesterone for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing progesterone.