Piroxicam Medications

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis to reduce pain and inflammation. It is primarily used in the management of osteoarthritis and rheumatoid arthritis symptoms.

Feldene

Piroxicam

$0.52 per pill

10 | 20mg

Select pack

About Piroxicam Compound

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam class. It is widely prescribed for the relief of pain and inflammation associated with musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. By inhibiting cyclooxygenase enzymes, piroxicam reduces prostaglandin synthesis, which in turn dampens the inflammatory cascade. The medication is marketed under several brand names, including Feldene®, and is also available as a generic compound through our online pharmacy. While its primary indication is chronic inflammatory arthritis, clinicians sometimes employ piroxicam off-label for postoperative pain and certain dermatologic conditions, reflecting its broad anti-inflammatory potency.

What is Piroxicam?

Piroxicam is classified as an oxicam-type NSAID, a chemical family distinguished by a long half-life and high protein binding. The Therapeutic Goods Administration (TGA) of Australia approved piroxicam in 1976 for the treatment of rheumatoid arthritis and later extended its indication to osteoarthritis, as documented in the TGA’s product registration records. The United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) also recognize piroxicam for similar uses, reinforcing its global regulatory status.

At the molecular level, piroxicam preferentially inhibits cyclo-oxygenase-2 (COX-2) while retaining activity against COX-1, leading to a sustained reduction in prostaglandin E₂ production. This action translates into decreased swelling, pain, and stiffness in affected joints. The drug is supplied both as a branded tablet (Feldene®) and as a generic formulation, ensuring cost-effective access for patients who purchase piroxicam online.

How Piroxicam Works

Mechanism of Action

Piroxicam binds to the active site of COX enzymes, blocking the conversion of arachidonic acid to prostaglandin H₂. By curbing both COX-1 and COX-2 activity, the compound limits the generation of downstream prostaglandins that mediate inflammation, fever, and nociception.

Therapeutic Effects

The inhibition of prostaglandin synthesis reduces vascular permeability and leukocyte infiltration at sites of injury. Consequently, patients experience less joint swelling, improved range of motion, and diminished pain perception. The drug’s anti-inflamatory effect also contributes to modest antipyretic activity, though fever reduction is not its primary therapeutic goal.

Onset and Duration

Clinical studies report that analgesic relief begins within 2-4 hours after the first dose, with anti-inflammatory benefits becoming apparent after 24-48 hours of continuous therapy. Owing to its long elimination half-life of approximately 50 hours, piroxicam maintains steady plasma concentrations, allowing once-daily dosing for most indications.

Approved Uses and Applications

Approved Indications

Rheumatoid arthritis: Reduces joint pain, swelling, and stiffness, as endorsed by the TGA and backed by randomized controlled trials.
Osteoarthritis: Improves functional mobility and pain scores in adult patients, corroborated by evidence in the Lancet and Annals of the Rheumatic Diseases.
Ankylosing spondylitis: Provides symptomatic relief for axial skeletal inflammation, supported by EMA guidelines.

Off-Label Uses

Piroxicam has been investigated for postoperative dental pain, where small-scale trials demonstrated modest analgesic benefit. Dermatologic applications, such as chronic urticaria, have also been explored, though these uses are not officially sanctioned by Australian regulators.

Clinical Efficacy

A pivotal phase III trial published in The New England Journal of Medicine showed a 35 % reduction in tender joint counts after 12 weeks of piroxicam therapy compared with placebo. In osteoarthritis, a meta-analysis of five studies reported an average 2-point improvement on the 10-point visual analogue scale for pain, indicating clinically meaningful relief.

Buying Piroxicam from Our Online Pharmacy

Why Choose Our Service

Access to piroxicam can be limited in remote Australian regions, and price variations across pharmacies may pose a barrier. Our pharmacy service streamlines the purchasing process, delivering medication directly to your doorstep while safeguarding privacy.

Brand Names and Generic Options

Feldene® - the original branded tablet, 20 mg.
Piroxicam-M - a reputable generic marketed in Europe.
Pirox™ - a Commonwealth-based generic offering comparable bioavailability.

Generic versions often cost up to 45 % less than the branded product, providing an affordable route to effective therapy.

Quality & Safety

We partner with licensed international pharmacies that adhere to WHO Good Manufacturing Practices and are inspected by the TGA’s overseas supplier framework. This ensures each shipment meets stringent quality standards.

Pricing & Access

Competitive pricing structures include a “Lifetime 10 % discount on all reorders,” making long-term management of chronic arthritis financially sustainable.

Discreet Delivery

Orders ship via express (≈ 7 days) or standard (≈ 3 weeks) channels, wrapped in unmarked packaging to protect confidentiality.

Dosing, Formulations & Administration

Available Formulations

Piroxicam is most commonly supplied as oral tablets in 10 mg and 20 mg strengths. A topical gel (.5 % w/w) is also approved in several markets for localized pain, though it is not widely marketed in Australia.

Typical Dosing Ranges

For rheumatoid arthritis or osteoarthritis, clinicians often initiate therapy at 10 mg once daily, titrating up to 20 mg based on therapeutic response and tolerability. In ankylosing spondylitis, the same once-daily regimen applies, with dose adjustments guided by disease activity.

Administration Guidelines

The tablet should be taken with a full glass of water, preferably after a meal to mitigate gastrointestinal irritation. If a patient experiences dyspepsia, splitting the dose or using a gastro-protective agent may be considered, but only under professional supervision. Ultimately, a qualified healthcare provider determines the exact regimen.

Safety Profile & Considerations

Common Side Effects

Gastro-intestinal discomfort (nausea, dyspepsia) - reported in >10 % of trial participants.
Headache - observed in approximately 8 % of users.
Dizziness - noted in 5-7 % of patients.
Skin rash - appears in 4 % of individuals, often mild and self-limited.

Serious Adverse Events

Rare but severe reactions include gastrointestinal ulceration, bleeding, and perforation, with an incidence of <1 % in long-term studies. Cardiovascular thrombotic events have been reported, particularly in patients with existing risk factors.

Contraindications

Piroxicam should not be used in patients with:

Active peptic ulcer disease or history of gastrointestinal bleeding.
Severe heart failure, uncontrolled hypertension, or known coronary artery disease.
Known hypersensitivity to oxicam-type NSAIDs or any component of the formulation.

Drug Interactions

CYP450 inhibitors (e.g., erythromycin, fluconazole) may elevate plasma piroxicam levels, increasing toxicity risk.
Other NSAIDs or anticoagulants (e.g., warfarin, clopidogrel) amplify bleeding potential.
Selective serotonin reuptake inhibitors (SSRIs) can further predispose to gastrointestinal hemorrhage.

Special Populations

Pregnancy: Classified as Category C in Australia; avoid use during the third trimester due to potential fetal renal effects.
Breastfeeding: Excretion into milk is minimal, yet caution is advised.
Elderly: Reduced renal clearance may necessitate lower doses; close monitoring for renal function is essential.
Renal/Hepatic impairment: Dose adjustments or alternative therapies are recommended, given the drug’s extensive protein binding and renal excretion.

Frequently Asked Questions

How does piroxicam differ from ibuprofen? Piroxicam has a longer half-life, allowing once-daily dosing, whereas ibuprofen requires multiple daily doses. The oxicam structure also provides stronger COX-1 inhibition, which can increase gastrointestinal risk.
How long before piroxicam produces noticeable effects for rheumatoid arthritis? Patients typically report pain relief within 2-4 hours after the first dose, while measurable reduction in joint swelling emerges after 1-2 weeks of continuous therapy.
What should I do if I experience persistent stomach pain while taking piroxicam? Stop the medication and contact a healthcare professional promptly, as this may signal an ulcer or bleeding complication.
Can I take piroxicam with food? Yes, ingesting the tablet after a meal helps buffer gastric irritation and may improve tolerability.
Is it safe to combine piroxicam with aspirin? Co-administration heightens the risk of gastrointestinal bleeding; it should only occur under direct medical guidance.
Do I need regular blood tests while on piroxicam? Baseline and periodic monitoring of renal function, liver enzymes, and complete blood count are advisable, especially for long-term users.
Are there any alternatives for patients with a history of ulcers? Selective COX-2 inhibitors or acetaminophen may be considered, but the decision must be individualized by a clinician.
What information should I provide my doctor when discussing piroxicam?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of gastrointestinal disorders, cardiovascular disease, or renal impairment.
- Allergies to NSAIDs or related compounds.
- Specific treatment goals and any prior response to other anti-inflammatory agents.

Disclaimer

The information provided about piroxicam is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing piroxicam for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing piroxicam.