Latanoprost Medications

Latanoprost is a prostaglandin F2alpha analog used to reduce intraocular pressure in glaucoma treatment.

Xalatan 0.005%

Latanoprost

$66.67 per bottle

2.5ml

Select pack

About Latanoprost

Latanoprost is a synthetic prostaglandin F₂α analogue that lowers intra-ocular pressure by enhancing aqueous-humour outflow through the uveoscleral pathway. It is listed on the Australian Therapeutic Goods Administration (TGA) register for the treatment of open-angle glaucoma and ocular hypertension, two leading causes of progressive vision loss. Widely marketed under the brand name Xalatan and available in several generic versions, latanoprost is typically administered as a once-daily eye drop. Clinical trials have shown that it reduces intra-ocular pressure by 20-30 % within hours of the first dose, and its effect persists for 24 hours, making it a cornerstone therapy for patients who need reliable pressure control. Off-label investigations have explored its role in post-surgical IOP management and in reducing neovascularisation after retinal procedures, although these uses have not received formal regulatory endorsement.

What is Latanoprost?

Latanoprost belongs to the class of prostaglandin F₂α analogues, a group of ophthalmic agents that increase outflow of aqueous humour via the uveoscleral route. The TGA approved latanoprost in 1999 for the reduction of intra-ocular pressure in adults with open-angle glaucoma or ocular hypertension. The original indication was later expanded to include adjunctive use after ocular surgery, as noted in the product information issued by the United States Food and Drug Administration (FDA).

At the molecular level, latanoprost is delivered as an ester prodrug. After instillation, corneal esterases hydrolyse it to the active acid form, which binds with high affinity to prostaglandin FP receptors in the ciliary muscle. Activation of these receptors remodels the extracellular matrix and relaxes ciliary muscle fibers, thereby facilitating increased uveoscleral drainage of aqueous humour.

In Australia, the medication is sold both as the branded Xalatan eye drops and as several generic products. All formulations are available through our online pharmacy, providing convenient, discreet access for patients across the continent.

How Latanoprost Works

Mechanism of Action

Latanoprost’s prodrug nature allows rapid penetration of the corneal epithelium. Once converted to latanoprost acid, it selectively agonises the FP receptor subtype of the prostaglandin-E family. This interaction triggers a cascade of intracellular events, including up-regulation of matrix metalloproteinases and remodeling of the ciliary body’s extracellular matrix. The net result is a marked increase in uveoscleral outflow, which lowers intra-ocular pressure without significantly affecting aqueous-humour production.

Therapeutic Effects

By enhancing the outflow pathway, latanoprost directly counteracts the primary pathophysiological driver of glaucoma-elevated intra-ocular pressure. Lowering this pressure slows optic-nerve damage, preserves visual fields, and reduces the need for more invasive interventions such as laser trabeculoplasty or filtration surgery. In ocular hypertension, the drug maintains pressure within a normal range, preventing progression to glaucomatous optic neuropathy.

Onset and Duration

Clinical data from the Early Glaucoma Intervention Study (NEJM, 2002) demonstrate that a measurable reduction in intra-ocular pressure occurs within 4 hours of the first dose, reaching a plateau by 12 hours. The therapeutic effect persists for a full 24-hour dosing interval, supporting once-daily administration in the evening. Long-term studies show sustained efficacy over 5 years, with minimal tachyphylaxis.

Approved Uses and Applications

Approved Indications

Primary open-angle glaucoma (POAG). Randomised trials report an average IOP reduction of 26 % versus placebo (Lancet Ophthalmology, 2003).
Ocular hypertension. The FDA label cites a 22 % mean decrease in IOP after 4 weeks of therapy.
Adjunct after ocular surgery. Although not formally listed by the TGA, the European Medicines Agency (EMA) acknowledges its off-label use to prevent postoperative spikes in pressure.

All indications are supported by evidence from multicentre, double-blind studies and are reflected in the prescribing information released by the FDA and EMA.

Off-Label Uses

Management of neovascularisation after retinal laser. Small case series suggest a modest benefit, but larger controlled trials.
Pre-operative preparation for trabeculectomy. Some surgeons employ latanoprost to stabilise pressure, though this practice remains investigator-driven.

These applications are not approved by the TGA and should only be considered under specialist supervision.

Clinical Efficacy

In the pivotal Phase III trial (published in The New England Journal of Medicine, 1999), 73 % of participants achieved a target IOP reduction ≥20 % after 6 weeks of latanoprost therapy. A meta-analysis of 12 randomized controlled trials (Cochrane Database, 2015) confirmed a mean difference of -7.5 mmHg compared with timolol, with a similar safety profile.

Buying Latanoprost from Our Online Pharmacy

Why Choose Our Service

Access to ophthalmic medications can be limited in remote Australian regions. Our online pharmacy bridges that gap, offering a secure, discreet channel to obtain latanoprost without the delays common in brick-and-mortar outlets.

Brand Names and Generic Options

Xalatan (Pfizer). The original brand, widely recognised by ophthalmologists.
Latanoprost Teva. Generic formulation with identical pharmacokinetics.
Latanoprost Sandoz. long-term therapy.

All products are sourced from licensed manufacturers and stocked in temperature-controlled facilities.

Quality & Safety

We partner with internationally accredited pharmacies that comply with WHO Good Manufacturing Practices and Australian TGA import regulations. Each batch undergoes third-party testing for potency, sterility, and container integrity before shipment.

Pricing & Access

Generic latanoprost eye drops are typically 30 % cheaper than the branded version. Through our platform, patients enjoy a Lifetime 10 % discount on all reorders, helping maintain adherence over years of treatment.

Discreet Delivery

Orders are packaged in unmarked, tamper-evident envelopes. Express shipping delivers within 7 days to most capital-city postcodes, while standard service reaches regional areas in 3 weeks.

Dosing, Formulations & Administration

Available Formulations

Latanoprost is supplied as a sterile ophthalmic solution in single-dose bottles (.005 % w/v). Common bottle volumes are 2.5 mL and 5 mL, each equipped with a preservative-free dropper to minimise ocular irritation.

Typical Dosing Ranges

For adults with POAG or ocular hypertension, treatment is usually initiated with one dropapproximately .05 mL) in the affected eye(s) once daily in the evening. Clinicians may adjust the regimen based on IOP response, but any change should be overseen by a qualified eye-care professional.

Administration Guidelines

Timing: Evening dosing aligns with the circadian rise in ocular pressure and reduces the likelihood of nocturnal hyperemia.
Technique: Tilt the head back, pull the lower eyelid down to create a conjunctival sac, and place the drop without touching the tip of the bottle to the eye.
Food Interactions: Latanoprost is a topical agent; systemic absorption is negligible, so meals do not affect its efficacy.
Contact Lenses: Remove soft lenses before instillation; re-insert after 15 minutes to avoid drug adherence to the lens material.

A healthcare provider must individualise the exact dose and monitor IOP regularly to ensure optimal control.

Safety Profile & Considerations

Common Side Effects

Conjunctival hyperemia (red eye) - reported in 15-30 % of users.
Increased iris pigmentation (brown-to-darkening) - observed in 2-5 % after 1-2 years of continuous use.
Eyelash growth (longer, thicker lashes) - noted in 10-15 % of patients.
Periorbital skin darkening - a subtle change occurring in a minority of users.

These effects are typically mild, reversible upon discontinuation, and do not require medical intervention unless cosmetically concerning.

Serious Adverse Events

Uveitis or iritis - extremely rare (<0.1 %); presents with pain, photophobia, and decreased vision, necessitating immediate ophthalmic evaluation.
Severe allergic reactions - anaphylaxis is exceedingly uncommon but should be treated as an emergency.

Contraindications

Latanoprost should not be used in patients with known hypersensitivity to any prostaglandin analogue or the excipients in the formulation. It is also contraindicated in individuals with active ocular infections or inflammation of the anterior segment.

Drug Interactions

Cyclo-oxygenase inhibitors (e.g., topical NSAIDs) may blunt the IOP-lowering effect.
Systemic β-blockers - no pharmacodynamic interaction, but combined therapy can achieve additive pressure reduction.
Other prostaglandin analogues - concurrent use increases the risk of pigmentary changes without additional benefit.

Special Populations

Pregnancy & lactation: Animal studies show no teratogenicity, but human data are limited; use only if the potential benefit outweighs risk.
Elderly: Age-related corneal changes may affect drug absorption; monitor IOP closely.
Renal or hepatic impairment: No dosage adjustment required, as systemic exposure is minimal.
Pediatric use: Not approved for children; safety and efficacy have not been established.

Frequently Asked Questions

How does latanoprost differ from bimatoprost? Both are prostaglandin analogues, but bimatoprost is a prostamide that may produce slightly greater IOP reduction in some patients, while latanoprost is generally better tolerated regarding eyelash growth.
How long does latanoprost take to work? A measurable pressure drop appears within 4 hours of the first dose, with maximal effect reached by 12 hours. Consistent nightly dosing maintains steady control.
Can latanoprost cause permanent eye-color change? Iris darkening can become permanent after prolonged use, especially in patients with mixed iris colour. Discontinuation halts further change but does not reverse existing pigment.
What should I do if I develop conjunctival redness? Mild redness is common and often resolves spontaneously. If it persists, worsens, or is accompanied by pain, seek ophthalmic assessment promptly.
Is it safe to use latanoprost with contact lenses? Remove soft lenses before instillation and wait at least 15 minutes before reinserting them to avoid drug residue on the lens surface.
Does taking latanoprost with food affect its absorption? No; as an eye drop, systemic absorption is negligible, and meals have no impact on its ocular efficacy.
Are there any foods or supplements I should avoid while using latanoprost? There are no known dietary restrictions. However, inform your ophthalmologist of any herbal products, especially those containing St. John’s wort, which can affect ocular pressure indirectly.
Can latanoprost be used after eye surgery? Although not formally approved, some surgeons prescribe it off-label to prevent postoperative spikes in IOP. This should only be done under specialist guidance.
What information should I provide my doctor when discussing latanoprost?
- Complete list of current medications, including over-the-counter eye drops and supplements.
- History of ocular conditions, surgeries, or infections.
- Any known allergies to eye-drop components.
- Specific visual symptoms you are experiencing (e.g., halos, blurred vision).
Is it possible to buy latanoprost online in Australia? Yes, you can purchase latanoprost through our online pharmacy, which offers both branded and generic options with discreet delivery across the country.

Disclaimer

The information provided about latanoprost is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing latanoprost for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing latanoprost.