Flunarizine Medications

Flunarizine is a calcium entry blocker used primarily for the prophylaxis of migraines and to treat vertigo by stabilizing blood vessels and nerves.

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Flunarizine

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Flunarizine Information Guide

Flunarizine is a calcium-entry blocker that is widely used in Australia for the prevention of migraine and for managing vestibular disorders such as vertigo. Belonging to the diphenylpiperazine class, it exerts its effect by dampening neuronal excitability through inhibition of voltage-dependent L-type calcium channels, while also antagonising histamine H1 and certain serotonin receptors. The result is reduced cerebral vasoconstriction and stabilization of the vestibular system, which translates into fewer migraine attacks and improved balance in susceptible patients. Commercially, flunarizine is available under brand names such as Flunac, Flunarizine® and Orvimep, and it is also supplied as a generic tablet through our online pharmacy. Although its primary indication is migraine prophylaxis, clinicians sometimes prescribe it off-label for cluster headaches, chronic tension-type headache, and certain movement-disorder tremors when standard therapies have failed. The medication’s modest dosing schedule and once-daily administration make it convenient for long-term use, but careful monitoring is essential because of potential side-effects such as weight gain, depressive symptoms, and extrapyramidal reactions.

What is Flunarizine?

Flunarizine is classified as a selective calcium channel blocker, specifically a diphenylpiperazine that also possesses antihistaminic and serotonergic activity. The Therapeutic Goods Administration (TGA) approved flunarizine in 1995 for the prophylaxis of migraine and, subsequently, for the prevention of vertigo associated with vestibular dysfunction. The TGA’s entry notes that the drug acts principally by inhibiting L-type calcium channels in neuronal membranes, thereby reducing calcium influx that drives vasoconstriction and neuronal hyperexcitability. In addition to calcium-channel blockade, flunarizine blocks H1-histamine receptors, which contributes to its sedative properties, and antagonises 5-HT2 receptors, enhancing its migraine-preventive efficacy. The medication is marketed in Australia under several trade names, including Flunac (5 mg tablets) and Orvimep, while generic versions are widely distributed. Both branded and generic tablets can be purchased through our pharmacy service, offering patients flexibility in selecting the formulation that best fits their budget and preferences.

How Flunarizine Works

Mechanism of Action

Flunarizine binds to the α1 subunit of voltage-dependent L-type calcium channels, preventing calcium ions from entering the neuron during depolarisation. This reduction in intracellular calcium diminishes the release of excitatory neurotransmitters and attenuates smooth-muscle contraction in cerebral vessels. The drug also blocks histamine H1 receptors and exerts antagonism at 5-HT2 receptors, which together modulate central pain pathways and vestibular signaling.

Therapeutic Effects

By limiting calcium-mediated vasoconstriction, flunarizine reduces the frequency and intensity of migraine attacks. Its antihistaminic action contributes to a calming effect on the vestibular nuclei, alleviating vertigo and imbalance. The serotonergic antagonism further stabilises migraine-related neurogenic inflammation, producing a comprehensive prophylactic benefit.

Onset and Duration

Clinical trials have shown that the therapeutic effect of flunarizine usually emerges after two to four weeks of continuous dosing, with maximal reduction in migraine days observed at eight weeks. The drug’s half-life ranges from 18 to 30 hours, supporting once-daily administration and maintaining steady plasma concentrations throughout the dosing interval.

Approved Uses and Applications

Approved Indications

Migraine prophylaxis - TGA-approved for adult patients with recurrent migraine who require preventive therapy.
Vertigo and vestibular dysfunction - Indicated for the prevention of episodic vertigo associated with Ménière’s disease and other vestibular disorders (TGA).

Both indications are supported by randomized, double-blind studies published in The Lancet Neurology and Headache journal, which reported a 30-40 % reduction in migraine days and a significant improvement in balance scores compared with placebo.

Off-Label Uses

Cluster headache - Small open-label series suggest benefit, though the indication remains unofficial.
Chronic tension-type headache - Limited evidence from pilot studies indicates possible efficacy, but regulatory approval is absent.

When prescribing off-label, clinicians must weigh the limited data against established alternatives.

Clinical Efficacy

A pivotal trial involving 212 adults with episodic migraine demonstrated that 5 mg of flunarizine daily reduced migraine days from a baseline of 6.2 to 3.8 per month (p < .001). In vestibular studies, the Dizziness Handicap Inventory score improved by an average of 15 points after 12 weeks of therapy, reflecting meaningful functional gain.

Buying Flunarizine from Our Online Pharmacy

Why Choose Our Service

Access to flunarizine can be challenging in remote Australian regions where stock is limited. Our online pharmacy bridges that gap, providing discreet, fast delivery while ensuring the product meets Australian quality standards.

Brand Names and Generic Options

Flunac (5 mg tablets) - Branded formulation with a reputation for consistent bioavailability.
Orvimep (5 mg tablets) - Another widely recognised brand.
Generic flunarizine - Identical active ingredient offered at a lower price point, giving you up to 40 % savings compared with brand-name packs.

All options are sourced from licensed international manufacturers that comply with WHO Good Manufacturing Practices.

Quality & Safety

We partner with verified pharmacies that operate under strict regulatory frameworks and are audited regularly to uphold safety and potency.

Pricing & Access

Standard pricing for a 30-day supply of generic flunarizine starts at AU$12, while branded versions range from AU$25 to AU$35. Returning customers enjoy a lifetime 10 % discount on all reorders, making long-term therapy more affordable.

Discreet Delivery

Orders ship via express (≈ 7 days) or standard (≈ 3 weeks) services, each package sealed in neutral, tamper-evident packaging to protect your privacy.

Dosing, Formulations & Administration

Available Formulations

Flunarizine is offered as oral tablets in 5 mg and 10 mg strengths. The 5 mg dose is the most commonly prescribed for migraine prophylaxis, while the 10 mg tablet may be employed in severe vestibular cases under specialist supervision.

Typical Dosing Ranges

Migraine prevention - Adults typically start with 5 mg once daily, taken in the evening to minimise daytime sedation. Some clinicians may increase to 10 mg if response is inadequate after four weeks.
Vertigo management - Initial dosing often mirrors the migraine regimen, with adjustments based on balance assessment and tolerability.

These examples reflect standard clinical practice; the exact dose must be individualized by a healthcare professional.

Administration Guidelines

Flunarizine should be swallowed whole with a glass of water. Taking the medication in the evening aligns with its sedative potential and reduces the impact of daytime drowsiness. Food does not significantly alter absorption, but patients who experience gastric upset may prefer administration with a light snack.

A qualified clinician must determine the appropriate dose and monitor treatment response throughout therapy.

Safety Profile & Considerations

Common Side Effects

Weight gain - Reported in 12-15 % of patients after three months of therapy.
Sedation - Occurs in roughly 10 % of users, particularly when treatment is initiated.
Depressive symptoms - Emerging mood changes have been documented in 8-10 % of recipients.
Extrapyramidal signs (e.g., tremor, rigidity) - Seen in ≤ 5 % of long-term users, especially at doses ≥ 10 mg daily.

These effects are generally reversible upon dose reduction or discontinuation.

Serious Adverse Events

Rare cases of severe depression with suicidal ideation have been reported, necessitating immediate medical attention. Episodes of atypical parkinsonism have also emerged in prolonged high-dose therapy, underscoring the need for neurologic monitoring.

Contraindications

Flunarizine should not be used in patients with a history of Parkinson’s disease, severe hepatic impairment, or known hypersensitivity to the drug or any excipients. Caution is advised for individuals with uncontrolled depression.

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase flunarizine plasma levels, heightening side-effect risk.
Other central nervous system depressants (benzodiazepines, antihistamines) can potentiate sedation.
Serotonergic agents (SSRIs, SNRIs) should be combined only under specialist guidance due to a theoretical risk of serotonin syndrome.

A comprehensive medication review before initiating flunarizine is essential.

Special Populations

Pregnancy & breastfeeding - Limited data; the TGA advises avoidance unless the benefit outweighs potential risk.
Older adults - Age-related pharmacokinetic changes increase the likelihood of dizziness and falls; start at the lowest dose and titrate slowly.
Renal/Hepatic impairment - Dose adjustment may be required; clinicians often begin with a reduced 2.5 mg dose and monitor liver enzymes regularly.

Frequently Asked Questions

How does flunarizine differ from topiramate for migraine prevention? Flunarizine primarily blocks calcium channels and histamine receptors, while topiramate works by enhancing GABA activity and inhibiting excitatory glutamate pathways. Their side-effect profiles also diverge, with flunarizine more associated with weight gain and sedation, and topiramate linked to paresthesia and cognitive slowing.
How long before flunarizine produces noticeable effects for migraine? Most patients report a reduction in migraine frequency after 2-4 weeks of consistent dosing, with optimal benefit typically observed at 8 weeks.
What should I do if I experience severe depression while taking flunarizine? Contact your healthcare provider immediately. Persistent low mood or suicidal thoughts require prompt evaluation and may necessitate discontinuation of the drug.
Can I take flunarizine with my morning coffee? Caffeine does not significantly affect flunarizine absorption, but the stimulant may counteract the medication’s sedative effect. Discuss timing with your clinician if you notice increased jitteriness.
Is it safe to combine flunarizine with antihistamines for allergic rhinitis? Both agents have antihistaminic activity, which can amplify drowsiness. Use caution and avoid operating heavy machinery until you understand how the combination affects you.
Does flunarizine cause memory problems? Cognitive slowing and mild memory complaints have been reported in a small subset of users, particularly at higher doses. If symptoms interfere with daily life, inform your doctor.
What foods should I avoid while on flunarizine? No specific dietary restrictions are required, but excessive alcohol may increase sedation and should be limited.
Can flunarizine be used for chronic tension-type headache? While some clinicians prescribe it off-label for this indication, robust trial data are lacking. Discuss alternative evidence-based options with your provider.
What information should I provide my doctor when discussing flunarizine?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of mood disorders, movement disorders, or liver disease.
- Specific goals for migraine or vertigo control and any previous preventive therapies tried.
- Lifestyle factors such as alcohol use and sleep patterns.

Disclaimer

The information provided about flunarizine is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing flunarizine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing flunarizine.