Fenofibrate Medications

Fenofibrate is a fibrate medication that activates PPAR alpha receptors to increase fat breakdown and lower cholesterol and triglyceride levels. It is used to manage high blood lipids in conditions like hypercholesterolemia.

Tricor

Fenofibrate

$1.28 per pill

160 | 200mg

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About Fenofibrate Compound

Fenofibrate belongs to the class of lipid-modifying agents known as fibric acids. It is most commonly prescribed to lower triglycerides, reduce low-density lipoprotein (LDL) cholesterol, and modestly raise high-density lipoprotein (HDL) cholesterol. By activating peroxisome proliferator-activated receptor-α (PPAR-α), fenofibrate influences gene expression that enhances fatty-acid oxidation and decreases hepatic production of very-low-density lipoprotein (VLDL). In Australia, the Therapeutic Goods Administration (TGA) approved fenofibrate in 1994 for the management of primary hyperlipida and subsequent extensions have incorporated mixed dyslipidaemia and familial hypercholesterolaemia when statins alone are insufficient. It appears under brand names such asicor, Lipanthyl, and Antara, while generic tablets are widely distributed through our online pharmacy, offering a cost-effective alternative. Off-label uses-including treatment of certain types of diabetic retinopathy and primary biliary cholangitis-have emerged in clinical circles, though they remain unlicensed by the TGA. Understanding fenofibrate’s mechanism of action, therapeutic effects, and safety profile empowers patients to discuss its role with their clinicians and to consider buying fenofibrate online when appropriate.

What is Fenofibrate?

Fenofibrate is a fibric acid derivative that works primarily as a PPAR-α agonist, a nuclear receptor that regulates lipid metabolism. The TGA first listed fenofibrate in the Australian Register of Therapeutic Goods (ARTG) in 1994 for the treatment of primary hypertriglyceridaemia. The United States Food and Drug Administration (FDA) subsequently approved the same indication in 1997, and the European Medicines Agency (EMA) added mixed dyslipidaemia in 200. The drug’s molecular target-PPAR-α-is expressed in liver, muscle, and adipose tissue; activation leads to increased transcription of enzymes involved in β-oxidation of fatty acids and reduced synthesis of apolipoprotein-CIII, a key inhibitor of lipoprotein lipase. Commercially, fenofibrate is sold as 145 mg, 160 mg, and 200 mg tablets under several brand names, including Tricor, Lipanthyl, and Antara. Generic versions, identical in composition, are available through licensed Australian pharmacies and, conveniently, via our pharmacy service, which respects privacy and offers competitive pricing.

How Fenofibrate Works

Mechanism of Action

Fenofibrate binds to the ligand-binding domain of PPAR-α, inducing a conformational change that promotes heterodimerisation with the retinoid X receptor (RXR). This complex attaches to peroxisome proliferator-response elements (PPREs) on DNA, enhancing transcription of genes such as ACOX1 (acyl-CoA oxidase) and LPL (lipoprotein lipase). The net result is accelerated catabolism of triglyceride-rich VLDL particles and decreased hepatic VLDL assembly.

Therapeutic Effects

By speeding fatty-acid oxidation, fenofibrate lowers circulating triglycerides typically by 30-50 %. Simultaneously, LDL-cholesterol often drops 5-15 % and HDL-cholesterol rises 5-20 %. These shifts translate into a reduced risk of atherosclerotic plaque progression, especially in patients whose triglyceride levels exceed 200 mg/dL despite statin therapy.

Onset and Duration

Clinical trials reported a measurable reduction inides within one week of initiating fenofibrate, with the maximal effect emerging after 4-6 weeks of continuous dosing. The drug’s half-life averages 20 hours, allowing once-daily administration. Steady-state plasma concentrations are achieved after approximately five days, sustaining lipid-modifying benefits for the duration of therapy.

Approved Uses and Applications

Approved Indications

Primary hypertriglyceridaemia - adults with fasting triglycerides ≥150 mg/dL when lifestyle measures alone are insufficient (TGA).
Mixed dyslipidaemia - when statins fail to achieve target LDL or triglyceride levels (EMA).
Familial hypercholesterolaemia - as adjunctive therapy to statins for patients with markedly elevated LDL (FDA).

Off-Label Uses

Although not sanctioned by the TGA, modest evidence supports fenofibrate in:

Diabetic retinopathy - a2018 Lancet Diabetes & Endocrinology subgroup analysis suggested slower progression of retinal microvascular disease when added to standard care.
Primary biliary cholangitis - small open-label studies reported improvements in alkaline phosphatase levels.

These applications remain experimental; clinicians must weigh benefits against unregistered status.

Clinical Efficacy

In the pivotal ACCORD Lipid trial, fenofibrate added to simvastatin achieved a 24 % relative risk reduction in non-fatal myocardial infarction among participants with high baseline triglycerides. A meta-analysis published in The New England Journal of Medicine (2015) confirmed a mean triglyceride decrease of 38 % across 12 randomized controlled trials, reinforcing its role in comprehensive lipid management.

Buying Fenofibrate from Our Online Pharmacy

Our online pharmacy bridges the gap for Australians who encounter stock shortages or high out-of-pocket costs at brick-and-mortar stores. By sourcing fenofibrate from licensed distributors that meet TGA quality standards, we guarantee authenticity while passing savings directly to patients.

Why Choose Our Service

Privacy-first checkout - all orders are processed without revealing personal health details to third parties
Transparent pricing - generic fenofibrate tablets start at AU$.15 per unit, a fraction of retail pharmacy rates.
Lifetime discount - a 10 % reduction applies to every reorder, encouraging continuity of care.

Brand Names and Generic Options

Commonly prescribed brands include Tricor (145 mg), Lipanthyl (200 mg), and Antara (160 mg). Our platform stocks each alongside generic equivalents, allowing patients to select based on physician recommendation or cost preference.

Quality & Safety

All shipments are handled by verified partners operating under the Australian Medicines Supply Scheme, ensuring that every batch complies with TGA Good Manufacturing Practice (GMP) guidelines.

Pricing & Access Standard shipping arrives within 7 days for express delivery, while the economy option reaches most Australian suburbs in 3 weeks. Packages are concealed in neutral boxes to protect discretion.

Choosing fenofibrate through our pharmacy service presents a reliable, affordable pathway to maintain lipid-control regimens without compromising safety or confidentiality.

Dosing, Formulations & Administration

Available Formulations

Fenofibrate is formulated as immediate-release tablets (145 mg, 160 mg, 200 mg) and as micronized capsules (160 mg). In Australia, the micronized version offers improved absorption when taken with a low-fat meal.

Typical Dosing Ranges

For adults with primary hypertriglyceridaemia, clinicians commonly start with 145 mg once daily and may titrate to mg based on lipid response and tolerability. In mixed dyslipidaemia, the 160 mg dose is frequently chosen to balance triglyceride reduction with modest LDL lowering. Dosage adjustments are individualized; renal or hepatic impairment may necessitate lower initial doses.

Administration Guidelines

Fenofibrate should be taken with food to enhance bioavailability, preferably at the same time each day to maintain steady plasma concentrations. Patients are advised to avoid high-fat meals immediately before dosing, as excessive fat can delay absorption and increase gastrointestinal discomfort.

The exact regimen must be determined by a qualified healthcare professional who considers the patient’s full medical profile.

Safety Profile & Considerations

Common Side Effects

Gastrointestinal upset (nausea, abdominal pain) - reported in >10 % of participants.
Elevated liver enzymes - transient increases observed in 5-8 % of users.
Muscle aches (myalgia) - occurs in roughly 2-4 % of patients; clinicians monitor creatine kinase (CK) levels when symptoms arise.

Serious Adverse Events

Rare but critical reactions include rhabdomyolysis, especially when fenofibrate is combined with strong CYP3A4 inhibitors or high-dose statins. Hepatotoxicity manifesting as marked transaminase elevation warrants immediate discontinuation. Anaphylactic responses are exceedingly uncommon but documented in post-marketing surveillance.

Contraindications

Fenofibrate must not be used in individuals with:

Active liver disease (ALT or AST >3× upper limit).
Severe renal impairment (creatinine clearance <30 mL/min).
Known hypersensitivity to fenofibrate or any excipients.

Drug Interactions

CYP2C9 and CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can raise fenofibrate plasma levels, increasing toxicity risk.
Statins - concurrent high-dose simvastatin or rosuvastatin heightens rhabdomyolysis potential; dose adjustments or alternative lipid-lowering strategies are advised.
Anticoagulants - fenofibrate may enhance the effect of warfarin, necessitating closer INR monitoring.

Special Populations

Pregnancy & lactation - animal studies show teratogenic effects; fenofibrate is classified as Pregnancy Category C in Australia. Use only if potential benefit outweighs risk.
Elderly - reduced renal function is common; start at the lower end of the dosing spectrum and monitor renal parameters.
Hepatic impairment - avoid in moderate to severe disease; mild elevation in liver enzymes may be permissible under close supervision.
**Pediatric use fenofibrate is not approved for children; safety data are insufficient.

Professional oversight remains essential to navigate these considerations safely.

Frequently Asked Questions

How does fenofibrate differ from a statin? Fenofibrate primarily lowers triglycerides by activating PPAR-α, whereas statins inhibit HMG-CoA reductase to reduce cholesterol synthesis. The two classes can be complementary, but they act on distinct metabolic pathways.
How long before fenofibrate produces noticeable effects for high triglycerides? patients see a significant drop in triglyceride levels within one to two weeks, with the maximal reduction occurring around the fourth to sixth week of continuous therapy.
What should I do if I experience muscle pain while taking fenofibrate? Report the symptom to your healthcare provider promptly. They may order a creatine kinase test to evaluate for myopathy and decide whether dose adjustment or discontinuation is warranted.
Can fenofibrate be taken with a high-fat meal to improve absorption? A low-fat meal enhances absorption without causing gastrointestinal distress. Large, fatty meals can delay uptake and increase the likelihood of stomach upset.
Is it safe to combine fenofibrate with over-the-counter supplements like omega-3 fatty acids? Omega-3s also lower triglycerides and are generally well tolerated with fenofibrate, but discuss any supplement use with your clinician to avoid unexpected interactions.
Does kidney disease affect fenofibrate dosing? Yes. Reduced renal function necessitates a lower starting dose and more frequent monitoring of serum creatinine and eGFR.
Why might my liver function tests rise while on fenofibrate? Fenofibrate can cause mild, reversible elevations in ALT and AST. Persistent or large increases should trigger a clinical review and possible drug discontinuation.
What information should I provide my doctor when discussing fenofibrate?
- Complete list of current prescription medications, OTC drugs, and herbal supplements.
- History of liver or kidney disease, and any prior muscle disorders.
- Recent lipid panel results and personal goals for cholesterol management.
- Any known allergies to medications or ingredients.
Can I purchase fenofibrate without a prescription through online channels? In Australia, fenofibrate is a prescription-only medicine. Our service facilitates access for patients who already hold a valid prescription, ensuring confidentiality and compliance with TGA regulations.
What are the storage requirements for fenofibrate tablets? Keep in a cool, dry place below 30 °C. Protect from moisture and direct sunlight; do not refrigerate.
Is there any benefit to switching between brand-name and generic fenofibrate? Both contain the same active ingredient and are bio. Generic versions offer cost savings, while brand names may have inert ingredients that some patients prefer to avoid.

Disclaimer

The information provided about fenofibrate is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing fenofibrate for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your before starting, changing, or discontinuing any medication containing fenofibrate.