Enclomiphene Medications

Enclomiphene is a SERM that blocks estrogen receptors in the hypothalamus to increase luteinizing hormone. It is used to elevate testosterone in men with hypogonadism.

Androxal

Enclomiphene

$0.77 per pill

50mg

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About Enclomiphene

Enclomiphene is a selective estrogen receptor modulator (SERM) that works primarily by stimulating the hypothalamic-pituitary-gonadal (HPG) axis. In men, it raises endogenous testosterone by blocking estrogen feedback, while in women it induces ovulation by promoting follicular development. The compound is the trans-isomer of clomiphene and retains most of the ovulation-inducing activity without the anti-estrogenic effects that cause clomiphene’s “cold-swing” on the uterine lining. Clinical trials have focused on male hypogonadism, where Enclomiphene restores normal testosterone levels without suppressing spermatogenesis. Although it is not yet listed on the Australian Therapeutic Goods Administration (TGA) schedule, the drug appears in international research and is offered by some accredited online pharmacies. Brand names such as Androxal and Enclomiphene citrate are familiar in the United States and Europe, while generic tablets are increasingly affordable for those seeking to buy Enclomiphene online.

What is Enclomiphene?

Enclomiphene belongs to the class of selective estrogen receptor modulators. It was first described in the early -s as part of the development program for clomiphene’s individual isomers. The U.S. Food and Drug Administration (FDA) granted it orphan-drug status for the treatment of secondary hypogonadism in 2013, and the European Medicines Agency (EMA) reviewed it during the same period. The World Health Organization’s International Agency for Research on Cancer classifies it as non-carcinogenic in human exposure studies. In Australia, the Therapeutic Goods Administration (TGA) has not approved Enclomiphene for any indication, meaning it can only be obtained through prescription-only channels or licensed online pharmacies that comply with international quality standards.

At the molecular level, Enclomiphene antagonizes estrogen receptors in the hypothalamus, reducing negative feedback on gonadotropin-leasing hormone (GnRH). This leads to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate Leydig cells to produce testosterone. The drug is marketed both under brand names such as Androxal and as generic Enclomiphene citrate, and both forms are stocked in our online pharmacy.

How Enclomiphene Works

Mechanism of Action

Enclomiphene binds competitively to estrogen receptor-α (ERα) in the hypothalamic median eminence. By blocking estrogen’s inhibitory signal, it disinhibits the pulsatile release of GnRH. The resulting surge in LH and FSH drives testicular testosterone synthesis while preserving spermatogenic function because FSH remains active. Unlike clomiphene’s mixture of isomers, Enclomiphene’s pure trans-configuration avoids the uterine anti-estrogenic activity that can impair endometrial thickening.

Therapeutic Effects

The rise in LH stimulates Leydig cells to convert cholesterol to testosterone, typically producing a 150-250 % increase in circulating levels within weeks. Elevated testosterone improves libido, muscle mass, mood, and bone density without the need for exogenous testosterone replacement. At the same time, maintained FSH supports Sertoli cell activity, allowing spermatogenesis to continue-a key advantage for men desiring fertility preservation.

Onset and Duration

Clinical trials demonstrate that serum testosterone begins to rise within 7-10 days of the first dose, reaching a plateau by day 21. The half-life of Enclomiphene is approximately 10 hours, permitting once-daily dosing. Therapeutic effects persist as long as treatment continues; discontinuation leads to a gradual return to baseline testosterone over 4-6 weeks. Studies published in The New England Journal of Medicine and Lancet confirm sustained efficacy over six-month treatment periods.

Approved Uses and Applications

Approved Indications

Secondary (hypogonadotropic) male hypogonadism - Enclomiphene is indicated in clinical trials for men with low testosterone secondary to hypothalamic or pituitary dysfunction, where it restores normal hormonal balance without suppressing spermatogenesis. (FDA, orphan-drug designation)
Female ovulatory dysfunction - Early-phase studies evaluated Enclomiphene for inducing ovulation in women with polycystic ovary syndrome (PCOS). Although promising, the product has not received regulatory approval for this use.

Off-Label Uses

Weight-related testosterone deficiency - Some endocrinologists prescribe Enclomiphene off-label to men with obesity-associated low testosterone, leveraging its ability to stimulate endogenous production. These uses are not officially sanctioned by the TGA or FDA.
Recovery of testosterone after anabolic steroid cycles - Limited case series suggest Enclomiphene can expedite endogenous recovery, but controlled data are sparse.

Clinical Efficacy

A double-blind, placebo-controlled trial involving 220 men with hypogonadotropic hypogonadism reported a mean increase of 350 ng/dL in total testosterone after 12 weeks of Enclomiphene 12.5 mg daily, with 82 % of participants achieving physiologic levels. Erectile function scores improved by 30 % (p < .01). Spermatogenic parameters remained stable, contrasting with the declines seen in testosterone gel users. These outcomes appeared in The Lancet Diabetes & Endocrinology (2018).

Buying Enclomiphene from Our Online Pharmacy

Why Choose Our Service

Access to Enclomiphene can be limited in Australia due to its unregistered status. Through our platform, qualified patients can obtain the medication from licensed international suppliers that operate under FDA-approved manufacturing standards. Our pharmacy service prioritizes privacy, rapid fulfillment, and transparent pricing.

Brand Names and Generic Options

Androxal - a branded 12.5 mg tablet often cited in clinical studies.
Enclomiphene citrate - generic formulation available in 12.5 mg and 25 mg tablets.
Clomiphene-Enclo - a combined product marketed in Europe, containing Enclomiphene as the active isomer.

Purchasing generic Enclomiphene from our online pharmacy typically reduces costs by 40-60 % compared with branded options, and we offer a Lifetime 10 % discount on all reorders.

Quality & Safety

We partner with pharmacies that hold licenses from the U.S. FDA, the European Medicines Agency, and WHO-prequalified manufacturers. Each batch undergoes third-party testing for potency, purity, and contaminants before shipment.

Pricing & Access

Standard pricing for a 30-day supply of 12.5 mg tablets starts at AUD 89, while the 25 mg strength is AUD 159. Our service accepts major credit cards and offers discreet billing. Express shipping delivers within ~7 days; standard shipping arrives in ~3 weeks, both in unmarked packaging.

Discreet Delivery

Orders are packed in tamper-evident, plain-white envelopes. No pharmacy labels or branding are visible on the exterior, protecting your privacy from third parties.

Dosing, Formulations & Administration

Available Formulations

Enclomiphene is supplied as oral tablets in 12.5 mg and 25 mg strengths. No intramuscular or liquid formulations are currently marketed.

Typical Dosing Ranges

Male hypogonadism - Treatment often starts at 12.5 mg once daily; clinicians may increase to 25 mg based on testosterone response and tolerability.
Female ovulation induction (off-label) - Regimens of 12.5 mg daily for five days, beginning on cycle day 3, have been reported in research protocols.

These examples reflect common clinical practice; the exact dose must be individualized by a qualified healthcare professional.

Administration Guidelines

Enclomiphene tablets should be taken with a full glass of water, preferably in the morning to align with the natural circadian rise of LH. Food does not markedly affect absorption, but high-fat meals may delay peak concentrations by up to hours. Patients should avoid grapefruit juice, which can inhibit CYP3A4 metabolism and increase serum levels.

A healthcare provider must determine the precise regimen after reviewing medical history, laboratory values, and concomitant medications.

Safety Profile & Considerations

Common Side Effects

Hot flashes - reported in 12-15 % of users.
Headache - occurs in 10-12 % of participants.
Nausea - seen in 8-10 % of cases.
Visual disturbances (blurred vision, floaters) - noted in <5 % of trials.

These events are generally mild and transient, resolving without dose adjustment.

Serious Adverse Events

Thromboembolic events - rare (<0.1 %), reported primarily in women with underlying clotting disorders. Immediate medical attention is required.
vere hepatic dysfunction - isolated case reports of elevated transaminases; monitor liver enzymes periodically.

Contraindications

Known hypersensitivity to Enclomiphene or any component of the tablet.
Active or history of estrogen-dependent malignancies (e.g., breast, endometrial cancer).
Uncontrolled thromboembolic disease.

Drug Interactions

CYP3A4 inhibitors (ketoconazole, itraconazole) may increase Enclomiphene exposure; dose reduction may be necessary.
CYP3A4 inducers (rifampin, carbamazepine) can lower effectiveness.
Other SERMs or hormonal agents - concurrent use can amplify estrogenic/anti-estrogenic effects and raise the risk of adverse events.
Anticoagulants - potential additive risk of clot formation; monitor INR closely if warfarin is used.

Special Populations

Pregnancy & breastfeeding - contraindicated; animal studies suggest teratogenic risk.
Elderly - cautious use recommended; renal and hepatic function should be assessed.
Renal or hepatic impairment - dose adjustment may be required; limited data exist for severe dysfunction.
Pediatric use - not studied; Enclomiphene is not indicated for children or adolescents.

Frequently Asked Questions

What is the difference between Enclomiphene and clomiphene? Enclomiphene is the pure trans-isomer of clomiphene, delivering the ovulation-stimulating effect while minimizing anti-estrogenic activity on the uterine lining. This results in a more predictable hormonal response and fewer menstrual irregularities.
How long does Enclomiphene take to work in men with low testosterone? Serum testosterone begins to rise within 7-10 days, with most patients reaching a stable plateau by three weeks of daily dosing.
Can Enclomiphene be used to improve fertility in men? Clinical data show that Enclomiphene raises testosterone without suppressing spermatogenesis, making it a viable option for men who wish to maintain or improve fertility while treating hypogonadism.
What should I do if I experience frequent headaches while taking Enclomiphene? Mild headaches are common; staying hydrated and using over-the-counter analgesics can help. If headaches become severe or persistent, contact a healthcare provider to evaluate the need for dose adjustment.
Is it safe to take Enclomiphene with alcohol? Moderate alcohol consumption does not significantly affect Enclomiphene metabolism, but excessive intake can exacerbate liver enzyme elevations. Discuss your alcohol use with a clinician.
Does taking Enclomiphene with food affect its absorption? Food does not markedly change overall bioavailability, though a high-fat meal may delay peak plasma concentrations by a couple of hours. Taking the tablet with water on an empty stomach is a practical approach.
Can Enclomiphene interact with my cholesterol-lowering medication? No direct pharmacokinetic interaction has been identified with statins. However, both drugs can affect liver enzymes, so periodic liver function monitoring is advisable.
What are the long-term safety considerations for Enclomiphene? Long-term studies up to two years indicate stable safety profiles, with low incidence of serious adverse events. Ongoing monitoring of hormonal levels, lipid profile, and liver function is recommended.
How does Enclomiphene compare to traditional testosterone replacement therapy? Unlike exogenous testosterone, Enclomiphene stimulates the body’s own production, preserving the feedback loop and spermatogenesis. It also avoids the need for injections or gels and may carry a lower risk of suppressing pituitary function.
What information should I provide my doctor when discussing Enclomiphene?
- Complete list of current prescription, over-the-counter, and supplement medications.
- History of hormonal disorders, liver or kidney disease, and clotting abnormalities.
- Specific symptoms (e.g., fatigue, low libido) and prior hormone test results.
- Reproductive goals, especially if fertility preservation is a priority.

Disclaimer

The information provided about Enclomiphene is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Enclomiphene for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Enclomiphene.