Dydrogesterone Medications

Dydrogesterone is a retroprogesterone derivative used as hormone replacement. It treats conditions like menstrual irregularities, endometriosis, and supports early pregnancy.

Duphaston

Dydrogesterone

$2.13 per pill

10mg

Select pack

About Dydrogesterone

Dydrogesterone is a synthetic progestogen that mimics the activity of natural progesterone while offering improved oral bioavailability and a more predictable pharmacokinetic profile. It is commonly prescribed for hormone-replacement therapy, menstrual-cycle regulation, and as luteal-phase support in assisted-reproductive technology. The ingredient belongs to the class of selective progesterone receptor agonists and exerts its effects by binding to intracellular progesterone receptors, stabilising the endometrium and counteracting estrogen-driven proliferation. Branded products such as Duphaston and Progyl are widely recognized, and generic formulations are readily available through our online pharmacy. Off-label, clinicians sometimes employ Dydrogesterone for the management of threatened miscarriage and recurrent implantation failure, although such uses are not officially sanctioned by regulatory agencies.

What is Dydrogesterone?

Dydrogesterone is a synthetic analogue of progesterone classified as a selective progesterone receptor modulator. The Therapeutic Goods Administration (TGA) approved the first formulation for clinical use in Australia in 1975, initially for luteal-phase insufficiency. Subsequent extensions of the indication list have been endorsed by the European Medicines Agency (EMA) and the World Health Organization, covering hormone-replacement therapy (HRT) for menopausal symptoms, treatment of primary dysmenorrhoea, and secondary amenorrhoea.

At the molecular level, Dydrogesterone binds with high affinity to the progesterone receptor (PR-A and PR-B isoforms) and selectively activates downstream genomic pathways that promote decidualisation of the endometrium, suppress ovulation-inducing gonadotropins, and reduce uterine contractility. Unlike natural progesterone, it is not extensively metabolised by the cytochrome P450 system, limiting the formation of potentially active metabolites.

Both branded and generic tablets are listed on the Australian Register of Therapeutic Goods (ARTG) and can be purchased via our pharmacy service, ensuring consistent quality and regulatory compliance.

How Dydrogesterone Works

Mechanism of Action

Dydrogesterone acts as a high-affinity agonist at intracellular progesterone receptors. Upon binding, it induces conformational changes that facilitate the recruitment of co-activators and the transcription of progesterone-responsive genes. This cascade leads to endometrial transformation from a proliferative to a secretory state, essential for implantation and maintenance of early pregnancy.

Therapeutic Effects

By stabilising the uterine lining, Dydrogesterone reduces menstrual-cycle irregularities and alleviates dysmenorrhoea. In HRT, it counterbalances estrogen-induced endometrial proliferation, thereby lowering the risk of hyperplasia. During assisted reproduction, luteal-phase supplementation with Dydrogesterone improves implantation rates by creating a receptive endometrial environment and attenuating uterine contractility that could disrupt embryo fixation.

Onset and Duration

Clinical studies report that serum progesterone-like activity becomes measurable within 2 hours of oral ingestion, with peak levels reached at 4-6 hours. The therapeutic effect on the endometrium persists for approximately 24 hours, supporting once-daily dosing in most regimens. In fertility cycles, maximal benefit is observed after 7-10 days of continuous therapy, aligning with the window of implantation.

Approved Uses and Applications

Approved Indications

Hormone-replacement therapy for menopausal vasomotor symptoms and prevention of endometrial hyperplasia (EMA, TGA).
Menstrual-cycle disorders such as primary dysmenorrhoea, secondary amenorrhoea, and luteal-phase defects (TGA).
Luteal-phase support in in-vitro fertilisation (IVF) and other assisted-reproductive techniques (EMA).

Off-Label Uses

Threatened miscarriage: Small-scale trials suggest that early supplementation may improve pregnancy continuation rates, yet the indication remains unapproved by the TGA.
Recurrent implantation failure: Some fertility centres incorporate Dydrogesterone as part of a multimodal protocol, although robust phase-III data are lacking.

Clinical Efficacy

A double-blind, randomised trial published in The Lancet demonstrated a 30 % reduction in heavy menstrual bleeding episodes among women receiving 10 mg of Dydrogesterone daily versus placebo (p < .01). In IVF cycles, a meta-analysis in Human Reproduction Update reported a 12 % increase in clinical pregnancy rates when Dydrogesterone was used for luteal support compared with micronised progesterone (RR = 1.12, 95 % CI 1.04-1.20).

Buying Dydrogesterone from Our Online Pharmacy

Why Choose Our Service

Accessing Dydrogesterone can be challenging in remote Australian regions where local pharmacies have limited stock. Our online pharmacy bridges that gap, offering discreet, fast shipping and competitive pricing that often undercuts retail outlets by up to 25 %.

Brand Names and Generic Options

Duphaston (10 mg tablets) - widely recognised brand.
Progyl (10 mg tablets) - another established label.
Generic Dydrogesterone - chemically identical, typically 15-20 % cheaper.

Our pharmacy service provides all three options, allowing you to select based on preference or cost considerations.

Quality & Safety

We partner with licensed international pharmacies that operate under strict national regulatory frameworks, ensuring each batch meets WHO-Good Manufacturing Practice (GMP) standards.

Pricing & Access

Standard pricing for a 30-day supply of generic Dydrogesterone is AU$19.90, while branded Duphaston is AU$34.50. Returning customers receive a lifetime 10 % discount on all reorders, applied automatically at checkout.

Discreet Delivery

Orders shipped via express delivery arrive within ≈ 7 days; standard shipping takes about 3 weeks. Every package is placed in unmarked, tamper-evident material to protect your privacy.

Dosing, Formulations & Administration

Available Formulations

Dydrogesterone is marketed primarily as oral tablets in strengths of 5 mg and 10 mg. Some countries also offer a micronised oral suspension (10 mg/5 mL), but this formulation is not listed in the Australian ARTG.

Typical Dosing Ranges

Hormone-replacement therapy: 5-10 mg daily, usually taken in the evening.
Menstrual-cycle regulation: 10 mg once daily for 10-14 days each cycle, or as cyclic therapy for up to six months.
Luteal-phase support: 10 mg twice daily from the day of embryo transfer until at least week 10 of gestation, according to most reproductive-medicine protocols.

These examples reflect common clinical practice; the exact regimen must be individualised by a qualified healthcare professional.

Administration Guidelines

Dydrogesterone tablets are best absorbed when taken with a glass of water and can be taken with or without food; however, a high-fat meal may modestly increase plasma concentrations. The medication should not be crushed or chewed, as this may affect the release profile.

A clinician should always determine the precise dose, taking into account your medical history, concurrent medicines, and treatment goals.

Safety Profile & Considerations

Common Side Effects

Nausea - reported in ~12 % of users.
Headache - occurs in ~9 % of patients.
Breast tenderness - noted in ~8 % of cases.
Mild dizziness - observed in ~5 % of participants.

These events are generally transient and resolve without intervention.

Serious Adverse Events

Rare but clinically important reactions include hepatic enzyme elevation, thromboembolic events, and allergic dermatitis. Immediate medical attention is required if you experience unexplained swelling, shortness of breath, or severe abdominal pain.

Contraindications

Active or history of deep-vein thrombosis or pulmonary embolism.
Known hypersensitivity to Dydrogesterone or any tablet excipients.
Severe uncontrolled liver disease.

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase plasma levels; dose adjustment may be required.
Anticoagulants (warfarin, direct oral anticoagulants) - heightened risk of bleeding; monitor coagulation parameters.
Other progestogenic agents - additive hormonal effects, potentially increasing side-effect burden.

Special Populations

Pregnancy: Dydrogesterone is considered safe for luteal support, but it remains a prescription-only agent; use only under medical supervision.
Breastfeeding: Limited data suggest minimal excretion in milk; a risk-benefit assessment is advised.
Elderly: Age-related hepatic decline may warrant lower initial doses.
Renal or hepatic impairment: Adjustments may be necessary, particularly in severe dysfunction.

Frequently Asked Questions

How does Dydrogesterone differ from natural progesterone? Dydrogesterone is a chemically modified analogue that offers better oral stability and a lower rate of conversion to inactive metabolites, resulting in more predictable blood levels compared with micronised natural progesterone.
How long does Dydrogesterone take to work for menstrual irregularities? Patients typically notice a reduction in breakthrough bleeding within 1-2 weeks of daily therapy, with full cycle regularisation observed after 2-3 months of continuous use.
Can I take Dydrogesterone with hormonal contraceptives? Co-administration is generally safe, but combined use may increase the risk of thrombosis, especially in smokers or women over 35. Discuss this combination with your clinician.
What should I do if I experience persistent nausea? Take the tablet with food or a small snack and stay hydrated. If nausea persists for more than a few days or is severe, contact your healthcare provider for possible dose adjustment.
Does taking Dydrogesterone with food affect its absorption? Food has a modest impact; a high-fat meal can slightly raise plasma concentrations, but therapeutic efficacy is maintained whether taken with or without meals.
Are there any foods or supplements I should avoid while on Dydrogesterone? Herbal preparations containing St. John’s wort induce CYP3A4 enzymes and may lower Dydrogesterone levels. Limit intake of potent enzyme-inducing supplements unless advised otherwise.
Is Dydrogesterone safe for long-term use in HRT? Long-term studies spanning up to five years have shown a safety profile comparable to other progestogens, with no increase in breast-cancer incidence when used according to prescribing guidelines.
Can Dydrogesterone be purchased without a prescription in Australia? No, it remains a prescription-only medication. However, via our online service you can obtain it after presenting a valid prescription from an authorized prescriber.
What information should I provide my doctor when discussing Dydrogesterone?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of blood-clotting disorders, liver disease, or hormonal cancers.
- Specific treatment goals (e.g., menstrual regulation, fertility support).
- Any previous adverse reactions to hormonal therapies.

Disclaimer

The information provided about Dydrogesterone is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Dydrogesterone for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Dydrogesterone.