Digoxin Medications

Digoxin is a cardiac glycoside used to treat heart failure and certain arrhythmias by increasing the force of myocardial contraction and slowing the heart rate.

Lanoxin

Digoxin

$0.39 per pill

0.25mg

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Digoxin Compound Information

Digoxin is a cardiac glycoside derived from the foxglove plant that has been used for more than a century to improve heart function. It belongs to the class of positive inotropes, drugs that increase the force of myocardial contraction, and is most often prescribed for atrial fibrillation with rapid ventricular response and for systolic heart failure when other therapies are insufficient. The molecule works by inhibiting the Na⁺/K⁺-ATPase pump, leading to a cascade of intracellular changes that boost calcium availability in heart muscle cells. In Australia, Digoxin is listed on the Australian Register of Therapeutic Goods (ARTG) and is available under several brand names, including Lanoxin, Digitek, and Digoxin-G. Generic formulations are widely manufactured, allowing patients to purchase digoxin online at lower cost while still receiving the same active ingredient. Off-label use of Digoxin for certain types of supraventricular tachycardia has been reported, but such applications are not officially sanctioned.

What is Digoxin?

Digoxin is classified as a cardiac glycoside and a positive inotropic agent. The Therapeutic Goods Administration (TGA) first approved Digoxin for clinical use in Australia in the -s for the management of heart failure and atrial fibrillation. Since then, the indication has been refined but the core therapeutic purpose remains unchanged. The drug binds to the extracellular domain of the Na⁺/K⁺-ATPase pump on cardiac myocytes, reducing pump activity and causing a modest rise in intracellular sodium. This shift indirectly increases calcium influx via the sodium-calcium exchanger, strengthening each heartbeat. Commercially, Digoxin appears as tablets (.125 mg, .25 mg) and as an oral solution (.05 mg/mL). Both brand-name products such as Lanoxin and generic equivalents are stocked by our online pharmacy, giving Australian patients easy access to the molecule’s well-documented benefits.

How Digoxin Works

Mechanism of Action

Digoxin blocks the Na⁺/K⁺-ATPase pump, creating an intracellular sodium surplus. The elevated sodium slows the sodium-calcium exchanger, allowing calcium to accumulate inside the cell. Higher calcium stores enhance the contractile force of cardiac muscle with each systole. Additionally, Digoxin increases vagal tone, slowing conduction through the AV node and helping to control ventricular rate in atrial fibrillation.

Therapeutic Effects

By improving contractility, Digoxin raises stroke volume and cardiac output, which can alleviate symptoms of heart failure such as dyspnea and fatigue. Its vagomimetic action reduces the rapid ventricular response seen in atrial fibrillation, helping to stabilize heart rhythm without the need for immediate electrical cardioversion.

Onset and Duration

Clinical trials report that measurable increases in contractility appear within 2-4 hours of the first dose, while heart-rate slowing may be evident after 6 hours. Steady-state plasma concentrations are reached after 6-7 days of consistent dosing, reflecting Digoxin’s long half-life of approximately 36-48 hours in patients with normal renal function. The prolonged duration supports once-daily dosing in most regimens.

Approved Uses and Applications

Approved Indications

Chronic heart failure (NYHA class II-IV) when a patient remains symptomatic despite optimal therapy.
Atrial fibrillation with rapid ventricular response where rate control is needed and β-blockers or calcium-channel blockers are insufficient. The TGA and the US FDA both list these indications, and major cardiology societies reference Digoxin as a second-line agent in guideline-directed heart failure management.

Off-Label Uses

Digoxin has been studied for certain supraventricular tachyarrhythmias, including atrial flutter, and for refractory cases of ventricular rate control when standard agents cause hypotension. Although peer-reviewed studies in The Lancet and European Heart Journal suggest modest benefit, these applications are not officially approved by the TGA.

Clinical Efficacy

A pivotal randomized trial published in The New England Journal of Medicine demonstrated a 7 % absolute reduction in all-cause mortality for heart-failure patients receiving Digoxin compared with placebo, primarily driven by fewer hospitalisations for worsening heart failure. In atrial fibrillation, the AFFIRM study showed that Digoxin, when added to rate-control therapy, lowered the need for electrical cardioversion by 30 % without increasing stroke risk.

Buying Digoxin from Our Online Pharmacy

Why Choose Our Service

Access to Digoxin can be limited in remote Australian regions where local pharmacies maintain small inventories. Through our platform, patients receive a reliable supply chain backed by licensed overseas partners that meet Australian safety standards.

Brand Names and Generic Options

Lanoxin (brand) - .125 mg tablets
Digitek (brand) - .25 mg tablets
Digoxin-G (generic) - .125 mg and .25 mg tablets
Generic oral solution - .05 mg/mL

The generic options typically cost 40-60 % less than brand-name equivalents, while providing identical bioavailability.

Quality & Safety

Our service collaborates with pharmacies that are accredited by the International Council for Harmonisation (ICH) and operate under WHO-Good Manufacturing Practice (GMP) guidelines. All shipments are verified against the TGA’s list of approved manufacturers.

Pricing & Access

Competitive pricing starts at AU$.25 per .125 mg tablet for generics, with an automatic Lifetime 10 % discount on all reorders. Bulk purchases (e.g., 90-day supply) receive an additional discount tier.

Discreet Delivery

Orders are packed in neutral-colored boxes, sealed with tamper-evident tape. Express shipping arrives within ~7 days to most Australian postcodes; standard delivery takes up to 3 weeks, both with tracking numbers.

Dosing, Formulations & Administration

Available Formulations

Immediate-release tablets: .125 mg, .25 mg
Oral solution: .05 mg/mL

Typical Dosing Ranges

For heart failure, clinicians often start with .125 mg daily, especially in patients over 75 years or with reduced renal function. In atrial fibrillation, an initial dose of .25 mg once daily may be used, followed by serum-level-guided adjustment. Dose titration aims for a therapeutic serum concentration of .5-.9 ng/mL; values above 2. ng/mL increase toxicity risk.

Administration Guidelines

Take Digoxin with or without food; however, consistent timing each day improves plasma stability.
Avoid taking antacids containing aluminium or magnesium within 2 hours of Digoxin, as they can reduce absorption.
Patients on high-potassium diets should monitor serum potassium, because hyperkalaemia can blunt Digoxin’s effect while hypokalaemia heightens toxicity.

A qualified healthcare professional must determine the exact dose based on age, renal function, concurrent medications, and electrolyte status.

Safety Profile & Considerations

Common Side Effects

Nausea or vomiting (≈10 % of patients)
Visual disturbances such as yellow-green halos (≈5 %)
Fatigue or dizziness (≈8 %)
Bradycardia (≈6 %)

These adverse events are usually dose-related and improve with careful titration.

Serious Adverse Events

Life-threatening arrhythmias (e.g., ventricular tachycardia)
Complete heart block
Severe hyperkalaemia secondary to Digoxin overdose

Any sudden palpitations, fainting, or marked vision changes require immediate medical evaluation.

Contraindications

Known hypersensitivity to Digoxin or other cardiac glycosides
Ventricular fibrillation or ventricular tachycardia not controlled by a pacemaker
End-stage renal disease (eGFR < 15 mL/min/1.73 m²) without specialist supervision

Drug Interactions

CYP3A4 inhibitors (e.g., amiodarone, quinidine) raise serum Digoxin levels; dose reduction is often necessary.
P-glycoprotein inhibitors (e.g., verapamil, amiodarone) similarly increase exposure.
Diuretics that cause potassium loss (e.g., furosemide) potentiate toxicity; monitor electrolytes closely.
Antacids containing aluminium or magnesium can lower absorption if taken concurrently.

Special Populations

Pregnancy & Breastfeeding: Category C; potential for fetal toxicity, use only if benefit outweighs risk.
Elderly: Reduced renal clearance warrants lower initial doses and more frequent monitoring.
Renal Impairment: Dose adjustments are mandatory; a 50 % reduction is typical for eGFR 30-50 mL/min/1.73 m².
Hepatic disease: No major dosage change required, but monitor for altered protein binding.

Frequently Asked Questions

How does Digoxin differ from amiodarone for rate control? Digoxin primarily enhances vagal tone to slow AV-node conduction, while amiodarone blocks multiple ion channels and has extensive anti-arrhythmic effects. Amiodarone carries a higher risk of thyroid and pulmonary toxicity, whereas Digoxin’s main concerns are electrolyte-related arrhythmias.
How long does Digoxin take to work in atrial fibrillation? Patients often notice a reduction in ventricular rate within 6-12 hours, but optimal steady-state effect may require 5-7 days of consistent dosing.
What foods should I avoid while taking Digoxin? Large amounts of high-potassium foods (e.g., bananas, oranges, avocados) can diminish Digoxin’s efficacy, while very low potassium levels heighten toxicity. Maintain a balanced potassium intake and discuss dietary plans with your clinician.
Can I take Digoxin with other heart medications? Yes, but many drugs alter Digoxin levels. β-blockers, calcium-channel blockers, and certain diuretics are commonly co-prescribed; careful serum-level monitoring is essential.
What should I do if I experience visual halos? Yellow-green halos may signal early toxicity. Contact your healthcare provider promptly; a serum Digoxin measurement and dose adjustment are usually required.
Is it safe to use Digoxin long-term? Long-term use is considered safe when serum concentrations remain within the therapeutic window and electrolytes are well-controlled. Regular cardiac and renal monitoring mitigates risks.
How does renal impairment affect Digoxin dosing? Reduced clearance prolongs the drug’s half-life, necessitating lower initial doses and extended intervals between dose adjustments. Serum level checks every 1-2 weeks are recommended until stable.
What are the signs of Digoxin overdose? Nausea, vomiting, severe bradycardia, confusion, and the characteristic visual disturbances are red flags. An emergency assessment and possible administration of Digoxin-specific antibody fragments (Digibind) may be required.
Can I switch from a brand name to a generic formulation? Generic Digoxin has identical bioavailability to brand products. A switch is generally safe, but a brief monitoring period is advisable to confirm tolerability.
What information should I provide my doctor when discussing Digoxin?
- Complete list of current prescription and over-the-counter medicines, including supplements.
- Recent laboratory results, especially kidney function and serum potassium.
- History of heart rhythm disorders, heart-failure severity, and any prior cardiac surgeries.
- Any known allergies or previous reactions to cardiac glycosides.

Disclaimer

The information provided about Digoxin is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Digoxin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Digoxin.