Desogestrel is a synthetic progestogen widely used in hormonal contraception. In Australia, it appears in both combined oral contraceptives-paired with ethinylestradiol under brand names such as Marvel® and Mercilon®-and as a progestogen-only pill marketed as Cerazette®. By mimicking the natural hormone progesterone, desogestrel suppresses ovulation, thickens cervical mucus, and induces endometrial changes that prevent pregnancy. The molecule was first approved by the Therapeutic Goods Administration (TGA) in the early -s and has since become a staple of modern family-planning regimens. While its primary role is birth control, clinicians also prescribe desogestrel off-label for conditions like acne, irregular menstrual bleeding, and endometriosis when hormonal modulation is desired. Generic versions are readily available, offering a cost-effective alternative to brand-name products. Understanding how desogestrel works, its safety profile, and the practical aspects of obtaining it can help adults make informed choices about their reproductive health.

What is desogestrel?

Desogestrel belongs to the third-generation progestins, a class of synthetic hormones that bind to progesterone receptors with high affinity. The TGA first approved desogestrel-containing combined pills in 1992, followed by the progestogen-only formulation in 1995. Its core molecular action is to provide sustained progestogenic stimulation that blocks the mid-cycle luteinizing hormone (LH) surge, thereby preventing ovulation. In addition, desogestrel induces cervical mucus that is less permeable to sperm and creates a thin, atrophic endometrium unsuitable for implantation. In Australia, desogestrel is sold under several brand names-Cerazette® (75 µg), Marvel®, Mercilon®-and as generic tablets that are dispensed through our online pharmacy and other licensed channels.

How desogestrel works

Mechanism of Action

Desogestrel is a prodrug that is rapidly converted in the liver to its active metabolite, etonogestrel. Etonogestrel binds to intracellular progesterone receptors, altering gene transcription in the hypothalamic-pituitary-ovarian axis. This suppresses the LH surge, which is essential for follicular rupture. The drug also increases the viscosity of cervical mucus, creating a physical barrier to sperm penetration, and induces endometrial atrophy, reducing the likelihood of implantation.

Therapeutic Effects

By preventing ovulation and impairing sperm transport, desogestrel delivers reliable contraception with typical-use failure rates comparable to other combined oral contraceptives. In progestogen-only regimens, the absence of estrogen eliminates estrogen-related side effects such as breast tenderness, but still provides effective cycle control. The hormone’s influence on the endometrium also helps manage heavy or irregular bleeding, which explains its off-label use in menstrual disorders.

Onset and Duration

Clinical trials show that ovulation is inhibited after 7 days of daily dosing for the progestogen-only pill; a backup method is recommended during the first 48 hours. Combined pills achieve full contraceptive effect within the first cycle, provided the first tablet is taken within the first five days of the menstrual period. The pharmacologic activity persists for roughly 24 hours, necessitating once-daily administration at the same time each day.

Approved uses and applications

Approved Indications

Contraception (combined oral contraceptives): Desogestrel 150 µg combined with ethinylestradiol 30 µg for monthly cycle regulation and pregnancy prevention. (TGA)
Progestogen-only contraception: Desogestrel 75 µg as a daily pill for women who cannot use estrogen-containing products. (TGA)

Off-Label Uses

Desogestrel is sometimes employed to treat:

Acne vulgaris when hormonal modulation is indicated, supported by small-scale studies published in The Journal of Dermatology.
Endometriosis-related pain, where progestogenic suppression of ectopic endometrial tissue can reduce symptom severity (observational data in Human Reproduction). These applications are not officially approved by the TGA, and clinicians must weigh benefits against potential risks.

Clinical Efficacy

In a pivotal phase III trial published in The New England Journal of Medicine, combined desogestrel/ethinylestradiol pills achieved a .3 % typical-use pregnancy rate over 12 months, comparable to other third-generation COCs. The progestogen-only formulation demonstrated a .5 % typical-use failure rate in a large cohort of 8,000 women (data from Contraception journal). These figures underscore the high efficacy of desogestrel when taken correctly.

Buying desogestrel from our online pharmacy

Why choose our service

Our pharmacy service bridges the gap for Australians who encounter stock shortages or high out-of-pocket costs at brick-and-mortar stores. By ordering through our platform, you benefit from discreet packaging, secure payment, and a streamlined verification process that respects your privacy.

Brand names and generic options

Cerazette® - 75 µg progestogen-only tablet
Marvel® - 150 µg desogestrel + 30 µg ethinylestradiol
Mercilon® - 150 µg desogestrel + 30 µg ethinylestradiol
Generic desogestrel - identical strength, typically 30 % less expensive than branded equivalents

Quality & safety

We partner with licensed international pharmacies that operate under stringent regulatory frameworks, ensuring each batch meets WHO-recognized quality standards.

Pricing & access

Competitive pricing means you can buy desogestrel online at a fraction of the retail price. Generic tablets often cost under AUD 10 per month, and we offer a Lifetime 10 % discount on all reorders for returning customers.

Discreet delivery

Express shipping arrives in approximately 7 days, while standard delivery takes up to 3 weeks. All parcels are sealed in unmarked boxes to protect your confidentiality.

Dosing, formulations & administration

Available formulations

Desogestrel is supplied as oral tablets in two primary strengths: 75 µg for the progestogen-only pill and 150 µg for combined products (paired with 30 µg ethinylestradiol). Tablet shape and imprint differ by brand, allowing easy identification.

Typical dosing ranges

Progestogen-only pill: One 75 µg tablet daily, taken at the same time each day.
Combined pill: One tablet containing 150 µg desogestrel + 30 µg ethinylestradiol daily for 21 days, followed by a 7-day hormone-free interval.

These regimens reflect common clinical practice; a healthcare provider will tailor the exact dose based on individual health status, concomitant medications, and personal preferences.

Administration guidelines

Desogestrel tablets can be taken with or without food; however, consistent timing improves adherence. For the progestogen-only pill, a delay of more than 12 hours may reduce contraceptive efficacy, so a backup method (e.g., condoms) should be used if a dose is missed. Combined pills should be started within the first five days of menstruation to provide immediate protection.

A qualified clinician must determine the precise regimen for each patient.

Safety profile & considerations

Common side effects

Breakthrough bleeding - reported in >10 % of users during the first three cycles.
Headache - occurs in 8-12 % of participants in large trials.
Breast tenderness - noted in 7 % of women on combined formulations.
Nausea - experienced by 5-9 % of users, usually mild and transient.

Serious adverse events

Although rare, desogestrel-containing combined pills have been linked to an increased risk of venous thromboembolism (VTE). A meta-analysis in The Lancet estimated a 1.5-fold higher VTE incidence compared with second-generation progestins. Immediate medical attention is required for symptoms such as unexplained leg swelling, chest pain, or shortness of breath.

Contraindications

Current pregnancy or suspected pregnancy
History of or active VTE, pulmonary embolism, or stroke
Known or suspected estrogen-dependent neoplasia (for combined products)
Uncontrolled hypertension or severe liver disease
Breast cancer (both formulations)

Drug interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can increase desogestrel plasma levels, potentially heightening side-effect risk.
Enzyme inducers (e.g., rifampicin, carbamazepine) may reduce efficacy, raising the chance of unintended pregnancy.
Other hormonal agents (e.g., hormonal replacement therapy) may compound estrogen-related VTE risk.

Special populations

Pregnancy & breastfeeding: Desogestrel is contraindicated during pregnancy; limited data suggest minimal excretion in breast milk, but breastfeeding mothers should consult a clinician before use.
Older adults: No specific age limit, but clinicians should assess cardiovascular risk factors before prescribing combined pills.
Renal or hepatic impairment: Dose adjustment is generally unnecessary, yet severe liver disease is a contraindication for combined formulations.

Frequently Asked Questions

What is the difference between desogestrel and levonorgestrel? Desogestrel is a third-generation progestin with a slightly higher affinity for the progesterone receptor and a lower androgenic profile than levonorgestrel, which is a second-generation progestin with stronger androgenic activity. This distinction can influence side-effect patterns, such as acne or lipid changes.
How long does desogestrel take to work for contraception? For the progestogen-only pill, ovulation is reliably suppressed after 7 days of daily dosing; a backup method is advised during the first 48 hours. Combined pills provide full contraceptive protection within the first menstrual cycle if started within the first five days of bleeding.
Can I take desogestrel if I have a history of blood clots? No. A prior VTE episode is a contraindication for combined desogestrel/ethinylestradiol pills, and caution is advised even for the progestogen-only version. Discuss alternative non-hormonal methods with your clinician.
What should I do if I experience persistent breakthrough bleeding? Breakthrough bleeding is common during the initial months. If it continues beyond three cycles or is heavy, schedule a review to assess hormone levels, rule out uterine pathology, and consider switching to a different formulation.
Does taking desogestrel with food affect its absorption? Food does not significantly alter desogestrel bioavailability, so tablets may be taken with or without meals. Consistency in timing is more important for maintaining steady hormone levels.
Are there any foods or supplements I should avoid while using desogestrel? No specific dietary restrictions exist, but herbal supplements that induce CYP3A4 (e.g., St. John’s wort) may reduce effectiveness. Inform your healthcare provider of all over-the-counter products you use.
Can desogestrel be used to treat acne? Off-label, desogestrel has shown modest improvement in hormonal acne, especially when combined with estrogen. This use is not approved by the TGA, and a dermatologist should supervise treatment.
Is it safe to start desogestrel immediately after a miscarriage? Initiating a progestogen-only pill can be considered as soon as bleeding has ceased, but a clinician will evaluate uterine involution and overall health before recommending any hormonal method.
What information should I provide my doctor when discussing desogestrel?
- Complete medical history, including any clotting disorders or liver disease
- Full list of current medications, over-the-counter drugs, and supplements
- Details of menstrual patterns and any prior contraceptive experiences
- Specific concerns such as weight changes, mood symptoms, or acne

Disclaimer

The information provided about desogestrel is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing desogestrel for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing desogestrel.

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