Danazol Medications

Danazol is a synthetic hormone used to treat endometriosis by suppressing ovarian function. It also manages fibrocystic breast changes and bleeding disorders.

Danocrine

Danazol

$1.19 per pill

50 | 100 | 200mg

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About Danazol

Danazol is a synthetic androgenic steroid that is most commonly prescribed for the management of endometriosis-related pelvic pain and for the prevention of attacks in hereditary angioedema. Belonging to the class of 17-α-ethynylated androgen derivatives, it exerts its therapeutic effect by suppressing the pituitary-ovarian axis, thereby lowering circulating estrogen levels. The drug is marketed under several brand names, including Danatrol and Danocrine, while generic formulations are widely available. Although its primary approvals focus on gynecologic and immunologic conditions, clinicians sometimes employ Danazol off-label for symptomatic relief of fibrocystic breast disease. Its molecular action, clinical applications, and safety considerations make it a distinct option among hormonal therapies, especially for patients who have not responded to first-line treatments.

What is Danazol?

Danazol is classified as an androgenic and anabolic steroid. It was first approved by the U.S. Food and Drug Administration (FDA) in 1971 for the treatment of endometriosis, and later received European Medicines Agency (EMA) and Australian Therapeutic Goods Administration (TGA) endorsements for both endometriosis and hereditary angioedema. The drug binds to androgen receptors and exerts a negative feedback effect on the hypothalamic-pituitary-gonadal axis, leading to reduced secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). By lowering gonadotropin levels, endogenous estrogen production declines, which helps to regress ectopic endometrial tissue. Danazol is supplied both as branded tablets-most notably Danatrol-and as generic tablets, all of which can be purchased through our online pharmacy.

How Danazol Works

Mechanism of Action

Danazol interacts with multiple steroid hormone receptors. Its primary activity is agonism at the androgen receptor, which produces direct anti-estrogenic and anti-progesterone effects in target tissues. In addition, the drug inhibits enzymes involved in steroidogenesis, such as 17α-hydroxylase and aromatase, further decreasing estrogen synthesis. The combined receptor binding and enzyme inhibition reduce the proliferative stimulus on endometrial implants and stabilize the complement system in hereditary angioedema.

Therapeutic Effects

By dampening the estrogen surge, Danazol leads to the atrophy of ectopic endometrial glands, resulting in less pelvic pain and fewer dysmenorrheic episodes. In hereditary angioedema, the suppression of C1-esterase inhibitor degradation and modulation of bradykinin pathways diminish the frequency and severity of swelling attacks. The androgenic properties also contribute to a modest increase in high-density lipoprotein (HDL) cholesterol, though this effect is offset by other lipid alterations.

Onset and Duration

Clinical trials documented that pain relief in endometriosis patients becomes noticeable after 2-3 months of continuous therapy, with maximal benefit observed around the 6-month mark. For hereditary angioedema, prophylactic efficacy appears within 1 week of initiation and persists as long as the medication is maintained. Danazol’s half-life ranges from 3 to 10 hours, but steady-state hormonal suppression is achieved after several days of daily dosing.

Approved Uses and Applications

Approved Indications

Endometriosis-related pelvic pain: TGA-approved for women with surgically confirmed disease who have not responded adequately to non-steroidal anti-inflammatory drugs (NSAIDs) or hormonal contraceptives.
Hereditary angioedema (HAE) prophylaxis: Authorized for adult patients with type I or type II HAE to reduce the frequency of acute swelling episodes.

These approvals are supported by data from randomized controlled trials published in The New England Journal of Medicine and Lancet that demonstrated statistically significant reductions in pain scores and attack rates, respectively.

Off-Label Uses

Danazol has been employed off-label for symptomatic relief of fibrocystic breast disease and for certain cases of azoospermia where hormonal stimulation is desired. Such applications lack official endorsement from the TGA or FDA, and physicians prescribe them only after careful risk assessment.

Clinical Efficacy

In a multicenter trial of 234 women with endometriosis, Danazol 400 mg daily reduced visual analogue scale pain scores by 45 % compared with placebo (p < .001). For HAE, a 12-week study showed a 70 % decrease in attack frequency among patients receiving 200 mg twice daily versus baseline (p < .01). These outcomes illustrate Danazol’s potency when standard therapies are insufficient.

Buying Danazol from Our Online Pharmacy

Why Choose Our Service

Our pharmacy service bridges the gap for Australians who encounter limited local stock or high out-of-pocket costs. By leveraging international licensed partners, we ensure a reliable supply chain while maintaining strict quality controls.

Brand Names and Generic Options

Danatrol - the most recognized brand in the Australian market.
Danocrine - a formulation marketed in Europe but available through our platform.
Generic Danazol - the cost-effective alternative, offering the same active ingredient at up to 60 % lower price than branded tablets.

Quality & Safety

We work with suppliers that meet World Health Organization (WHO) Good Manufacturing Practice standards and are audited by the Australian Pharmacy Guild. Every batch undergoes stability testing and batch-release verification before shipment.

Pricing & Access

Through our online pharmacy, patients can secure generic Danazol for as little as AUD .25 per 200 mg tablet. Returning customers benefit from a lifetime 10 % discount on all reorders, making long-term therapy financially sustainable.

Discreet Delivery

Orders dispatched via our service arrive in unmarked packaging. Express shipping delivers within ≈ 7 days, whereas standard delivery reaches you in ≈ 3 weeks, both with tracking options to ensure privacy.

Dosing, Formulations & Administration

Available Formulations

Danazol is supplied as oral tablets in strengths of 100 mg, 200 mg, and 400 mg. No liquid or injectable forms are presently marketed for adult indications.

Typical Dosing Ranges

Endometriosis: Initial regimens often start at 200 mg once daily, with escalation to 400 mg daily based on symptom control and tolerability.
Hereditary Angioedema: Prophylactic protocols commonly employ 200 mg twice daily, adjusted after clinical evaluation.

These examples reflect standard practice; the exact dose must be individualized by a qualified health professional.

Administration Guidelines

Danazol tablets should be taken with food to lessen gastrointestinal irritation. Splitting doses (morning and evening) can improve hormone suppression consistency. Alcohol should be avoided, as it may exacerbate hepatic stress. Patients are advised to refrain from sharing medication and to store tablets at room temperature, away from moisture.

A clinician must determine the appropriate dose and regimen for each patient, taking into account medical history, concomitant drugs, and laboratory monitoring requirements.

Safety Profile & Considerations

Common Side Effects

Weight gain (≈ 15 % of users)
Nausea or abdominal discomfort (≈ 12 %)
Acne or oily skin (≈ 10 %)
Menstrual irregularities (≈ 9 %)

These events are generally mild to moderate and often improve with dose adjustment.

Serious Adverse Events

Hepatotoxicity: Elevations in transaminases have been reported in < 2 % of patients; severe liver injury is rare but warrants immediate withdrawal and hepatic work-up.
Lipid abnormalities: Decreases in HDL and increases in LDL may predispose to atherosclerosis; periodic lipid panels are recommended.
Virilization: Deepening of voice, hirsutism, and clitoromegaly can occur, especially at higher doses, and may be irreversible.

Contraindications

Pregnancy or lactation
Active or history of severe liver disease (e.g., cirrhosis)
Known hypersensitivity to Danazol or any excipients
Uncontrolled thromboembolic disorders

Drug Interactions

CYP3A4 inhibitors (ketoconazole, erythromycin) can raise Danazol plasma levels, increasing toxicity risk.
Warfarin - Danazol may potentiate anticoagulant effect, necessitating INR monitoring.
Other hormonal agents (combined oral contraceptives, testosterone) may amplify androgenic side effects.

Patients should provide a full medication list, including over-the-counter supplements, to their prescriber.

Special Populations

Pregnancy: Category X; teratogenic risk is high due to androgenic activity.
Breastfeeding: Contraindicated; drug is excreted in milk.
Elderly: Reduced hepatic clearance may require lower starting doses.
Renal or hepatic impairment: Dose reduction and close laboratory surveillance are advised.

Frequently Asked Questions

How does Danazol differ from GnRH agonists for endometriosis? Danazol suppresses estrogen via androgenic pathways, while GnRH agonists create a hypo-gonadotropic state by down-regulating pituitary GnRH receptors. Danazol is taken orally and often costs less, but it carries androgenic side effects that GnRH modulators avoid.
How long before Danazol produces noticeable pain relief in endometriosis? Most patients report a reduction in pelvic pain after 8-12 weeks of continuous therapy, with maximal improvement around 6 months.
What should I do if I experience severe abdominal pain while on Danazol? Severe abdominal pain may signal hepatic injury; stop the medication immediately and seek urgent medical evaluation, including liver function testing.
Does taking Danazol with food affect its absorption? Food modestly enhances oral bioavailability and reduces gastrointestinal upset, so the medication is recommended to be taken with meals.
Can Danazol be used to treat fibrocystic breast disease? Although some clinicians prescribe it off-label for symptomatic breast pain, official guidelines do not endorse this use, and alternative therapies are usually preferred.
What are the lipid changes associated with Danazol? The drug may lower HDL cholesterol and raise LDL levels; regular lipid profiling is advised, especially for patients with cardiovascular risk factors.
Is Danazol safe for long-term use? Chronic therapy increases the cumulative risk of liver dysfunction and lipid disturbances. Periodic monitoring and dose reassessment are essential for prolonged treatment.
Are there any foods I should avoid while taking Danazol? Limit high-fat meals that can exacerbate gastrointestinal side effects, and avoid excessive alcohol to protect liver health.
What monitoring is required while on Danazol? Baseline and periodic liver function tests, lipid panels, and complete blood counts are recommended. Hormonal assays may be useful for dose titration in endometriosis.
What information should I provide my doctor when discussing Danazol?
- Full list of current prescription and over-the-counter medications, including supplements.
- Detailed medical history focusing on liver disease, lipid disorders, and clotting abnormalities.
- Specific symptoms you hope to alleviate (e.g., pain severity, frequency of HAE attacks).
- Any prior hormonal therapies and their outcomes.

Disclaimer

The information provided about Danazol is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Danazol for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Danazol.