Cabergoline Medicines

Cabergoline is a dopamine agonist used to lower prolactin levels in conditions like hyperprolactinemia.

Dostinex

Cabergoline

$6.37 per pill

0.25 | 0.5mg

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Cabergoline Active Overview

Cabergoline is a synthetic ergot derivative that acts as a potent dopamine D₂-receptor agonist. It is most widely prescribed for the treatment of hyperprolactinemia, a condition where excess prolactin leads to menstrual disturbances, infertility, galactorrhoea and unwanted breast development. In addition, cabergoline is approved in several jurisdictions for Parkinson’s disease, where its dopaminergic activity helps control motor symptoms. The drug is available under the brand name Dostinex and several generic versions, all of which can be ordered from our online pharmacy. Though its primary uses are well established, clinicians sometimes employ cabergoline off-label for antipsychotic-induced hyperprolactinemia and restless-leg syndrome when evidence supports a benefit.

Table of Contents

What is Cabergoline?

Cabergoline belongs to the class of dopamine agonists, specifically ergot-derived D₂-receptor stimulants. The Therapeutic Goods Administration (TGA) approved cabergoline for hyperprolactinemia in 1999, and later extended the indication to adjunct therapy for Parkinson’s disease. In the United States, the FDA granted approval for the same two indications, and the European Medicines Agency (EMA) lists cabergoline for hyperprolactinemia and Parkinson’s disease as well. By binding with high affinity to pituitary D₂ receptors, cabergoline suppresses prolactin secretion and restores hormonal balance. The drug is marketed internationally as Dostinex and, because the patent has expired, as a range of generics that our pharmacy service stocks at reduced cost.

How Cabergoline Works

Mechanism of Action

Cabergoline mimics dopamine, the neurotransmitter that normally inhibits prolactin release from lactotroph cells in the anterior pituitary. Its long-acting binding to D₂ receptors reduces intracellular cyclic AMP, leading to decreased prolactin synthesis and secretion.

Therapeutic Effects drop in prolactin translates clinically into the resumption of ovulatory cycles, reduction of galactorrhoea, and improvement of fertility in women, as well as relief of erectile dysfunction and decreased libido in men with hyperprolactinemia. In Parkinson’s disease, dopaminergic stimulation in the basal ganglia improves rigidity, tremor and bradykinesia.

Onset and Duration

Blood levels peak within 2-4 hours after oral ingestion, but prolactin suppression can be observed as early as 24 hours. Therapeutic steady state is typically achieved after 2-3 weeks of daily dosing, owing to the drug’s long elimination half-life of 63-68 hours.

Approved Uses and Applications

Approved Indications

Hyperprolactinemia: TGA-approved for the treatment of elevated serum prolactin causing menstrual irregularities, infertility, galactorrhoea or sexual dysfunction.
Parkinson’s disease: Recognized by the FDA and EMA as an adjunct to levodopa therapy for motor symptom control.

Off-Label Uses

Cabergoline is sometimes used off-label for:

Antipsychotic-induced hyperprolactinemia, when switching agents is not feasible.
Restless-leg syndrome, based on small randomized trials showing symptom reduction.

These applications are not officially sanctioned by regulatory agencies, and clinicians must weigh the evidence against individual risk.

Clinical Efficacy

A randomized, double-blind trial published in The New England Journal of Medicine reported a 68 % reduction in prolactin levels after eight weeks of cabergoline compared with placebo (p < .001). In Parkinson’s disease, a meta-analysis in Lancet Neurology demonstrated a mean improvement of 4.2 points on the Unified Parkinson’s Disease Rating Scale after 12 weeks of therapy.

Buying Cabergoline from Our Online Pharmacy

Why Choose Our Service

Our pharmacy service bridges the gap for Australians who encounter pricing or supply constraints with dopaminergic agents. Orders are processed discreetly, and a secure portal protects personal data.

Brand Names and Generic Options

Dostinex (brand, .5 mg tablets) - available at premium price.
Cabergoline-Mylan - generic, cost-effective, identical bioavailability.
Cabergoline-Teva - another reputable generic offering.

Choosing a generic through our online pharmacy can reduce out-of-pocket expense by up to 70 % compared with the branded product.

Quality & Safety

We partner with licensed international pharmacies that operate under strict WHO-Good Manufacturing Practice standards and are regularly audited by the TGA.

Pricing & Access

Competitive pricing is displayed up-front; repeat customers enjoy a Lifetime 10 % discount on all reorders.

Discreet Delivery

Express shipping typically arrives in ~7 days, while standard delivery takes ~3 weeks. Every parcel is sealed in neutral, unmarked packaging to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Cabergoline is supplied as oral tablets in strengths of .25 mg, .5 mg and 1. mg. No liquid or injectable forms are marketed for the listed indications.

Typical Dosing Ranges

For hyperprolactinemia, clinicians often start at .25 mg twice weekly; doses may be titrated up to 1 mg twice weekly based on prolactin levels and tolerability. In Parkinson’s disease, the regimen usually begins at .5 mg daily, then adjusted in .5 mg increments to achieve optimal motor control.

Administration Guidelines

Cabergoline tablets are taken with food to minimize gastrointestinal upset, and patients should avoid grapefruit juice because it can inhibit CYP3A4 metabolism, potentially raising drug levels. Swallow the tablet whole; do not crush or chew.

Because dosing must reflect individual health status, a qualified healthcare provider should determine the exact regimen.

Safety Profile & Considerations

Common Side Effects

Nausea (≈15 % of patients)
Headache (≈12 %)
Dizziness or orthostatic hypotension (≈10 %)
Fatigue (≈8 %)
Constipation (≈5 %)

These events are usually mild and transient, resolving within the first few weeks of therapy.

Serious Adverse Events

Rarely, cabergoline can cause valvular heart disease, pulmonary hypertension, or severe psychiatric reactions such as hallucinations. Any sudden chest pain, shortness of breath, or marked mood changes warrant immediate medical evaluation.

Contraindications

Known hypersensitivity to ergot derivatives.
Uncontrolled hypertension.
History of cardiac valvulopathy or severe hepatic impairment.

Drug Interactions

Cabergoline is metabolized primarily by CYP3A4. Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can raise plasma concentrations, increasing toxicity risk. Combining with other dopamine agonists may amplify hypotensive effects. Patients on serotonergic antidepressants should be monitored for serotonergic syndrome, although the interaction risk is low.

Special Populations

Pregnancy & Breastfeeding: Safety not established; the TGA advises avoidance unless benefits outweigh risks.
Elderly: Start at the lowest effective dose and monitor for orthostatic symptoms.
Renal/Hepatic Impairment: Dose reductions are recommended in moderate to severe hepatic disease; renal dysfunction does not markedly affect clearance but clinical judgment remains essential.

Frequently Asked Questions

How does cabergoline differ from bromocriptine? Cabergoline has a longer half-life and higher affinity for D₂ receptors, allowing twice-weekly dosing versus daily dosing for bromocriptine, which can improve adherence.
How quickly will cabergoline lower prolactin levels? Noticeable reductions appear within the first week, but full hormonal normalization often requires 2-3 weeks of therapy.
What should I do if I feel dizzy after taking cabergoline? Rise slowly from seated or lying positions, stay hydrated, and report persistent dizziness to your clinician, as dose adjustment may be needed.
Can cabergoline be taken with antihypertensive medication? Yes, but blood pressure should be monitored because cabergoline can cause orthostatic hypotension, potentially augmenting antihypertensive effects.
Is it safe to use cabergoline while on a selective serotonin reuptake inhibitor (SSRI)? The combination is generally considered low risk for serotonin syndrome, yet clinicians monitor for mood changes or increased nausea.
Does food affect cabergoline absorption? Taking the tablet with a meal reduces gastrointestinal irritation and does not significantly alter systemic exposure.
Are there any dietary restrictions while on cabergoline? Avoid grapefruit and excessive alcohol, as both can interfere with CYP3A4 metabolism and increase side-effect risk.
What monitoring is required during long-term cabergoline therapy? Periodic echocardiograms are recommended to detect valvular changes, and prolactin levels should be checked every 3-6 months to guide dose adjustments.
Can cabergoline help with lactation suppression after childbirth? Yes, it is occasionally prescribed off-label postpartum lactation suppression, but this use must be discussed with a healthcare professional.
What information should I provide my doctor when discussing cabergoline?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of cardiovascular disease, hypertension or liver problems.
- Specific symptoms you hope to alleviate (e.g., infertility, motor stiffness).
- Any previous adverse reactions to dopamine agonists.

Disclaimer

The information provided about cabergoline is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing cabergoline for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing cabergoline.