Avanafil Medications

Avanafil is a fast-acting phosphodiesterase-5 (PDE5) inhibitor approved for the treatment of erectile dysfunction (ED) in adult men. By selectively blocking the PDE5 enzyme in penile tissue, it enhances the nitric-oxide-cGMP pathway, allowing smooth-muscle relaxation and increased blood flow needed for an erection. Commercially, it is best known under the brand name Stendra, but generic tablets are widely available. In Australia, the Therapeutic Goods Administration (TGA) approved avanafil for ED in 2013, building on its earlier U.S. FDA clearance in 2012. Beyond its primary indication, limited clinical investigations have explored off-label uses such as pulmonary arterial hypertension, though these applications remain unapproved. The drug’s rapid onset-often within 15 minutes-makes it a popular choice for men seeking spontaneity, while its safety profile aligns with other PDE5 inhibitors when used under medical supervision.

What is Avanafil?

Avanafil belongs to the class of selective phosphodiesterase-type 5 inhibitors, a group that includes sildenafil, tadalafil and vardenafil. The TGA granted marketing approval in 2013 for the treatment of erectile dysfunction, following the U.S. FDA’s 2012 approval based on pivotal Phase III trials. The drug works by inhibiting the PDE5 enzyme, which normally degrades cyclic guanosine monophosphate (cGMP). By preserving cGMP, avanafil promotes vasodilation in the corpus cavernosum, facilitating an erection when sexual stimulation occurs. It is marketed internationally as Stendra and is also sold under its generic name avanafil. Both branded and generic tablets can be purchased from our pharmacy with discreet packaging and competitive pricing.

How Avanafil Works

Mechanism of Action

Avanafil binds competitively to the active site of PDE5, preventing the breakdown of cGMP. The resulting accumulation of cGMP relaxes smooth-muscle cells in the penile arteries and corpus cavernosum, increasing inflow of oxygen-rich blood.

Therapeutic Effects

The biochemical cascade translates into a clinically useful erection that is both firm and sustainable, provided the patient experiences sexual arousal. Because avanafil’s inhibition is highly selective, fewer off-target effects on PDE6 (visual) and PDE1 (cardiac) are observed compared with earlier agents.

Onset and Duration

Clinical trials report an onset of action as early as 15 minutes, with peak plasma concentrations reached at about 30-45 minutes. The effective window typically lasts 4-6 hours, allowing flexibility for spontaneous activity.

Approved Uses and Applications

Approved Indications

• Erectile Dysfunction: Avanafil is indicated for the treatment of ED in adult males, as confirmed by the TGA and FDA.

Off-Label Uses

• Pulmonary Arterial Hypertension: Small pilot studies have evaluated avanafil’s vasodilatory effects on the pulmonary circuit, but the indication remains unapproved by regulatory agencies.

Clinical Efficacy

In a double-blind, placebo-controlled trial published in The New England Journal of Medicine, 73 % of men receiving avanafil reported successful intercourse, compared with 23 % on placebo. Similar response rates were observed across age groups, supporting its efficacy in both younger and older populations.

Buying Avanafil from Our Online Pharmacy

Why Choose Our Service

Our online pharmacy bridges the gap for Australians who encounter cost or availability barriers when seeking PDE5 inhibitors. By sourcing from licensed international distributors, we ensure authentic medication while protecting your privacy.

Brand Names and Generic Options

• Stendra (brand, 100 mg & 200 mg)
• Avanafil (generic, 100 mg & 200 mg)

Generic tablets typically cost 30-40 % less than the branded version, delivering the same clinical effect.

Quality & Safety

We partner with suppliers that meet WHO-mandated Good Manufacturing Practice (GMP) standards and operate under the oversight of national regulatory bodies.

Pricing & Access

Competitive pricing starts at AU$45 for a 30-tablet pack of generic avanafil, with a Lifetime 10 % discount on all reorders for registered customers.

Discreet Delivery

Orders ship via express (≈ 7 days) or standard (≈ 3 weeks) services, each packed in unmarked, tamper-evident envelopes to safeguard confidentiality.

Dosing, Formulations & Administration

Available Formulations

Avanafil is supplied as oral tablets in two strengths: 100 mg and 200 mg.

Typical Dosing Ranges

For most adults with erectile dysfunction, treatment is often initiated at 100 mg taken approximately 30 minutes before anticipated sexual activity. Depending on efficacy and tolerability, clinicians may increase the dose to 200 mg. No more than one dose should be taken per day.

Administration Guidelines

• Take with or without food; a high-fat meal may modestly delay absorption but does not diminish overall effectiveness.
• Avoid concomitant use of nitrate medications, as the combination can precipitate severe hypotension.

A qualified healthcare provider must tailor the exact regimen to individual health status, comorbidities, and concomitant drugs.

Safety Profile & Considerations

Common Side Effects

• Headache (≈ 12 % of users)
• Flushing (≈ 9 %)
• Nasal congestion (≈ 8 %)
• Back pain (≈ 6 %)
• Dyspepsia (≈ 5 %)

These events are usually mild and transient.

Serious Adverse Events

• Priapism (prolonged erection > 4 hours) - requires immediate medical attention.
• Vision disturbances such as sudden loss of vision, though rare (< .1 %).
• Cardiovascular events including myocardial infarction or stroke in patients with pre-existing heart disease.

Contraindications

• Concurrent nitrate therapy (e.g., nitroglycerin)
• Severe uncontrolled hypertension or hypotension
• History of non-arteritic anterior ischemic optic neuropathy (NAION)

Drug Interactions

• CYP3A4 inhibitors (ketoconazole, erythromycin) may increase avanafil plasma levels, warranting dose adjustment.
• Other PDE5 inhibitors - concurrent use amplifies the risk of hypotension.
• Alpha-blockers (tamsulosin) - monitor blood pressure closely.

Special Populations

• Pregnancy & Breastfeeding: Not recommended; safety data are lacking.
• Older Adults: Initiate at lower dose (100 mg) due to potential cardiovascular comorbidities.
• Hepatic/Renal Impairment: Mild to moderate impairment does not require dose change, but severe disease should be evaluated by a clinician.

Frequently Asked Questions

• How does avanafil differ from sildenafil? Avanafil has a faster onset (15 minutes vs. 30-60 minutes for sildenafil) and a more selective PDE5 inhibition profile, which may reduce visual side effects.

• How long before avanafil produces noticeable effects for erectile dysfunction? Most men report an erection within 15-30 minutes after ingestion, especially when taken on an empty stomach.

• What should I do if I experience a headache after taking avanafil? Over-the-counter analgesics such as acetaminophen are generally safe, but consult a healthcare professional if headaches persist or become severe.

• Can avanafil be taken with food? Yes. A high-fat meal may modestly delay absorption, but the overall efficacy remains unchanged.

• Is it safe to use avanafil if I have high blood pressure? Avanafil is contraindicated only in severe uncontrolled hypertension; stable hypertension under treatment is acceptable after physician assessment.

• What are the signs of priapism and how should I respond? A painful erection lasting longer than 4 hours warrants immediate emergency care to prevent permanent tissue damage.

• Are there any medications that must never be combined with avanafil? Nitrate drugs (e.g., nitroglycerin) are absolutely prohibited due to the risk of life-threatening hypotension.

• Does alcohol affect the performance of avanafil? Moderate alcohol intake may reduce erectile response; excessive consumption can increase the likelihood of side effects like dizziness.

• What information should I provide my doctor when discussing avanafil?

  • Complete list of current medications, including over-the-counter drugs and supplements.
  • History of cardiovascular disease, blood pressure, and any prior episodes of priapism.
  • Existing liver or kidney conditions.
  • Personal goals for sexual health and any concerns about side effects.

Disclaimer

The information provided about avanafil is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing avanafil for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing avanafil.

External Resources about Avanafil

• Avanafil | healthdirect
• Avanafil - Austra Health
• Avanafil (oral route) - Side effects & dosage - Mayo Clinic
• Avanafil (Stendra): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
• Avanafil - Memorial Sloan Kettering Cancer Center
• Spedra - Patient leaflet, side effects, dosage | Patient info
• Avanafil Uses, Side Effects & Warnings - en