Alfuzosin Medications

Alfuzosin is an alpha-blocker medication used to relieve urinary symptoms caused by an enlarged prostate in men.

Uroxatral

Alfuzosin

$1.44 per pill

10mg

Select pack

About Alfuzosin

Alfuzosin is a selective α₁-adrenergic receptor antagonist primarily prescribed to alleviate the lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH). Belonging to the class of α-blockers, it relaxes smooth muscle in the prostate and bladder neck, improving urine flow and reducing urgency or nocturia. The medication is widely marketed under the generic name Alfuzosin and the brand name Uroxatral in some markets. Since its approval by the Therapeutic Goods Administration (TGA) in 2001, it has become a cornerstone of medical therapy for men with BPH who seek symptom relief without surgical intervention. Off-label, clinicians occasionally explore its use for other smooth-muscle-related conditions, though such applications lack formal endorsement. Understanding how Alfuzosin works, its dosing options, and its safety profile empowers patients to make informed choices when buying Alfuzosin online or discussing treatment with their healthcare provider.

What is Alfuzosin?

Alfuzosin is an α₁-adrenergic blocker classified as a uroselective agent because it preferentially targets the α₁A receptors of the prostate and bladder neck. The TGA approved the drug in 2001 for the treatment of BPH, and later the FDA and EMA confirmed the same indication, expanding its availability worldwide. Its core molecular action involves competitive inhibition of α₁-adrenoceptors, which blocks norepinephrine-induced contraction of prostatic smooth muscle. By reducing this tone, Alfuzosin lowers urethral resistance and eases the passage of urine. The product is sold as 10 mg tablets, both as a branded preparation (Uroxatral) and as a generic formulation that can be purchased from our online pharmacy.

How Alfuzosin Works

Mechanism of Action

Alfuzosin binds reversibly to α₁A-adrenergic receptors on prostatic stromal cells and the bladder neck. This antagonism prevents catecholamine-mediated calcium influx, leading to smooth-muscle relaxation. Because the drug exhibits uroselectivity, vascular α₁B receptors are largely spared, minimizing systemic blood-pressure effects.

Therapeutic Effects

The relaxation of prostatic and bladder-neck smooth muscle translates into decreased urinary resistance, improved maximum flow rate (Qmax), and a reduction in symptoms such as hesitancy, weak stream, and nocturnal urgency. Clinical trials have shown a 25-30 % improvement in International Prostate Symptom Score (IPSS) after several weeks of therapy.

Onset and Duration

Patients typically notice symptom improvement within 2 weeks, though maximal benefit may require up to 8 weeks of continuous dosing. The half-life of alfuzosin is approximately 8 hours, and steady-state concentrations are achieved after 3-4 days of once-daily administration.

Approved Uses and Applications

Approved Indications

Benign prostatic hyperplasia (BPH): Relief of lower urinary tract symptoms in adult males, as endorsed by the TGA, FDA, and EMA.
Adjunctive therapy for ureteric colic: Occasionally used off-label to relax ureteral smooth muscle, though evidence remains limited.

Off-Label Uses

Alfuzosin has been investigated for neurogenic bladder dysfunction and for facilitating the passage of ureteral stones, but these indications are not formally approved by regulatory agencies. Clinicians may prescribe it off-label when conventional therapies are unsuitable, provided they discuss the experimental nature with the patient.

Clinical Efficacy

In a pivotal double-blind, placebo-controlled trial published in The New England Journal of Medicine, 112 men receiving 10 mg alfuzosin daily experienced a mean IPSS reduction of 5.5 points versus 2.1 points with placebo (p < .001). Similar outcomes were reported in the Lancet meta-analysis of six BPH trials, confirming a consistent improvement in urinary flow rates and quality-of-life scores.

Buying Alfuzosin from Our Online Pharmacy

Why Choose Our Service

Our pharmacy service bridges the gap for Australians who encounter limited stock or high prices at local pharmacies. By sourcing directly from licensed international distributors, we ensure a steady supply of high-quality alfuzosin tablets.

Brand Names and Generic Options

Uroxatral (brand, 10 mg) - often priced higher but widely recognized.
Alfuzosin (generic, 10 mg) - offers a cost-effective alternative with identical bioavailability.

Through our platform you can compare prices instantly and select the option that best fits your budget.

Quality & Safety

We partner exclusively with pharmacies that operate under WHO Good Manufacturing Practice (GMP) standards and hold valid TGA import licences. All products undergo rigorous verification before shipment.

Pricing & Access

Generic alfuzosin typically costs 30-40 % less than the branded version. In addition, a Lifetime 10 % discount applies to all reorders, making long-term management more affordable.

Discreet Delivery

Orders are packaged in plain, tamper-evident envelopes. Express shipping delivers within ~7 days, while standard delivery arrives in ~3 weeks, ensuring privacy and convenience.

Dosing, Formulations & Administration

Available Formulations

Alfuzosin is supplied as oral tablets in a single strength of 10 mg. No extended-release or liquid forms are currently marketed in Australia.

Typical Dosing Ranges

For adults with BPH, treatment is often initiated at 10 mg once daily, taken after the same meal each day to maintain consistent plasma levels. Clinicians may adjust the dose based on therapeutic response and tolerability, but the 10 mg regimen remains the standard.

Administration Guidelines

Food: Taking the tablet with a meal helps reduce peak-to-trough fluctuations; however, the drug can be taken with or without food if the patient prefers a consistent routine.
Timing: Administer the dose at the same time each day to avoid variability in symptom control.
Interaction precautions: Avoid concurrent use of strong CYP3A4 inhibitors (e.g., ketoconazole) without medical supervision.

A qualified healthcare professional must determine the exact dose and formulation based on individual factors such as hepatic function and concomitant medications.

Safety Profile & Considerations

Common Side Effects

Dizziness (≈12 % of patients)
Headache (≈10 %)
Fatigue or asthenia (≈8 %)
Nasal congestion (≈6 %)
Orthostatic hypotension (≈4 %)

These events are typically mild and resolve spontaneously or after dose adjustment.

Serious Adverse Events

Severe hypotension or syncope requiring medical attention
Priapism (rare but urological emergency)
Intra-operative floppy iris syndrome during cataract surgery

Any sudden onset of these symptoms warrants immediate evaluation.

Contraindications

Severe hepatic impairment (Child-Pugh class C)
Known hypersensitivity to alfuzosin or any formulation component
Concurrent use of potent CYP3A4 inhibitors without dose modification

Drug Interactions

CYP3A4 inhibitors: Ketoconazole, erythromycin, clarithromycin - may increase alfuzosin plasma concentrations, raising the risk of hypotension.
Other α-blockers: Co-administration with tamsulosin or doxazosin can cause additive blood-pressure lowering effects.
Antihypertensives: May enhance the hypotensive response; clinicians often monitor blood pressure closely.

Special Populations

Elderly: Age-related declines in hepatic metabolism may necessitate careful monitoring for dizziness or falls.
Pregnancy & Lactation: No adequate human data; the drug is generally avoided.
Renal impairment: No dose adjustment required for mild to moderate renal dysfunction, but caution is advised in severe cases.

Frequently Asked Questions

How does Alfuzosin differ from Tamsulosin? Alfuzosin exhibits broader α₁-receptor blockade with less selectivity for the α₁A subtype than tamsulosin, potentially resulting in a slightly higher incidence of orthostatic hypotension but comparable efficacy for BPH symptoms.
How long before Alfuzosin produces noticeable effects for BPH? Most patients report symptom improvement within 2 weeks, while full therapeutic benefit may take up to 8 weeks of continuous therapy.
What should I do if I experience dizziness after taking Alfuzosin? Rise slowly from sitting or lying positions, stay hydrated, and avoid driving or operating heavy machinery until the sensation resolves. If dizziness persists or is severe, contact your healthcare provider.
Does taking Alfuzosin with food affect its absorption? Food can modestly increase the drug’s bioavailability, providing a smoother plasma concentration curve. Consistency is key-take the medication with the same type of meal each day.
Can I use Alfuzosin if I am on a statin? No direct pharmacokinetic interaction has been identified, but both agents can cause muscle-related side effects. Inform your clinician of all concurrent medications.
Is Alfuzosin safe for men with hypertension? The drug may lower blood pressure modestly; patients with well-controlled hypertension usually tolerate it, but blood-pressure monitoring is advisable, especially during the initiation phase.
Are there any foods I should avoid while taking Alfuzosin? Grapefruit juice inhibits CYP3A4 and can raise alfuzosin levels, potentially increasing hypotensive risk. It is best to limit or avoid grapefruit products.
What information should I provide my doctor when discussing Alfuzosin?
- Complete list of current prescription and over-the-counter medications, including supplements
- History of cardiovascular disease, liver dysfunction, or low blood pressure episodes
- Specific urinary symptoms, their severity, and any prior BPH treatments

Disclaimer

The information provided about Alfuzosin is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Alfuzosin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Alfuzosin.